Results 81 to 90 of about 5,314,909 (200)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

C-reactive protein is essential for innate resistance to pneumococcal infection. [PDF]

, 2014
No deficiency of human C-reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not known.
Lawrence, Rachel A., Read, Kevin D., Aviva Petrie, Pepys, M B, Pepys, MB, Hutchinson, Winston L., LSHTM, Read, Kevin D, Raynes, JG, Read, KD, J. Brian Souza, Tennent, G A, Stephan Ellmerich, Loeffler, JM, Simons, JP, Rachel A. Lawrence, Simons, J Paul, Tennent, GA, John G. Raynes, Dundee, Glenys A. Tennent, Ellmerich, Stephan, Ellmerich, S, Tennent, Glenys A, Al-Shawi, Raya, Petrie, A, Tennent, Glenys A., Simons, J. Paul, Lawrence, R A, Jutta M. Loeffler, Lawrence, RA, Hutchinson, Winston L, J. Paul Simons, de Souza, J Brian, de Souza, J. Brian, Kevin D. Read, Raynes, John G., Raynes, J G, Read, K D, Mark B. Pepys, Hutchinson, WL, de Souza, JB, Loeffler, Jutta M, Petrie, Aviva, Al-Shawi, R, Pepys, Mark B., Lawrence, Rachel A, Raynes, John G, Loeffler, J M, de Souza, J B, Hutchinson, W L, Pepys, Mark B, Raya Al‐Shawi, Winston L. Hutchinson, Loeffler, Jutta M., Simons, J P, UCL   +56 more
core   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu, Tsu‐Hsiang Lu, Yi‐Chan Wu, Chia‐Wei Lin, Chia‐Wen Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source

Factors related to seroconversion of anti-cyclic citrullinated peptide antibody after the onset of rheumatoid arthritis: a case-control study and systematic review

Immunological Medicine
Anti-cyclic citrullinated peptide (CCP) antibodies typically present before rheumatoid arthritis (RA) but appear (seroconvert) after disease onset in some patients. This study analyzed factors related to anti-CCP seroconversion.
Yui Kosumi, Ryoko Asano, Aki Sugano, Masaru Yoshimura, Ryo Hisada, Michihito Kono, Yuichiro Fujieda, Tatsuya Atsumi, Masaru Kato   +8 more
doaj   +1 more source

Pre-treatment antinuclear antibody positivity, therapeutic efficacy and persistence of biologics in rheumatoid arthritis

Romanian Journal of Laboratory Medicine, 2016
Introduction: Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) are poor prognostic factors in rheumatoid arthritis (RA). The therapeutic implication of antinuclear antibody (ANA) positivity in RA is still debated. The study aims to
Codreanu Cătălin, Mogoșan Corina, Popescu Claudiu Costinel, Rednic Simona, Popovici Horațiu, Pârvu Magda, Opriș Daniela, Ionescu Ruxandra   +7 more
doaj   +1 more source

Increased peptidylarginine deiminases expression during the macrophage differentiation and participated inflammatory responses

Arthritis Research & Therapy, 2019
Objective To investigate the expression of peptidylarginine deiminases (PADIs) during macrophage differentiation and its role in inflammatory responses.
Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang, Ming-Chi Lu   +5 more
doaj   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Antibodies to carbamylated alpha-enolase epitopes in rheumatoid arthritis also bind citrullinated epitopes and are largely indistinct from anti-citrullinated protein antibodies

, 2016
Background: In addition to anti-citrullinated protein antibodies (ACPAs), antibodies targeting carbamylated (i.e., homocitrullinated) proteins (anti-CarP antibodies) have been described in rheumatoid arthritis (RA). However, the extent to which anti-CarP
Evan Reed, Lars Alfredsson, Jiang, Xia,, Kharlamova, Nastya,, Kharlamova, Nastya, Jiang, Xia, Anca I. Catrina, Rönnelid, Johan, Ytterberg, Jimmy, Rönnelid, Johan,, Catrina, Anca I., Xia Jiang, Ytterberg, A. Jimmy, Linda Mathsson-Alm, Johan Rönnelid, Monika Hansson, Reed, Evan, Israelsson, Lena,, Mathsson-Alm, Linda, Catrina, Anca I.,, Reed, Evan,, Ytterberg, A. Jimmy,, Karin Lundberg, Alfredsson, Lars,, Lundberg, Karin, Mathsson Alm, Linda, Israelsson, Lena, Mathsson-Alm, Linda,, Hansson, Monika,, Alfredsson, Lars, Lena Israelsson, Lundberg, Karin,, A. Jimmy Ytterberg, Hansson, Monika, Nastya Kharlamova   +34 more
core   +1 more source