Results 51 to 60 of about 131,343 (218)

Immunopathogenesis of rheumatoid arthritis [PDF]

, 2017
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that
Ahmed, Ai, Ai, Anzilotti, Arend, Astorri, Benham, Bombardieri, Bottini, Bottini, Byng-Maddick, Catrina, Catrina, Charles-Schoeman, Christophorou, Corsiero, Croft, de Aquino, de Hair, Deane, Dennis, Diarra, Ekwall, El-Gabalawy, Ferreira, Filer, Firestein, Firestein, Firestein, Firestein, Firestein, Fonseca, Franz, Gary S. Firestein, Genovese, Hammaker, Harre, Hill, Horiuchi, Huber, Iain B. McInnes, Joosten, Juarez, Kaminsky, Karouzakis, Kelly, Kiener, Kim, Kinslow, Kirschmann, Klarenbeek, Konig, Konig, Krishnadas, Krishnamurthy, Källberg, Langley, Law, Lee, Lefèvre, Linn-Rasker, Liu, Lubberts, Lundström, Makrygiannakis, Matsumoto, McInnes, McInnes, McInnes, McInnes, McKellar, Miossec, Mydel, Müller-Ladner, Nakamachi, Nakano, Nakano, Nam, Okada, Pap, Perlman, Pitzalis, Randen, Rawlings, Raychaudhuri, Raza, Reynisdottir, Reynisdottir, Robertson, Rodríguez-Carrio, Rombouts, Rossetti, Scally, Scher, Schiff, Shi, Shi, Smolen, Smolen, Snir, Sokolove, Stanczyk, Suzuki, Tan, Tran, Tsaprouni, van Beers, van der Helm-van Mil, Vassallo, Wang, Wegner, Weyand, Yamamoto, Yang, Zhang, Zvaifler   +115 more
core   +1 more source

Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy

BMC Musculoskeletal Disorders, 2021
Background Blocking of the Tumor Necrosis Factor (TNF) activity is a successful therapeutic approach for 50–60% of rheumatoid arthritis (RA) patients. However, there are yet no biomarkers to stratify patients for anti-TNF therapy.
Antonio Julià, María López-Lasanta, Francisco Blanco, Antonio Gómez, Isabel Haro, Antonio Juan Mas, Alba Erra, Ma Luz García Vivar, Jordi Monfort, Simón Sánchez-Fernández, Isidoro González, Mercedes Alperi, Raúl Castellanos-Moreira, Antonio Fernández-Nebro, César Díaz-Torné, Núria Palau, Raquel Lastra, Jordi Lladós, Raimon Sanmartí, Sara Marsal   +19 more
doaj   +1 more source

Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti-citrullinated protein antibodies per se:a multicenter cohort study [PDF]

, 2016
BACKGROUND: The contribution of smoking to rheumatoid arthritis (RA) is hypothesized to be mediated through formation of anti-citrullinated protein antibodies (ACPA).
Ajeganova, Sofia, Division of Musculoskeletal & Dermatological Sciences (L5), Hafström, Ingiäld, Huizinga, Tom W J, Humphreys, Jennifer, Karolinska Institutet, Karolinska University Hospital, Kyoto University, Leiden University, Leiden University Medical Center, Lund University, MacGregor, Alex J, Matsuda, Fumihiko, Mimori, Tsuneyo, Muhammad, Ammar, Svensson, Björn, Symmons, Deborah, Terao, Chikashi, Toes, René E M, Trouw, Leendert A, University of East Anglia, van der Helm-van Mil, Annette H M, Van Der Woude, Diane, van Wesemael, Tineke J, Verstappen, Suzanne   +24 more
core   +1 more source

Anti-carbamylated protein antibodies are associated with early abatacept response in rheumatoid arthritis. Comment on: Anti-carbamylated protein antibodies as a clinical response predictor in rheumatoid arthritis patients treated with abatacept

Clinical and Experimental Rheumatology, 2021
Peer ...
Castellanos-Moreira, R., Gómez, A., Haro Villar, Isabel, Ruiz-Esquide, V., Marsal, V., Sanmartí, Raimon   +5 more
openaire   +3 more sources

Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritis [PDF]

Xin yixue, 2022
Objective To probe into the level and clinical significance of anti-carbamylated protein （CarP） antibody in serologically negative patients with rheumatoid arthritis （RA）.
Wu Tao, Chen Chutao, Yang Lijuan, Zou Yaowei, Ma Jianda, Xu Yanhui, Jia Lei, Dai Lie
doaj   +1 more source

Mucosa-Environment Interactions in the Pathogenesis of Rheumatoid Arthritis [PDF]

, 2019
Mucosal surfaces play a central role in the pathogenesis of rheumatoid arthritis (RA). Several risk factors, such as cigarette smoking, environmental pollution, and periodontitis interact with the host at the mucosal level, triggering immune system ...
Conti, Fabrizio, Di Franco, Manuela, Guzzo, Maria Paola, Iannuccelli, Cristina, Lucchino, Bruno, Spinelli, Francesca Romani   +5 more
core   +1 more source

Meta-Analysis: Diagnostic Accuracy of Anti-Carbamylated Protein Antibody for Rheumatoid Arthritis

PLOS ONE, 2016
The anti-carbamylated protein (CarP) antibody is a novel biomarker that might help in the diagnosis of rheumatoid arthritis (RA). We aim to assess the diagnostic value of anti-CarP antibody for RA.We systematically searched PubMed, Embase, the Cochrane Library, Web of Science, and Scopus for studies published by December 15, 2015.
Li, Liubing, Deng, Chuiwen, Chen, Si, Zhang, Shulan, Wu, Ziyan, Hu, Chaojun, Zhang, Fengchun, Li, Yongzhe   +7 more
openaire   +5 more sources

Autoantibodies in inflammatory arthritis [PDF]

, 2016
Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterized by extensive synovitis resulting in erosions of articular cartilage and marginal bone with joint destruction.
Chimenti, Ms, Conigliaro, P, Novelli, L, Perricone, C, Perricone, R, Sunzini, F, Triggianese, P   +6 more
core   +1 more source

Anti-carbamylated Protein Antibody Levels Correlate with Anti-Sa (Citrullinated Vimentin) Antibody Levels in Rheumatoid Arthritis [PDF]

The Journal of Rheumatology, 2015
Objective.The presence of anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) indicates a breach in immune tolerance. Recent studies indicate that this breach extends to homocitrullination of lysines with the formation of anti-carbamylated protein (anti-CarP) antibodies.
Gregory J, Challener, Jonathan D, Jones, Adam J, Pelzek, B JoNell, Hamilton, Gilles, Boire, Artur José, de Brum-Fernandes, Ariel, Masetto, Nathalie, Carrier, Henri A, Ménard, Gregg J, Silverman, William F C, Rigby   +10 more
openaire   +2 more sources

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers : implications for autoimmunity in rheumatoid arthritis [PDF]

, 2015
Introduction: Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic.
Bracke, Ken, Brusselle, Guy, Correia, Raquel ESM, Fischer, Roman, Kessler, Benedikt M, Lugli, Elena B, Lundberg, Karin, Montgomery, Anna B, Venables, Patrick J   +8 more
core   +2 more sources