Results 51 to 60 of about 492,595 (235)

Seroprevalence of Hepatitis B, Hepatitis C and HIV in Intensive Care Unit Patients

Türk Yoğun Bakim Derneği Dergisi, 2015
Objective: Intensive care unit (ICU) personnel are at high risk for infectious agents during interventional procedures, surgical procedures, and processes such as injection.
Hakan Bayır, İsa Yıldız, Esra Koçoğlu, Adem Deniz Kurt, Hasan Koçoğlu   +4 more
doaj   +1 more source

Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Nature Communications, 2017
Tuberculosis (TB) remains one of the world’s deadliest communicable diseases, novel anti-TB agents are urgently needed due to severe drug resistance and the co-epidemic of TB/HIV.
Junying Ma, Hongbo Huang, Yunchang Xie, Zhiyong Liu, Jin Zhao, Chunyan Zhang, Yanxi Jia, Yun Zhang, Hua Zhang, Tianyu Zhang, Jianhua Ju   +10 more
doaj   +1 more source

Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils

Biology Open, 2015
Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity.
Laura M. Castellano, Rebecca M. Hammond, Veronica M. Holmes, Drew Weissman, James Shorter   +4 more
doaj   +1 more source

Selectivity of kinases on the activation of tenofovir, an anti-HIV agent

European Journal of Pharmaceutical Sciences, 2013
Nucleoside analogues, used in HIV-therapy, need to be phosphorylated by cellular enzymes in order to become potential substrates for HIV reverse transcriptase. After incorporation into the viral DNA chain, because of lacking of their 3'-hydroxyl groups, they stop the elongation process and lead to the death of the virus. Phosphorylation of the HIV-drug
Varga, Andrea, Gráczer, Eva, Chaloin, Laurent, Liliom, Károly, Závodszky, Péter, Lionne, Corinne, Vas, Mária   +6 more
openaire   +3 more sources

Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture

Bioinorganic Chemistry and Applications, 2006
The cerium Ce(III), lanthanum La(III), and neodymium Nd(III) complexes with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one (warfarin) (W) and 3,3′-benzylidenebis[4-hydroxycoumarin] (1) were synthesized and studied for the first time for ...
Ilia Manolov, Sevda Raleva, Petya Genova, Alexey Savov, Liliana Froloshka, Daniela Dundarova, Radka Argirova   +6 more
doaj   +1 more source

Discovery of N-arylsulfonyl-3-acylindole benzoyl hydrazone derivatives as anti-HIV-1 agents

Brazilian Journal of Pharmaceutical Sciences, 2019
The discovery and development of novel inhibitors with activity against variants of human immunodeficiency virus type 1 (HIV-1) is pivotal for overcoming treatment failure.
Zhiping Che, Yuee Tian, Shengming Liu, Mei Hu, Genqiang Chen   +4 more
doaj   +1 more source

Discovery of an L-like Configuration for 3'-Fluoro-5'-norcarbonucleoside Phosphonates as Potent Anti-HIV Agents. [PDF]

ChemMedChem, 2022
Geant PY, Kaci M, Uttaro JP, Périgaud C, Mathé C.   +4 more
europepmc   +1 more source

In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes.

PLoS ONE, 2012
Endogenous serine protease inhibitors (serpins) are anti-inflammatory mediators with multiple biologic functions. Several serpins have been reported to modulate HIV pathogenesis, or exhibit potent anti-HIV activity in vitro, but the efficacy of serpins ...
Mohammed Asmal, James B Whitney, Corinne Luedemann, Angela Carville, Robert Steen, Norman L Letvin, Ralf Geiben-Lynn   +6 more
doaj   +1 more source

Non-clinical considerations for supporting accelerated inclusion of pregnant women in pre-licensure clinical trials with anti-HIV agents. [PDF]

J Int AIDS Soc, 2022
Greupink R, van Hove H, Mhlanga F, Theunissen P, Colbers A.   +4 more
europepmc   +1 more source

Small Molecules of Natural Origin as Potential Anti-HIV Agents: A Computational Approach. [PDF]

Life (Basel), 2021
Crisan L, Bora A.
europepmc   +1 more source