Results 91 to 100 of about 8,957 (228)

Multicentre study to improve clinical interpretation of rheumatoid factor and anti-citrullinated protein/peptide antibodies test results

RMD Open, 2022
Background Rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA) are important biomarkers for diagnosis of rheumatoid arthritis (RA). However, there is poor harmonisation of RF and ACPA assays.
Lieve Van Hoovels, Xavier Bossuyt, Daniel Aletaha, Christopher Sjöwall, Stefanie Van den Bremt, Diego Kyburz, Alf Kastbom, Peggy Jacques, Laura Bogaert, Carolien Bonroy, Bert Vander Cruyssen, Ingmar Heijnen, Patrick Verschueren, Charlotte Dahle, Rille Pullerits, Saša Čučnik, Guenter Steiner, Daniela Sieghart, Eszter Nagy, Luca Bernasconi, Farid Benkhadra, Ann Van Liedekerke, Geert Vanheule, Johan Robbrecht, Lucy Studholme, Claudine Wirth, Rüdiger Müller, Rok Ješe, Boja Jovancevic, Emese Kiss   +29 more
doaj   +1 more source

Are rheumatoid factor, anti-citrullinated, and anti-carbamylated protein antibodies linked by post-translational modification of IgG? [PDF]

, 2016
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Accepted manuscript online: 2 August 2016No abstract is available.Support for this project was provided by the Cornwall Arthritis ...
Abedi-Valugerdi, Aho, Brink, Clavarino, Jin, Koppejan, Koro, Ling, Lugli, Rangel-Moreno, Tarcsa, Wang   +11 more
core   +1 more source

Dysbiosis‐Mediated Inflammation: A Pathophysiological Link Between Rheumatoid Arthritis and Periodontitis

Journal of Clinical Periodontology, Volume 53, Issue 3, Page 466-477, March 2026.
ABSTRACT Aim To explore mechanistic links between rheumatoid arthritis (RA) and periodontitis (PD) through the lens of subgingival microbial dysbiosis–mediated inflammation. Methods Subgingival plaque from 100 volunteers with RA and PD (RAPD), 22 with RA (RAnoPD), 18 with PD (PDnoRA) and 19 healthy controls (noRAnoPD) was analysed using 16S‐amplicon ...
Isabel Lopez‐Oliva, Iain L. Chapple, Akshay Paropkari, Shweta Saraswat, Praveen Sharma, Stefan Serban, Paola de Pablo, Karim Raza, Andrew Filer, Thomas Dietrich, Melissa Grant, Purnima S. Kumar   +11 more
wiley   +1 more source

Specificity of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis

Antibodies, 2019
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. The majority of individuals with RA are positive for the disease-specific anti-citrullinated protein antibodies (ACPAs).
Nicole H. Trier, Bettina E. Holm, Paul R. Hansen, Ole Slot, Henning Locht, Gunnar Houen   +5 more
doaj   +1 more source

Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case–control study [PDF]

, 2013
Introduction: The aim of this study was to characterize anti-citrullinated peptide antibody (ACPA) serostatus in pre-clinical rheumatoid arthritis (RA) with and without Human Leukocyte Antigen-Shared Epitope (HLA-SE) alleles.
Arkema, Elizabeth V, Costenbader, Karen H, Goldstein, Barbara L, Grodstein, Francine, Karlson, Elizabeth W, Malspeis, Susan, Robinson, William, Rosner, Bernard, Sokolove, Jeremy, Wagner, Catriona A   +9 more
core   +2 more sources

Analysis of TNFAIP3, IRAK1, and TLR4 Gene Polymorphisms in Patients With Rheumatoid Arthritis

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Objective Rheumatoid arthritis (RA) arises from a complex interplay of polygenic susceptibility, epigenetic factors, and environmental modifiers. This study investigated the correlation between RA and Tumor necrosis factor α‐induced protein 3 (TNFAIP3), Interleukin‐1 receptor‐associated kinase 1 (IRAK1), and Toll‐like receptor 4 (TLR4) gene ...
Zhenboyang Tang, Lihui Peng, Zixia Zhao, Xiping Zhou, Xiru Ling, Chunyan Huang, Jiqiang Wu, Ping Wang, Jie Chen   +8 more
wiley   +1 more source

Shared Epitope Alleles Remain A Risk Factor for Anti-Citrullinated Proteins Antibody (ACPA) – Positive Rheumatoid Arthritis in Three Asian Ethnic Groups

PLoS ONE, 2011
To investigate the associations between HLA-DRB1 shared epitope (SE) alleles and rheumatoid arthritis in subsets of rheumatoid arthritis defined by autoantibodies in three Asian populations from Malaysia.1,079 rheumatoid arthritis patients and 1,470 healthy controls were included in the study.
Too Chun-Lai, Leonid Padyukov, Jasbir Singh Dhaliwal, Emeli Lundström, Abqariyah Yahya, Nor Asiah Muhamad, Lars Klareskog, Lars Alfredsson, Per Tobias Larsson, Shahnaz Murad, Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) Study Group   +10 more
openaire   +4 more sources

Macrophage extracellular traps require peptidylarginine deiminase 2 and 4 and are a source of citrullinated antigens bound by rheumatoid arthritis autoantibodies

Frontiers in Immunology
IntroductionAnti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis, but the sources of citrullinated antigens as well as which peptidylarginine deiminases (PADs) are required for their production remain incompletely defined.
S. Janna Bashar, Caitlyn L. Holmes, Miriam A. Shelef, Miriam A. Shelef   +3 more
doaj   +1 more source

IgG antibodies to cyclic citrullinated peptides exhibit profiles specific in terms of IgG subclasses, Fc-glycans and a fab-Peptide sequence.

PLoS ONE, 2014
The Fc-glycan profile of IgG1 anti-citrullinated peptide antibodies (ACPA) in rheumatoid arthritis (RA) patients has recently been reported to be different from non-ACPA IgG1, a phenomenon which likely plays a role in RA pathogenesis.
Susanna L Lundström, Cátia Fernandes-Cerqueira, A Jimmy Ytterberg, Elena Ossipova, Aase H Hensvold, Per-Johan Jakobsson, Vivianne Malmström, Anca I Catrina, Lars Klareskog, Karin Lundberg, Roman A Zubarev   +10 more
doaj   +1 more source

Human MHC-II with Shared Epitope Motifs Are Optimal Epstein-Barr Virus Glycoprotein 42 Ligands—Relation to Rheumatoid Arthritis [PDF]

, 2018
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder of unknown etiology, which is characterized by inflammation in the synovium and joint damage.
Anna Chailyan, Bhayani, Blaschke, De Pablo, Gao, Gunnar Houen, Jose Izarzugaza, Li, Li, Lotz, Mattey, Mohl, Nicole Trier, Paolo Marcatili, Spriggs, Wang   +15 more
core   +2 more sources