Results 121 to 130 of about 338,197 (344)

A Cytotoxic Indazole‐based Gold(III) Carboxamide Pincer Complex Targeting DNA Through Dual Binding Modes of Groove Binding and Alkylation

Chemistry – A European Journal, EarlyView.
Toward new gold(III) anticancer agents. Herein, we report on an indazole‐based gold(III) carboxamide pincer complex exhibiting significant cytotoxicity, likely mediated through dual interactions with DNA. Mechanistic investigations suggest that the complex binds to the DNA and forms specific interactions with nucleotide bases.
Rufaro Razuwika, Sheldon Sookai, Ruth Aronson, Mandeep Kaur, Orde Q. Munro   +4 more
wiley   +1 more source

Discovery of N-arylsulfonyl-3-acylindole benzoyl hydrazone derivatives as anti-HIV-1 agents

Brazilian Journal of Pharmaceutical Sciences, 2019
The discovery and development of novel inhibitors with activity against variants of human immunodeficiency virus type 1 (HIV-1) is pivotal for overcoming treatment failure.
Zhiping Che, Yuee Tian, Shengming Liu, Mei Hu, Genqiang Chen   +4 more
doaj   +1 more source

Discovery of an L-like Configuration for 3'-Fluoro-5'-norcarbonucleoside Phosphonates as Potent Anti-HIV Agents. [PDF]

ChemMedChem, 2022
Geant PY, Kaci M, Uttaro JP, Périgaud C, Mathé C.   +4 more
europepmc   +1 more source

Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population [PDF]

, 2016
Background: The percentage of older HIV-positive patients is growing, with an increase in age-related comorbidities and concomitant medication. Objectives: To quantify polypharmacy and profile types of non-antiretroviral drugs collected at community ...
Armesto-Gómez, F.J., Compaired-Turlán, V., Crusells-Canales, M., Gimeno-Gracia, M., Rabanaque-Hernández, M.J.   +4 more
core   +2 more sources

Probabilistic Agent Programs [PDF]

arXiv, 1999
Agents are small programs that autonomously take actions based on changes in their environment or ``state.'' Over the last few years, there have been an increasing number of efforts to build agents that can interact and/or collaborate with other agents.
arxiv  

Immunological and Toxicological Assessment of Triterpenoid Saponins Bearing Lewis‐X‐ and QS‐21‐Based Trisaccharides

Chemistry – A European Journal, EarlyView.
The synthesis of betulinic acid and echinocystic acid saponins featuring QS‐21 minimal immunogenic motif is reported. These chimeric saponins, together with previously synthesized Lewis‐X‐containing triterpenoid saponins and a rhamnose‐modified saponin, were assessed for their toxicological and immunological profiles in wild‐type and/or hDC‐SIGN ...
Oscar Javier Gamboa Marin, Yasmine Adda‐Bouchard, Balla Sylla, Nitish Verma, Tania Charpentier, Maya Huber, Guillaume Lopez, André Pichette, Alain Lamarre, Charles Gauthier   +9 more
wiley   +1 more source

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Small, Volume 18, Issue 51, December 22, 2022., 2022
Hyaluronic acid (HA) is a very promising polysaccharide for biomedical applications. This review provides a comprehensive overview of the development of nanoparticulate systems by HA‐based polyelectrolyte complexation. The main achievements and applications for the delivery of active substances or the construction of multifunctional platforms are ...
Huu Van Le, Didier Le Cerf
wiley   +1 more source

Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors

European Journal of Medicinal Chemistry Reports
Acquired immune deficiency syndrome (AIDS) diseases despite the efficacy of anti-HIV therapy, remain one of the human's most serious problems. Hence, the introduction of novel anti-HIV agents as first-line therapy is still required. HIV integrase lacking
Nafiseh Karimi, Amirreza Dowlati Beirami, Rouhollah Vahabpour Roudsari, Zahra Hajimahdi, Afshin Zarghi   +4 more
doaj  

Non-clinical considerations for supporting accelerated inclusion of pregnant women in pre-licensure clinical trials with anti-HIV agents. [PDF]

J Int AIDS Soc, 2022
Greupink R, van Hove H, Mhlanga F, Theunissen P, Colbers A.   +4 more
europepmc   +1 more source

Antiviral activity of organic molecules having sulfonamide moiety: An insight of recent research [PDF]

, 2018
Sulfonamide derivatives are well known for their antibacterial activity as manifested by ‘Sulfa Drugs’, for example, sulfamethoxazole etc. In addition, they are associated with a large number of pharmacological activities such as anti-microbial, anti ...
Aslam, S., Kanwal, A., Khan, B.A., Mohsin, N.ul A., Saddique, F.A.   +4 more
core   +1 more source