Results 1 to 10 of about 25,158 (228)

Specificity of Anti-Citrullinated Protein Antibodies to Citrullinated α-Enolase Peptides as a Function of Epitope Structure and Composition [PDF]

Antibodies, 2021
Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1–2% of the world population. In addition to the first discovered serologic markers for RA, the rheumatoid factors (RFs), anti-citrullinated protein antibodies (ACPAs) are even ...
Ilaria Fanelli, Paolo Rovero, Paul Robert Hansen, Jette Frederiksen, Gunnar Houen, Nicole Hartwig Trier   +5 more
doaj   +2 more sources

Specificity of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis [PDF]

Antibodies, 2019
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. The majority of individuals with RA are positive for the disease-specific anti-citrullinated protein antibodies (ACPAs).
Nicole H. Trier, Bettina E. Holm, Paul R. Hansen, Ole Slot, Henning Locht, Gunnar Houen   +5 more
doaj   +2 more sources

Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing In Vivo Epitopes of Its γ Chain One of Which Is Not Cross Reactive With Anti-Citrullinated Protein Antibodies [PDF]

Frontiers in Immunology, 2021
To identify the targets recognized by anti-carbamylated protein antibodies (anti-CarP) in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and to evaluate ...
Pauline Brevet, Pauline Brevet, Claire Lattard, Claire Lattard, Clément Guillou, Pascal Rottenberg, Patrice Fardellone, Xavier Le-Loët, Thierry Lequerré, Thierry Lequerré, Pascal Cosette, Olivier Boyer, Olivier Boyer, Manuel Fréret, Manuel Fréret, Olivier Vittecoq, Olivier Vittecoq   +16 more
doaj   +2 more sources

Epitope Specificity of Anti-Citrullinated Protein Antibodies [PDF]

Antibodies, 2017
Anti-citrullinated protein antibodies are primarily associated with a progressive course in the autoimmune disease rheumatoid arthritis, a disease with a chronic and inflammatory nature.
Nicole H. Trier, Gunnar Houen
doaj   +2 more sources

Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3. [PDF]

PLoS ONE, 2018
OBJECTIVE:Peptidylarginine deiminase 2 (PAD2) and PAD4 are expressed in the synovium of rheumatoid arthritis (RA) patients and catalyze citrullination of arginine residues in proteins targeted by anti-citrullinated protein antibodies (ACPAs).
Dres Damgaard, Mandar Bawadekar, Ladislav Senolt, Allan Stensballe, Miriam A Shelef, Claus H Nielsen   +5 more
doaj   +2 more sources

Rheumatoid arthritis and the proinflammatory cytokine IL-17 [PDF]

Folia Medica, 2023
Introduction: Rheumatoid arthritis (RA) is the most common inflammatory joint disease. Various proinflammatory cytokines are involved in the pathogenesis of this chronic disorder.
Pavel Selimov, Rositsa Karalilova, Ljubinka Damjanovska, Ginka Delcheva, Teodora Stankova, Katya Stefanova, Ana Maneva, Teodor Selimov, Anastas Batalov   +8 more
doaj   +3 more sources

Identification of lipopolysaccharide‐binding protein as a novel citrullinated autoantigen in rheumatoid arthritis

Rheumatology & Autoimmunity, 2022
Background A specific feature of the autoimmune response in rheumatoid arthritis (RA) is the presence of anti‐citrullinated protein antibodies (ACPAs) in patient sera. These antibodies can appear several years before disease onset and are involved in the
Xiaozhen Zhao, Yuling Chen, Wen Wen, Yongjing Cheng, Ru Li, Xu Liu, Yuhui Li, Rulin Jia, Haiteng Deng, Zhanguo Li, Xiaolin Sun   +10 more
doaj   +1 more source

Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology

Frontiers in Immunology, 2022
Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated ...
Natalia Sherina, Charlotte de Vries, Nastya Kharlamova, Natalie Sippl, Xia Jiang, Boel Brynedal, Elin Kindstedt, Elin Kindstedt, Monika Hansson, Linda Mathsson-Alm, Linda Mathsson-Alm, Lena Israelsson, Ragnhild Stålesen, Saedis Saevarsdottir, Saedis Saevarsdottir, Rikard Holmdahl, Aase Hensvold, Aase Hensvold, Gunnar Johannsen, Gunnar Johannsen, Kaja Eriksson, Kaja Eriksson, Federica Sallusto, Federica Sallusto, Anca I. Catrina, Anca I. Catrina, Johan Rönnelid, Caroline Grönwall, Tülay Yucel-Lindberg, Tülay Yucel-Lindberg, Lars Alfredsson, Lars Alfredsson, Lars Klareskog, Luca Piccoli, Vivianne Malmström, Khaled Amara, Karin Lundberg   +36 more
doaj   +1 more source

Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis. [PDF]

PLoS ONE, 2016
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting the joints. Anti-citrullinated protein antibodies (ACPA) are frequently found in RA.
Adrienn Markovics, Tímea Ocskó, Robert S Katz, Edit I Buzás, Tibor T Glant, Katalin Mikecz   +5 more
doaj   +1 more source

In Rheumatoid Arthritis Patients, HLA-DRB1*04:01 and Rheumatoid Nodules Are Associated With ACPA to a Particular Fibrin Epitope

Frontiers in Immunology, 2021
ObjectivesRheumatoid arthritis (RA) is associated with HLA-DRB1 genes encoding the shared epitope (SE), a 5-amino acid motive. RA is usually preceded by the emergence of anti-citrullinated protein/peptide antibodies (ACPAs). Citrulline is a neutral amino
Guillaume Larid, Mikael Pancarte, Géraldine Offer, Cyril Clavel, Marielle Martin, Vincent Pradel, Isabelle Auger, Pierre Lafforgue, Jean Roudier, Jean Roudier, Guy Serre, Nathalie Balandraud, Nathalie Balandraud   +12 more
doaj   +1 more source