Results 131 to 140 of about 295,334 (238)

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

ChemistryOpen, EarlyView.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas, Gobind Kumar, Sanjeev Dhawan, Talent Makhanya, Parvesh Singh   +4 more
wiley   +1 more source

Studies Concerned with the Structure and Synthesis of the Anti‐viral Tropolone Glycoside Liriosmaside A

ChemistryOpen, EarlyView.
The core of the anti‐viral troponoid natural product liriosmaside A lacking the 3‐hydroxy‐3‐methylglutaric acid (HMGA) side‐chain at C6′ has been prepared. The early steps involved the gem‐dibromocyclopropane‐mediated ring‐expansion of a readily‐obtained Robinson annulation product.
Qi Chen, Yaping Zhan, Michael G. Gardiner, Zeinab G. Khalil, Amila A. Dewa, Thulasi Sritharan, Robert J. Capon, Ping Lan, Shen Tan, Martin G. Banwell   +9 more
wiley   +1 more source

SiO2@Benzothiazole‐Cl@Fc as an Efficient Heterogeneous Catalyst for the Synthesis of 1,3,5‐Trisubstituted Pyrazoles by A3 Coupling

ChemistryOpen, EarlyView.
This research introduces the preparation and analysis of a newly heterogeneous catalyst developed silica nanospheres supporting a ferrocene‐containing ionic liquid (SiO2@Benzothiazole‐Cl@Fc) for the A3 coupling reaction. The catalyst facilitates the efficient synthesis of 1,3,5‐trisubstituted pyrazoles from aromatic hydrazides, aldehydes, and aromatic ...
Fadhil Faez Sead, Vicky Jain, Roopashree R, Aditya Kashyap, Suman Saini, Girish Chandra Sharma, Pushpa Negi Bhakuni, Mosstafa Kazemi, Ramin Javahershenas   +8 more
wiley   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Pterostilbene Exhibits Broad‐Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV‐A71 Challenge

Phytotherapy Research, EarlyView.
Pterostilbene (Pte) binds to the VP1 hydrophobic pocket of enteroviruses, stabilizing the viral capsid and preventing uncoating and RNA release. In vitro, Pte inactivates virions and impairs viral attachment, entry, and replication. In vivo, oral administration of Pte in hSCARB2‐transgenic mice reduces clinical symptoms and improves survival ...
Kuan‐Ting Chuang, Siao‐Cian Pan, Bor‐Luen Chiang, Shih‐Hsun Chen, Min‐Hsiung Pan, Yu‐Li Chen, Cheng‐Sheng Lin, Chun‐Kai Pan, Jing‐Yi Lin, Yu‐Li Lin   +9 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

NIR‐Induced Photoswitching Hybrid DNA Nanoconstruct‐Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate

Small, EarlyView.
NIR‐mediated photo‐switching drug delivery system for the remote‐control differentiation of NSCs. Left: NIR‐mediated curcumin release is induced by NIR‐to‐UV photon upconversion in a photo‐controllable manner. Curcumin is bound in the minor groove of the synthesized DNA construct containing AAP photo‐switchers. Right: The rational design of several AAP
Thanapat Pongkulapa, Ji Hye Yum, Callan D. McLoughlin, Brandon Conklin, Tomotaka Kumagai, Li Ling Goldston, Hiroshi Sugiyama, Soyoung Park, Ki‐Bum Lee   +8 more
wiley   +1 more source

ABT-263, a BCL-2 inhibitor, selectively eliminates latently HIV-1-infected cells without viral reactivation. [PDF]

PLoS One
Kang JE, Seo HW, Kim DE, Shin YH, Bae S, Yoon CH.   +5 more
europepmc   +1 more source

Opsoclonus‐Myoclonus: Not Always Paraneoplastic

Movement Disorders Clinical Practice, EarlyView.
Fernanda Lustosa Cabral Gomez, Luiz José Malta Gaia Ferreira Júnior, Sofia Mônaco Gama, Fabiano Moulin de Moraes, Flávio Moura Rezende Filho   +4 more
wiley   +1 more source

Design Principles of Nanosensors for Multiplex Detection of Contaminants in Food

Small, EarlyView.
This review discusses recent advancements in nanoparticle‐based nanosensors for multiplex detection of food contaminants, focusing on toxins and pathogens. It highlights the design principles, sensitivity, and selectivity of these sensors, offering insights into their practical applications for food safety monitoring and inspiring future innovations ...
Yang Zhang, Shipeng Gao, Haoran Li, Tianxi Yang, Kaiyi Zheng, Zhing Ming Guo, Jiyong Shi, Xiaowei Huang, Xiaobo Zou, Pierre Picchetti, Frank Biedermann   +10 more
wiley   +1 more source