Results 21 to 30 of about 492,595 (235)
Safety of antiretrovirals in pregnacy [PDF]
nema
Dragović Gordana+5 more
doaj +1 more source
The Anti-HIV Actions of 7- and 10-Substituted Camptothecins
Camptothecin (CPT), a traditional anti-tumor drug, has been shown to possess anti-HIV-1 activity. To increase the antiviral potency, the anti-HIV activities of two CPT derivatives, 10-hydroxy-CPT and 7-hydroxymethyl-CPT, were evaluated in vitro.
Yu-Ye Li+5 more
doaj +1 more source
The immune checkpoint programmed cell death protein 1 (PD-1) plays a major role in T cell exhaustion in cancer and chronic HIV infection. The inhibitor of apoptosis protein antagonist Debio 1143 (D1143) enhances tumor cell death and synergizes with anti ...
Michael Bobardt+5 more
doaj +1 more source
Electrochemistry of anti-HIV agents
Square wave voltammetry has been used to study the electrochemical behaviour of anti-HIV drugs in aqueous solutions. The oxidation reaction of Carbovir (1) at a Pt microelectrode occurs at 1.12 V versus SCE and the peak current is proportional to the concentration. An electroanalytical technique for the determination of trace concentrations of Carbovir
Yufei Cheng+3 more
openaire +2 more sources
Oropharyngeal Candidosis in HIV-Infected Patients—An Update
Oropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found in HIV-infected patients, even in the twenty-first century. Candida albicans is the main pathogen, but other Candida species have been isolated.
Shankargouda Patil+4 more
doaj +1 more source
The AIDS pandemic is still of importance. HIV-1 and HIV-2 are the causative agents of this pandemic, and in the absence of a viable vaccine, drugs are continually required to provide quality of life for infected patients.
Xujie Zhang+13 more
doaj +1 more source
Antiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects.
Pratiksha Jadaun+8 more
doaj +1 more source
Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins
The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral RNA and is highly conserved among many strains of the virus. It forms a conical structure by assembling oligomers of capsid (CA) proteins. CA dysfunction is expected
Takuya Kobayakawa+12 more
doaj +1 more source
Strategies in the Design of Prodrugs of Anti-HIV Agents
Control of AIDS requires development of special therapeutic strategies in order to reduce the level of monocyte/macrophage HIV infection, to prevent spread of HIV within the monocyte/macrophage reservoir, to maintain a therapeutically effective drug concentration in sanctuaries such as the brain and to overcome the problem of cellular resistance ...
Calogeropoulou, Theodora+3 more
openaire +3 more sources
Investigation of Seroprevalence of Hepatitis B, Hepatitis C and HIV in Hemodialysis Patients
Aim: Impairments in the immune system of patients undergoing HD cause patients to be more sensitive to infection agents. The purpose of this study; to determine the seroprevalance of HBV, HCV and HIV in patients undergoing hemodialysis treatment ...
Duygu Fındık+4 more
doaj +2 more sources