Results 61 to 70 of about 8,957 (228)

Divergent and dominant anti-inflammatory effects of patient-derived anti-citrullinated protein antibodies (ACPA) in arthritis development

Annals of the Rheumatic Diseases, 2022
AbstractAbout two thirds of rheumatoid arthritis (RA) patients develop anti-citrullinated protein antibodies (ACPA), which are a characteristic of the disease and sparsely observed in other clinical settings or in the healthy population. ACPA are used as a diagnostic criterion and often develop prior to diagnosis.
Bruno Raposo, Marcelo Afonso, Lena Israelsson, Heidi Wähämaa, Ragnhild Stålesen, Fredrik Wermeling, Aase Haj Hensvold, Caroline Grönwall, Bence Rethi, Lars Klareskog, Vivianne Malmström   +10 more
openaire   +3 more sources

Profiling anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis

Pediatric Rheumatology Online Journal, 2012
Background Anti-citrullinated protein/peptide antibodies (ACPA), have high specificity for rheumatoid arthritis (RA). Some children with juvenile idiopathic arthritis (JIA), phenotypically resemble RA and test positive for rheumatoid factor (RF) a ...
Tebo Anne E, Jaskowski Troy, Davis K, Whiting April, Clifford Bronte, Zeft Andrew, McNally Bernadette, Hill Harry R, Bohnsack John, Prahalad Sampath   +9 more
doaj   +1 more source

Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile [PDF]

, 2012
OBJECTIVES: To increase understanding of the aetiology and pathogenesis of rheumatoid arthritis (RA), genetic and environmental risk factors for RA subsets, defined by the presence or absence of different anticitrullinated protein/peptide antibodies ...
Alfredsson, Lars, Bengtsson, Camilla, Holmdahl, Rikard, Israelsson, Lena, Jiang, Xia, Kessel, Christoph, Kharlamova, Nastya, Klareskog, Lars, Källberg, Henrik, Lundberg, Karin, Padyukov, Leonid, Pollak-Dorocic, Iskra, Reed, Evan   +12 more
core   +1 more source

Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population [PDF]

Arthritis Research & Therapy, 2015
Abstract Introduction Although susceptibility genes for anti-citrullinated peptide/protein antibodies (ACPA)-positive rheumatoid arthritis (RA) have been successfully discovered by genome-wide association studies (GWAS), little is known about the genetic background of ACPA-negative RA.
Terao, Chikashi, Ohmura, Koichiro, Kochi, Yuta, Ikari, Katsunori, Okada, Yukinori, Shimizu, Masakazu, Nishina, Naoshi, Suzuki, Akari, Myouzen, Keiko, Kawaguchi, Takahisa, Takahashi, Meiko, Takasugi, Kiyoshi, Murasawa, Akira, Mizuki, Shinichi, Iwahashi, Mitsuhiro, Funahashi, Keiko, Natsumeda, Masamitsu, Furu, Moritoshi, Hashimoto, Motomu, Ito, Hiromu, Fujii, Takao, Ezawa, Kazuhiko, Matsubara, Tsukasa, Takeuchi, Tsutomu, Kubo, Michiaki, Yamada, Ryo, Taniguchi, Atsuo, Yamanaka, Hisashi, Momohara, Shigeki, Yamamoto, Kazuhiko, Mimori, Tsuneyo, Matsuda, Fumihiko   +31 more
openaire   +2 more sources

Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study [PDF]

, 2015
Background: Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response.
Apatzidou, Danae, Apazidou, Danae, Cartwright, Alison J, Culshaw, Shauna, de Pablo, Paola, Fisher, Benjamin A, Gavrila, Diana, Lappin, David F, Mattiello, Amalia, Michaud, Dominique S, Navarro, Carmen, PANICO, SALVATORE, Potempa, Jan, Quirke, Anne Marie, Riboli, Elio, Romaguera, Dora, Sacerdote, Carlotta, Tumino, Rosario, Venables, Patrick J., Vineis, Paolo   +19 more
core   +3 more sources

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA‐associated PF in an independent cohort of patients with early RA.
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

The importance of early arthritis in patients with rheumatoid arthritis [PDF]

, 2018
Rheumatoid arthritis (RA) is a systemic inflammatory disorder that manifests predominantly in the synovial joint, where it causes a chronic inflammatory process, leading to early osteoarticular destructions.
Diaconu, Camelia C, Hainarosie, Razvan, Iancu, Mihaela A, Iftimie, Georgiana, Isvoranu, Gheorghita, Marcu, Dragos, Neagu, Tiberiu P, Pantea Stoian, Anca, Socea, Bogdan, Stanescu, Ana Maria Alexandra   +9 more
core   +3 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Detection of anti-citrullinated protein antibody (ACPA) in saliva for rheumatoid arthritis using DBA mice infected with Porphyromonas gingivalis

Archives of Oral Biology, 2019
The anti-citrullinated protein antibody (ACPA), an autoantibody of rheumatoid arthritis (RA), is very specific in the diagnosis of RA and has been detected in early cases and several years before the onset of the disease. In this study, we focused on ACPA and examined whether it could be detected in saliva whether it is associated with periodontal ...
Wakako, Sakaguchi, Masahiro, To, Yuko, Yamamoto, Keitaro, Inaba, Mayumi, Yakeishi, Juri, Saruta, Shinya, Fuchida, Nobushiro, Hamada, Keiichi, Tsukinoki   +8 more
openaire   +2 more sources

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source