Results 41 to 50 of about 492,595 (235)
Molecular Therapy: Nucleic Acids, 2015 Designed molecular scaffolds have been proposed as alternative therapeutic agents against HIV-1. The ankyrin repeat protein (AnkGAG1D4) and the zinc finger protein (2LTRZFP) have recently been characterized as intracellular antivirals, but these ...
Wannisa Khamaikawin +12 more
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Retinoids: novel potential therapeutics in the pursuit of HIV-1 cure
Frontiers in Virology, 2022 Human immunodeficiency virus (HIV) infection remains a global epidemic. While antiretroviral therapy (ART) suppresses viral replication, cessation of ART results in viral rebound necessitating lifelong treatment.
Andrew Purssell +5 more
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Molecules, 2023 Four new xanthones, cratocochinones A–D (1–4), together with eight known analogues (5–12), were isolated from the stems and leaves of Cratoxylum cochinchinense.
Yong Zhang +8 more
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Frontiers in Pharmacology, 2019 The combination of three or more antiviral agents that act on different targets is known as highly active antiretroviral therapy (HAART), which is widely used to control HIV infection. However, because drug resistance and adverse effects occur after long-
Jiayin Qiu +12 more
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Anti-HIV lectins and current delivery strategies
AIMS Molecular Science, 2018 Lectins, a class of carbohydrate binding agents (CBAs), have been widely studied for their potential antiviral activity. In general, lectins exert their anti-HIV microbicidal activity by binding to viral envelope glycoproteins which hinders a proper ...
Fohona S. Coulibaly +2 more
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Coumarins as anti-HIV agent and correlation with COVID-19: an overview
HIV & AIDS Review. International Journal of HIV-Related Problems, 2023 Acquired immunodeficiency syndrome (AIDS) is an immunosuppressive disease caused by human immunodeficiency virus (HIV), and leads to infection and malignance, which are life threatening.
Vikas Kumar +3 more
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Medycyna PracyPresented is the case of a nurse who had 4 occupational exposures to potentially infectious material between December 2020 and June 2022. In 2 of the cases, the source patient was unknown, so pharmacological HIV post-exposure prophylaxis was implemented (
Mateusz Bożejko, Karolina Olech
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Computational Design of Hypothetical New Peptides Based on a Cyclotide Scaffold as HIV gp120 Inhibitor. [PDF]
PLoS ONE, 2015 Cyclotides are a family of triple disulfide cyclic peptides with exceptional resistance to thermal/chemical denaturation and enzymatic degradation. Several cyclotides have been shown to possess anti-HIV activity, including kalata B1 (KB1).
Apiwat Sangphukieo +4 more
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Molecules, 2016 The search for new molecular constructs that resemble the critical two-metal binding pharmacophore and the halo-substituted phenyl functionality required for HIV-1 integrase (IN) inhibition represents a vibrant area of research within drug discovery.
Guan-Nan Liu +7 more
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Marine Algae Metabolites as Promising Therapeutics for the Prevention and Treatment of HIV/AIDS
Metabolites, 2019 This review presents an analysis of works devoted to the anti-human immunodeficiency virus (HIV) activity of algae metabolites—sulfated polysaccharides (fucoidans, carrageenans), lectins, laminarans, and polyphenols.
Natalya N. Besednova +7 more
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