Results 41 to 50 of about 8,957 (228)

Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients [PDF]

, 2017
BACKGROUND: Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune system contributes to the development
Alessandri, Cristiano, Ciciarello, Francesco Luigi, Colasanti, Tania, Conti, Fabrizio, DI FRANCO, Manuela, Miranda, Francesca, Pecani, Arbi, Spinelli, FRANCESCA ROMANA, Valesini, Guido   +8 more
core   +1 more source

HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis

PLoS ONE, 2013
To provide a table indicating the risk for developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis (RA) according to one's HLA-DRB1 genotype.We HLA-DRB1 genotyped 857 patients with ACPA positive RA and 2178 controls from South Eastern and Eastern France and calculated Odds Ratios (OR) for developing RA for 106 of 132 ...
Balandraud, Nathalie, Picard, Christophe, Reviron, Denis, Landais, Cyril, Toussirot, Eric, Lambert, Nathalie, Telle, Emmanuel, Charpin, Caroline, Wendling, Daniel, Pardoux, Etienne, Auger, Isabelle, Roudier, Jean   +11 more
openaire   +5 more sources

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2019
Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with
Katy A. Lloyd, Gustaf Wigerblad, Gustaf Wigerblad, Peter Sahlström, Peter Sahlström, Manasa G. Garimella, Karine Chemin, Johanna Steen, Philip J. Titcombe, Philip J. Titcombe, Bianka Marklein, Diana Zhou, Ragnhild Stålesen, Elena Ossipova, Christina Lundqvist, Olov Ekwall, Olov Ekwall, Johan Rönnelid, Daniel L. Mueller, Mikael C. I. Karlsson, Mariana J. Kaplan, Karl Skriner, Lars Klareskog, Fredrik Wermeling, Vivianne Malmström, Caroline Grönwall   +25 more
doaj   +1 more source

Pitfalls in Diagnosing Seropositive Rheumatoid Arthritis: Haematologic Malignancy Presenting as an Autoimmune Disease [PDF]

Journal of Clinical and Diagnostic Research, 2018
Carcinomatous Polyarthritis (CP) is defined as the development of arthritis in association with a malignancy but distinct from that associated with metastasis or direct invasion.
Bijit Kumar Kundu, Eashan Srivastava, Vijesh Vijayan, B Manojprabhakaran, Mukesh Verma   +4 more
doaj   +1 more source

Anti-carbamylated protein antibodies as a new biomarker of erosive joint damage in systemic lupus erythematosus [PDF]

, 2018
Background: The application of more sensitive imaging techniques, such as ultrasonography (US), changed the concept of non-erosive arthritis in systemic lupus erythematosus (SLE), underlining the need for biomarkers to identify patients developing the ...
Alessandri, Cristiano, Ceccarelli, Fulvia, Cipriano, Enrica, Colasanti, Tania, Conti, Fabrizio, Mancini, Riccardo, Massaro, Laura, Natalucci, Francesco, Pendolino, Monica, Perricone, Carlo, Spinelli, Francesca Romana, Valesini, Guido   +11 more
core   +1 more source

IgA anti-citrullinated protein antibodies are associated with flares during DMARD tapering in rheumatoid arthritis

Rheumatology, 2021
Abstract Objectives A substantial proportion of RA patients flare upon withdrawal of DMARDs, and thus the definition of prognostic markers is crucial. ACPA positivity has been identified as a risk factor for flare.
Maria V Sokolova, Melanie Hagen, Holger Bang, Georg Schett, Juergen Rech, Ulrike Steffen, Judith Haschka, Matthias Englbrecht, Axel J Hueber, Bernhard Manger, Arnd Kleyer, Michaela Reiser, Stephanie Finzel, Hans-Peter Tony, Stefan Kleinert, Martin Feuchtenberger, Martin Fleck, Karin Manger, Wolfgang Ochs, Matthias Schmitt-Haendle, Joerg Wendler, Florian Schuch, Monika Ronneberger, Hanns-Martin Lorenz, Hubert Nuesslein, Rieke Alten, Winfried Demary, Joerg Henes   +27 more
openaire   +3 more sources

AB0179 INFLUENCE OF AINFLUENCE OF ANTI-CITRULLINATED PROTEIN/PEPTIDE ANTIBODIES (ACPAS)ON ARTICULAR MANIFESTATIONS, DISEASE ACTIVITY AND STRUCTURAL SEVERITY IN ALGERIAN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS [PDF]

Annals of the Rheumatic Diseases, 2021
Background: Anti-citrullinated protein/peptide antibodies (ACPA) are highly specific and sensitive markers for rheumatoid arthritis (RA). There are also suggested to have a more severe rheumatoid arthritis. Objectives: The aim of this study was to assess the influence of ACPA on disease activity, radiological severity, and functional disability in ...
F. Rahal, N. Brahumi, A. Ladjouze-Rezig, S. Lefkir   +3 more
openaire   +1 more source

Analysis of gut microbiota in rheumatoid arthritis patients. Disease-related dysbiosis and modifications induced by etanercept [PDF]

, 2018
A certain number of studies were carried out to address the question of how dysbiosis could affect the onset and development of rheumatoid arthritis (RA), but little is known about the reciprocal influence between microbiota composition and ...
D'Amelio, R, Di Rosa, R, Laganà, B, Panebianco, C, Pazienza, V, Picchianti-Diamanti, A, Salemi, S, Salerno, G, Sgrulletti, Mayla, Sorgi, Ml, Terracciano, F, Tropea, A   +11 more
core   +1 more source

Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients [PDF]

, 2013
Antibodies against citrullinated proteins are highly specific for rheumatoid arthritis (RA) and are currently used as a diagnostic marker. In this study, we wanted to quantify the numbers of T cells that react to a wide range of citrullinated proteins in
De Ceuleneer, Marlies, De Keyser, Filip, Deforce, Dieter, Elewaut, Dirk, Tilleman, Kelly, Van Steendam, Katleen   +5 more
core   +1 more source

OP0313 Molecular analysis of anti-citrullinated protein antibody variable regions indicates aberrant selection processes during acpa b-cell development [PDF]

Annals of the Rheumatic Diseases, 2018
Background Anti-citrullinated protein antibodies (ACPA) represent the most specific biomarker in Rheumatoid Arthritis (RA) and have been associated with RA pathogenesis. ACPA-IgG are heavily N-glycosylated in the variable domain. Recently, we showed that>80% of ACPA-IgG clones harbour N-glycosylation sites in their variable regions that result from ...
R.D. Vergroesen, L.M. Slot, F.S. van de Bovenkamp, M.T. Koning, T.W.J. Huizinga, T. Rispens, R.E.M. Toes, H.U. Scherer   +7 more
openaire   +1 more source