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The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA [PDF]
Arthritis Research and Therapy, 2011 Abstract Introduction The antigen recognition pattern of immunoglobulin M (IgM) could, when directed against protein antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short and memory B cells against T-cell-dependent protein antigens typically ...
Leendert Trouw +2 more
exaly +4 more sources
Archives of Oral Biology, 2019 The anti-citrullinated protein antibody (ACPA), an autoantibody of rheumatoid arthritis (RA), is very specific in the diagnosis of RA and has been detected in early cases and several years before the onset of the disease. In this study, we focused on ACPA and examined whether it could be detected in saliva whether it is associated with periodontal ...
Masahiro To +2 more
exaly +3 more sources
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Fingerprinting of anti-citrullinated protein antibodies (ACPA): specificity, isotypes and subclasses
Lupus, 2015Anti-citrullinated protein antibodies (ACPA) are a family of rheumatoid arthritis (RA)-specific autoantibodies that recognize the amino acid citrulline, resulting from the post-translational modification of arginine. Peptidyl arginine deiminase, the enzyme responsible for citrullination, is present in humans in different isoforms with different tissue ...
Paola Migliorini +2 more
exaly +3 more sources
Anti-citrullinated protein antibodies (ACPA) in early rheumatoid arthritis
Modern Rheumatology, 2011Autoantibodies with the highest specificity for rheumatoid arthritis (RA) are the antibodies directed to citrulline-containing epitopes, so-called anti-citrullinated peptide/protein antibodies (ACPA). During the past decade it became clear that the presence of these antibodies was highly predictive of and specific for RA, and illustrating the ...
Suwannalai, P. +3 more
openaire +4 more sources
PLoS ONE, 2014 Antibodies against citrullinated proteins (ACPA) have been recognised as the most specific serum marker for rheumatoid arthritis. However, serum autoantibodies such as anti-nuclear antibodies have also been detected in the sera of different lymphatic malignancies without accompanying rheumatologic disease.
Viola Poeschel +2 more
exaly +5 more sources
Journal of Periodontology, 2015
Background: This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti‐citrullinated protein antibody (ACPA)‐positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations, including multiple antigen–specific ACPA ...
Shawneen M, Gonzalez +12 more
openaire +2 more sources
Background: This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti‐citrullinated protein antibody (ACPA)‐positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations, including multiple antigen–specific ACPA ...
Shawneen M, Gonzalez +12 more
openaire +2 more sources
2023
Rheumatoid arthritis (RA) is the most prevalent form of arthritis worldwide. It is characterized by chronic systemic and localized inflammation and takes a progressive course eventually leading to joint destruction if remained untreated. RA is considered to be a disease of autoimmune origin, with rheumatoid factor and anti-citrullinated protein ...
openaire +3 more sources
Rheumatoid arthritis (RA) is the most prevalent form of arthritis worldwide. It is characterized by chronic systemic and localized inflammation and takes a progressive course eventually leading to joint destruction if remained untreated. RA is considered to be a disease of autoimmune origin, with rheumatoid factor and anti-citrullinated protein ...
openaire +3 more sources
Annals of the Rheumatic Diseases, 2014
Background Susceptibility genes for anti-citrullinated peptide/protein antibodies (ACPA)-positive rheumatoid arthritis (RA) have been successfully discovered by the development of genome-wide association studies (GWAS). However, little is known about the genetic background of ACPA-negative RA.
C. Terao +17 more
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Background Susceptibility genes for anti-citrullinated peptide/protein antibodies (ACPA)-positive rheumatoid arthritis (RA) have been successfully discovered by the development of genome-wide association studies (GWAS). However, little is known about the genetic background of ACPA-negative RA.
C. Terao +17 more
openaire +1 more source
Annals of the Rheumatic Diseases, 2015
Background In rheumatoid arthritis (RA) a biological hypothesis has been proposed linking smoking with citrullination, anti-citrulline autoimmunity and ACPA-positive RA1. An interaction has been described between smoking and the HLA-DRB1 shared epitope (SE) alleles for ACPA-positive RA, but this interaction has not been investigated in relation to the ...
T.J. van Wesemael +9 more
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Background In rheumatoid arthritis (RA) a biological hypothesis has been proposed linking smoking with citrullination, anti-citrulline autoimmunity and ACPA-positive RA1. An interaction has been described between smoking and the HLA-DRB1 shared epitope (SE) alleles for ACPA-positive RA, but this interaction has not been investigated in relation to the ...
T.J. van Wesemael +9 more
openaire +1 more source
Annals of the Rheumatic Diseases, 2012
Background Anti-citrullinated protein antibodies (ACPA), the most specific markers of rheumatoid arthritis (RA), are found in approximately 50% of patients with palindromic rheumatism (PR). A significant proportion of these patients may evolve to RA. Objectives To analyze the clinical significance of serial measurements of ACPA in patients with PR ...
S.R. Cabrera-Villalba +6 more
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Background Anti-citrullinated protein antibodies (ACPA), the most specific markers of rheumatoid arthritis (RA), are found in approximately 50% of patients with palindromic rheumatism (PR). A significant proportion of these patients may evolve to RA. Objectives To analyze the clinical significance of serial measurements of ACPA in patients with PR ...
S.R. Cabrera-Villalba +6 more
openaire +1 more source