Results 81 to 90 of about 9,869 (220)
MicrobiologyOpen, Volume 14, Issue 5, October 2025.Antimicrobial resistance (AMR) poses a critical threat to global health, affecting humans, animals, and the environment. This review explores major drivers and hotspots of AMR and outlines innovative strategies, including One Health–based interventions, to mitigate the spread of resistant pathogens and address this escalating worldwide health challenge.
Kindu Alem +4 more
wiley +1 more source
Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
American Journal of Human Biology, Volume 37, Issue 9, September 2025.ABSTRACT Inflammation is the immune system's natural response to initial tuberculosis infection. Tuberculosis bacteria have gained adaptations to manipulate the inflammatory process, sometimes settling into latency and containment in granulomas, ensuring their survival.
Stacie Burke
wiley +1 more source
Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin
Toxins, 2010 Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax,
Jennifer Bromberg-White +2 more
doaj +1 more source
Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.The interaction between inflammasomes and autophagy is crucial for maintaining the balance between necessary immune responses and the avoidance of excessive inflammation. Autophagy can inhibit the activation of the NLRP3 inflammasome by degrading endogenous activators, such as damaged mitochondria that produce reactive oxygen species (ROS), as well as ...
Sai Liu, Jingzhou Zhang
wiley +1 more source
Positive Microbiology in the Movies
Microbial Biotechnology, Volume 18, Issue 9, September 2025.How ‘Positive Microbiology’ is portrayed in commercial movies and its potential as a tool for education and engaging general audiences to counteract germaphobia. Image done with freepik. ABSTRACT Microbes are essential for sustaining life in our planet.
Manuel Sánchez‐Angulo
wiley +1 more source
A Frailty‐Based Plasma Proteomic Signature Capturing Overall Health and Well‐Being in Older Adults
Aging Cell, Volume 24, Issue 9, September 2025.We derived a 25‐protein blood‐based frailty signature (proteomic frailty index, pFI) predictive of the cumulative frailty index. The pFI was validated across independent cohorts and was significantly associated with physical, clinical, and cognitive function, as well as incident mortality and dementia, highlighting its potential as a biomarker of ...
Sanish Sathyan +13 more
wiley +1 more source
Anthrax: Transmission, Pathogenesis, Prevention and Treatment
ToxinsBacillus anthracis is a deadly pathogen that under unfavourable conditions forms highly resistant spores which enable them to survive for a long period of time. Spores of B.
Nitika Sangwan +7 more
doaj +1 more source
A Human/Murine Chimeric Fab Antibody Neutralizes Anthrax Lethal Toxin In Vitro
Clinical and Developmental Immunology, 2013 Human anthrax infection caused by exposure to Bacillus anthracis cannot always be treated by antibiotics. This is mostly because of the effect of the remaining anthrax toxin in the body.
Guipeng Ding +5 more
doaj +1 more source
Anthrax Toxins—Roadblocks for Exocytic Trafficking [PDF]
Developmental Cell, 2010 Anthrax toxins cause vascular dysfunction, in part by perturbing the endothelial cell barrier. Reporting in Nature, Guichard et al. shed new light on the mechanism by which this occurs and show that anthrax toxins interfere with exocytic delivery of cadherins to endothelial cell junctions by antagonizing the exocyst complex.
openaire +2 more sources