Results 81 to 90 of about 5,182 (175)

ACPA-Induced ATP release and K+ efflux trigger NLRP3 inflammasome activation in rheumatoid arthritis

Cell Communication and Signaling
Objectives Anti-citrullinated protein antibodies (ACPA) is one of the key inducers of the initiation and maintenance of the immune-inflammatory response in Rheumatoid arthritis (RA), yet evidence is lacking on how ACPA drives the inflammatory response ...
Li Cai, Kai Zhang, Jian Gao, Bing Xiao, Meng Li, Xiangyun Meng, Zhipeng Chen, Xiaoling Chen, Shixian Chen, Juan Li   +9 more
doaj   +1 more source

Immunomodulation of RA Patients’ PBMC with a Multiepitope Peptide Derived from Citrullinated Autoantigens

Mediators of Inflammation, 2017
Citrullinated peptides are used for measuring anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA). Accumulation of citrullinated proteins in the inflamed synovium suggests that they may be good targets for inducing peripheral ...
Smadar Gertel, Gidon Karmon, Sivan Vainer, Ora Shovman, Martin Cornillet, Guy Serre, Yehuda Shoenfeld, Howard Amital   +7 more
doaj   +1 more source

Sistemik sklerozda ACPA (Anti Citrullinated Protein Antibody)`nın prognostik değeri

, 2020
49
openaire   +1 more source

Periodontal Pathogens Correlate with Rheumatoid Arthritis Disease Parameters: A Systematic Review Based on Clinical Studies

Dentistry Journal
Background: Numerous studies have found higher levels of autoantibodies including anti citrullinated protein antibodies (ACPAs), anti-cyclic citrullinated peptides (aCCP), or rheumatoid factor (RF) against periodontal microorganisms in rheumatoid ...
Luki Astuti, Sri Lelyati Chaidar Masulili, Indrayadi Gunardi, Benso Sulijaya, Yuniarti Soeroso   +4 more
doaj   +1 more source

Rheumatoid meningitis sine arthritis: An emerging cause of isolated pachymeningitis and leptomeningitis with typical features

Brain Disorders
Background and purpose: Rheumatoid meningitis (RM) is a meningeal inflammation rarely occurring during the course of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA), which are highly specific biomarkers of RA, may allow RM sine ...
Mickael Bonnan, Matthieu Faillot, Adrien Carle, Nicolas Defoor, Juliette Rocca, Gédéon Balley, Franck Bielle, Dominique Cazals-Hatem, Fahima Fernani, Carole Henry   +9 more
doaj   +1 more source

Revisiting the Link Between HLA‐DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non‐Shared Epitope Alleles *09 and *15 With High Levels of Anti–Citrullinated Peptide/Protein Antibodies

ACR Open Rheumatology
Objective Autoantibodies serve as essential clinical biomarkers and may indicate etiological mechanisms in rheumatic diseases. In light of the increasing knowledge concerning the diversity and biologic implications of anti–citrullinated peptide/protein ...
Denis Lagutkin, Luis Panaifo, Ahmad‐Fauzi Nurul‐Aain, Lena Israelsson, Monika Hansson, Karin Lundberg, Lars Alfredsson, Johan Askling, RACI consortium, Lars Klareskog, Chun‐Lai Too, Leonid Padyukov   +11 more
doaj   +1 more source

Additional file 1 of Lipoxygenase-derived oxylipins are enriched in anti-citrullinated protein antibody (ACPA)-positive individuals at risk for developing rheumatoid arthritis

Additional file1: Table S1. Effect of storage time on the levels of individual FAs – Columns highlighted in bold represent FAs that showed significant differential expression. Data was analyzed by student t test (assuming unequal variance) and q<0.05 was considered significant.
O’Neil, Liam J., Anaparti, Vidyanand, Winter, Tanja, Smolik, Irene, Meng, Xiaobo, Aukema, Harold M., El-Gabalawy, Hani   +6 more
openaire   +1 more source

A comparison of anti-cyclic citrullinated peptides (CCP3 and CCP3.1) autoantibody tests in rheumatoid arthritis

Practical Laboratory Medicine
Background: Anti-citrullinated protein antibodies (ACPA) are a specific serological biomarker used in the diagnosis of rheumatoid arthritis (RA). In clinical practice ACPA can be identified using immunoassays targeting synthetic cyclic citrullinated ...
Heather A. Nelson, Dipanwita Banerjee, Camille L. Novis, Kevin D. Deane, Marie L. Feser, Vijayalakshmi Nandakumar   +5 more
doaj   +1 more source

AB0220 ANTI-CITRULLINATED PROTEIN ANTIBODY (ACPA) POSITIVITY IS ASSOCIATED WITH REDUCED WITHDRAWAL RATES OF ABATACEPT IN RHEUMATOID ARTHRITIS BUT ONLY IN PATIENTS WHO ARE ANTI-NUCLEAR ANTIBODY (ANA) NEGATIVE [PDF]

Annals of the Rheumatic Diseases, 2021
J. Kimpton, M. Shipa, E. Hawkins, S.A. Yeoh, M. Greenwood, M. Ehrenstein   +5 more
openaire   +1 more source

Neutrophil Extracellular Trap Formation-Derived Peptidylarginine Deiminases in the Citrullination of Oral Bacteria to Promote Inflammation in Rheumatoid Arthritis. [PDF]

J Rheumatol
Acharya S, Brewer RC, Gomez AM, Younis S, Pandit M, Jahanbani S, Sharpe O, Love ZZ, Howard MC, Orange DE, Robinson WH.   +10 more
europepmc   +1 more source