Results 101 to 110 of about 5,314,909 (200)

Antibodies to a new viral citrullinated peptide, VCP2: fine specificity and relation with anti-CCP and anti-VCP1 [PDF]

, 2011
Summary: Anti-citrullinated protein/peptide antibodies (ACPA) are a hallmark of rheumatoid arthritis (RA) and can be measured using different citrullinated substrates.
MIGLIORINI, PAOLA, I Puxeddu, Di Colo G, F Pratesi, C Tommasi, PRATESI, FEDERICO, G Di Colo, Migliorini P., Pratesi F, Sardano E, Anzilotti C, P Migliorini, Tommasi C, PUXEDDU, ILARIA, C Anzilotti, E Sardano   +15 more
core   +1 more source

Factor reumatoideo, anticuerpos antipéptidos citrulinados y actividad de la enfermedad en pacientes con artritis reumatoidea

Revista Habanera de Ciencias Médicas, 2015
Introducción: la artritis reumatoidea es una enfermedad inflamatoria crónica y multisistémica de causa autoinmune.Los anticuerpos antipéptidos citrulinados constituyen una herramienta importante para el diagnóstico de esta enfermedad.
Goitybell Martínez Téllez, Jorge Alexis Gómez, Vicky Sánchez Rodríguez, Cira Rodríguez Pelier, Bárbara Torres Rives, Ana María Torres Lima   +5 more
doaj  

Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis

Frontiers in Immunology, 2018
Objective: Peptidylarginine deiminases (PAD) 2 and 4 are key enzymes in rheumatoid arthritis (RA) pathogenesis due to their ability to generate the protein targets of anti-citrullinated protein antibodies (ACPA).
Erika Darrah, Jon T. Giles, Ryan L. Davis, Pooja Naik, Hong Wang, Maximilian F. Konig, Laura C. Cappelli, Clifton O. Bingham, Sonye K. Danoff, Felipe Andrade   +9 more
doaj   +1 more source

Defining the role of αC helix interactions in the activation of the integrin αI domain

The FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö, Tomi T. Airenne, Jarmo Käpylä, Hongmin Tu, Eva Bligt‐Lindén, Vimal Parkash, Jyrki Heino, Tiina A. Salminen   +7 more
wiley   +1 more source

Different Clinical Relevance of Anti-Citrullinated Protein Antibodies in RA Patients. [PDF]

Dokl Biochem Biophys, 2023
Avdeeva AS, Cherkasova MV, Nasonov EL.
europepmc   +1 more source

Diffuse Skin Sclerosis in a Patient With Lung Cancer

JEADV Clinical Practice, EarlyView.
Anna‐Sophia Leven, Eva Hadaschik, Alpaslan Tasdogan   +2 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Studies on autoantigens in rheumatoid arthritis [PDF]

, 2003
This thesis describes the use of phage display for the isolation of autoantigens in rheumatoid arthritis. The potential of the technology is demonstrated by the isolation of an autoantigen, eukaryotic translation elongation factor 1a1 (eEF 1 (x 1) from a
Mewar, Devesh
core   +2 more sources

Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D

Communications Biology
Protein citrullination modification plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), and anti-citrullinated protein antibodies (ACPAs) are extensively employed for clinical diagnosis of RA.
Yang Qin, Li Liu, Yanwen Zhang, Xiaowei Chen, Jiani Zhang, Sunwang Ling, Jianguang Wang, Xinyu Yang   +7 more
doaj   +1 more source