Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors [PDF]
, 2018 Indolylarylsulfones are a potent class of human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors. In this review, the structure activity relationship (SAR) studies to improve the profile of sulfone L-737,126 discovered by ...
Famiglini, V., Silvestri, R.
core +1 more source
An agent framework for dynamic agent retraining: Agent academy [PDF]
In B. Stanford-Smith, E. Chiozza, and M. Edin, editors, Challenges
and Achievements in e-business and e-work, pages 757-764, Prague, Czech
Republic, October 2002. IOS Press, 2004 Agent Academy (AA) aims to develop a multi-agent society that can train new agents for specific or general tasks, while constantly retraining existing agents in a recursive mode. The system is based on collecting information both from the environment and the behaviors of the acting agents and their related successes/failures to generate a body of data,
arxiv
Constructive agents nullify the ability of destructive agents to foster cooperation in public goods games [PDF]
Chaos: An Interdisciplinary Journal of Nonlinear Science 34.10
(2024)Existing studies have revealed a paradoxical phenomenon in public goods games, wherein destructive agents, harming both cooperators and defectors, can unexpectedly bolster cooperation. Building upon this intriguing premise, our paper introduces a novel concept: constructive agents, which confer additional benefits to both cooperators and defectors.
arxiv +1 more source
Lamellarin D Acts as an Inhibitor of Type I Collagen Production
ChemMedChem, EarlyView.COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno +19 more
wiley +1 more source
Small Molecules of Natural Origin as Potential Anti-HIV Agents: A Computational Approach. [PDF]
Life (Basel), 2021 Crisan L, Bora A.
europepmc +1 more source
Methods and Compositions for Optimizing Blood and Tissue Stability of Camptothecin and Other Albumin-Binding Therapeutic Compounds [PDF]
, 2010 The present invention provides methods and formulations for optimizing the anti-cancer and anti-HIV activities of a camptothecin drug, including camptothecin and its related analogs including 9-aminocamptothecin and 9-nitrocamptothecin.
Burke, Thomas G., Carter, Daniel C.
core +1 more source
Structure-based virtual screening, ADMET profiling, and molecular dynamics simulation studies on HIV-1 protease for identification of active phytocompounds as potential anti-HIV agents [PDF]
, 2022 Madhusmita Panda +2 more
openalex +1 more source
An informational study of the evolution of codes and of emerging concepts in populations of agents [PDF]
arXiv, 2015 We consider the problem of the evolution of a code within a structured population of agents. The agents try to maximise their information about their environment by acquiring information from the outputs of other agents in the population. A naive use of information-theoretic methods would assume that every agent knows how to "interpret" the information
arxiv
Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”
ChemMedChem, EarlyView.This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley +1 more source
Novel 2-(Diphenylmethylidene) Malonic Acid Derivatives as Anti-HIV Agents: Molecular Modeling, Synthesis and Biological Evaluation. [PDF]
Iran J Pharm Res, 2022 Lotfaliei M +6 more
europepmc +1 more source