Results 71 to 80 of about 5,182 (175)

Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine, Yiorgos A. Bobetsis, Benjamin C. Shayo, Peter Milgrom, Phoebus N. Madianos   +4 more
wiley   +1 more source

Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy

Journal of the Formosan Medical Association, 2018
Background/Purpose: Chronic periodontitis (CP) and rheumatoid arthritis (RA) are the most common chronic inflammatory diseases and their immunopathogenesis is similar. The aim of this study was to evaluate the effect of non-surgical periodontal treatment
Ning-Ya Yang, Chen-Ying Wang, I-Tsu Chyuan, King-Jean Wu, Yu-Kang Tu, Ching-Wen Chang, Ping-Ning Hsu, Mark Yen-Ping Kuo, Yi-Wen Chen   +8 more
doaj   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Functional studies of anti-gpi monoclonal antibodies and anti-citrullinated protein antibodies (ACPAS)

, 2023
RA is an autoimmune disease that primarily impacts joints throughout the body. The disease can result in pain, stiffness, and reduced mobility. It is a chronic disease, meaning that it lasts a long time and can worsen over time if left untreated. As the disease progresses, it can lead to joint deformity and severe pain, which can significantly impact ...
openaire   +1 more source

Sequencing of the MHC region defines HLA-DQA1 as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population [PDF]

, 2018
ABSTRACT The strong genetic contribution of the major histocompatibility complex (MHC) to rheumatoid arthritis (RA) susceptibility has been generally attributed to HLA-DRB1 . However, due to the high linkage disequilibrium in the MHC region, it is difficult to define the ‘real’ or ...
Guo, Jianping, Zhang, Tao, Cao, Hongzhi, Li, Xiaowei, Liang, Hao, Liu, Mengru, Zou, Yundong, Zhang, Yuanwei, Sun, Xiaolin, Hu, Fanlei, Du, Yan, Mo, Xiaodong, Liu, Xu, Yang, Yue, Yang, Huanjie, Wu, Xinyu, Zhang, Xuewu, Jia, Huijue, Jiang, Hui, Hou, Yong, Liu, Xin, Su, Yin, Zhang, Mingrong, Yang, Huanming, Wang, Jian, Sun, Liangdan, Liu, Liang, Padyukov, Leonid, Lai, Luhua, Yamamoto, Kazuhiko, Zhang, Xuejun, Klareskog, Lars, Xu, Xun, Li, Zhanguo   +33 more
openaire   +1 more source

Peri‐implantitis and systemic inflammation: Current evidence, biological plausibility, and research gaps

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is a biofilm‐associated inflammatory condition characterized by peri‐implant mucosal inflammation and progressive bone loss. The prevalence of peri‐implantitis continues to rise among patients with dental implants. Although peri‐implantitis and periodontitis share similar inflammatory phenotypes, histopathological ...
Yumeng Yan, Jeanie Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source

Protective and Pathogenic Antibodies to Citrullinated Antigens

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Outi Sareila, Yibo He, Zhongwei Xu, Changrong Ge, Erik Lönnblom, Rikard Holmdahl   +5 more
wiley   +1 more source

Lipoxygenase-derived oxylipins are enriched in anti-citrullinated protein antibody (ACPA)-positive individuals at risk for developing rheumatoid arthritis

Arthritis Research & Therapy
Abstract Background Rheumatoid arthritis (RA) is typically preceded by an extended preclinical period where circulating autoantibodies, particularly anti-citrullinated protein antibodies (ACPA), are detectable in the absence of clinical arthritis. Increased dietary intake of anti-inflammatory omega-3 (ω3) polyunsaturated
Liam J. O’Neil, Vidyanand Anaparti, Tanja Winter, Irene Smolik, Xiaobo Meng, Harold M. Aukema, Hani El-Gabalawy   +6 more
openaire   +3 more sources

A cross-sectional investigation into the association between and autoantibodies to citrullinated proteins in a German population

Therapeutic Advances in Musculoskeletal Disease, 2019
Background: Porphyromonas gingivalis (P.g) is unique among pathogens due to its ability to generate citrullinated proteins in an inflammatory milieu, potentially mediating the loss of immune tolerance, the production of anticitrullinated protein ...
Kolade Oluwagbemigun, Tülay Yucel-Lindberg, Thomas Dietrich, Gregory Tour, Natalia Sherina, Monika Hansson, Manuela Bergmann, Karin Lundberg, Heiner Boeing   +8 more
doaj   +1 more source

Olaparib‐associated cutaneous vasculitis in a patient with breast cancer

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Marcial Álvarez‐Salafranca, Teresa Puértolas, Adrián Diago, María Carmen Gómez‐Mateo   +3 more
wiley   +1 more source