Results 21 to 30 of about 686,239 (385)

The Anti-HIV Actions of 7- and 10-Substituted Camptothecins

Molecules, 2009
Camptothecin (CPT), a traditional anti-tumor drug, has been shown to possess anti-HIV-1 activity. To increase the antiviral potency, the anti-HIV activities of two CPT derivatives, 10-hydroxy-CPT and 7-hydroxymethyl-CPT, were evaluated in vitro.
Yu-Ye Li, Shi-Wu Chen, Liu-Meng Yang, Rui-Rui Wang, Wei Pang, Yong-Tang Zheng   +5 more
doaj   +1 more source

New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities [PDF]

, 2015
CXCR4 is a target of growing interest for the development of new therapeutic drugs and imaging agents as its role in multiple disease states has been demonstrated.
Archibald, Stephen J., Boschetti, Frederic, Boschetti, Frédéric, Cawthorne, Christopher, D'huys, Thomas, Denat, Franck, Desogere, Pauline, Désogère, Pauline, Désogère, Pauline, D‘huys, Thomas, Goze, Christine, Maecke, Helmut R., Maëcke, Helmut R., Poty, Sophie, Schols, Dominique   +14 more
core   +1 more source

The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice.

PLoS ONE, 2020
The immune checkpoint programmed cell death protein 1 (PD-1) plays a major role in T cell exhaustion in cancer and chronic HIV infection. The inhibitor of apoptosis protein antagonist Debio 1143 (D1143) enhances tumor cell death and synergizes with anti ...
Michael Bobardt, Joseph Kuo, Udayan Chatterji, Norbert Wiedemann, Gregoire Vuagniaux, Philippe Gallay   +5 more
doaj   +1 more source

Oropharyngeal Candidosis in HIV-Infected Patients—An Update

Frontiers in Microbiology, 2018
Oropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found in HIV-infected patients, even in the twenty-first century. Candida albicans is the main pathogen, but other Candida species have been isolated.
Shankargouda Patil, Barnali Majumdar, Sachin C. Sarode, Gargi S. Sarode, Kamran H. Awan   +4 more
doaj   +1 more source

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators

Molecules, 2022
The AIDS pandemic is still of importance. HIV-1 and HIV-2 are the causative agents of this pandemic, and in the absence of a viable vaccine, drugs are continually required to provide quality of life for infected patients.
Xujie Zhang, Lin Sun, Shujing Xu, Xiaoyu Shao, Ziyi Li, Dang Ding, Xiangyi Jiang, Shujie Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan   +13 more
doaj   +1 more source

Antiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection

BMC Complementary Medicine and Therapies, 2023
Antiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects.
Pratiksha Jadaun, Prachibahen Shah, R. Harshithkumar, Madhukar S. Said, Shubhangi P. Bhoite, Sowmya Bokuri, Selvan Ravindran, Neetu Mishra, Anupam Mukherjee   +8 more
doaj   +1 more source

Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins

Biomolecules, 2021
The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral RNA and is highly conserved among many strains of the virus. It forms a conical structure by assembling oligomers of capsid (CA) proteins. CA dysfunction is expected
Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato, Hirokazu Tamamura   +12 more
doaj   +1 more source

Treatment of Halogen Bonding in the OPLS-AA Force Field; Application to Potent Anti-HIV Agents.

Journal of Chemical Theory and Computation, 2012
W. L. Jorgensen, Patric Schyman
semanticscholar   +3 more sources

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

Antioxidant Capacity and Antimicrobial Activity of Commercial Samples of Guava Leaves (\u3cem\u3ePsidium guajava\u3c/em\u3e) [PDF]

, 2020
Psidium guajava is a small tree native to South and Central America. Guava leaves have traditionally been used for treating different illnesses. These benefits can be attributed to phenolics and flavonoids produced by guava.
Alsaidi, Sahar, Bonnaire, Thierry, Cornejal, Nadjet, Cruz Rodriguez, Gearoff, Cruz, Victor, Fernandez Romero, Jose, Gomez Ramirez, Aned, Koroch, Adolfina, Melo, Claudia, Priano, Christine, Sorel, Victor, Zydowsky, Thomas M   +11 more
core   +2 more sources