Results 61 to 70 of about 1,954,791 (139)
AMPK‐Mediated Lipid Metabolic Reprogramming in Cancer: From Mechanisms to Targeted Therapies
Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.ABSTRACT AMP‐activated protein kinase (AMPK), a key regulator of cellular energy metabolism, is activated under conditions of energy stress to restore metabolic homeostasis by promoting catabolic pathways and inhibiting anabolic processes such as lipid synthesis. Multiple key molecules involved in lipid metabolism are regulated by AMPK, and its role in
Yuying Chen, Wen Liu, Bing Luo
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li +6 more
wiley +1 more source
Dermatomyositis Like Presentation of Anti‐HMGCR Immune Mediated Necrotising Myopathy
JEADV Clinical PracticeExtramuscular manifestations of anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) immune‐mediated necrotising myopathy (IMNM) are rare and often overlooked because they are overshadowed by predominant muscular symptoms.
Lionel Leblanc +4 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.• EThcD‐sceHCD‐MS/MS and updated PANDA software decode IgG N‐glycosylation in IIMs. • Unsupervised clustering reveals three novel glyco‐endotypes matching clinical phenotypes. • A seven‐glycopeptide model enables robust endotype prediction beyond conventional subtypes.
Tong Wu +9 more
wiley +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2016 Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibody is a newly recognized autoantibody, which is associated with the use of statins and is considered as an immunological marker of necrotizing autoimmune myopathy (NAM).
Jing-jing LUO +5 more
doaj
MedComm, Volume 7, Issue 10, October 2026.CH25H deficiency permits optimal dendritic cell activation following BCG exposure, characterized by increased IL‐12p70 production. In vivo, CH25H deficiency promotes enhanced BCG‐mediated protection and sustained IL‐2 producing T cell response. ABSTRACT Bacillus Calmette‐Guérin (BCG) remains the only licensed vaccine for tuberculosis (TB), yet its ...
Hagyu Kim +6 more
wiley +1 more source
Statin-Associated Autoimmune Myopathy: Current Perspectives
Therapeutics and Clinical Risk Management, 2020 Eleni Tiniakou Johns Hopkins University School of Medicine, Department of Medicine, Division of Rheumatology, Baltimore, MD, USACorrespondence: Eleni TiniakouJohns Hopkins University School of Medicine, 5200 Eastern Avenue, Mason Lord, Center Tower ...
Tiniakou E
doaj
, 2017 Autoimmune myopathies (AIM), classically called myositis or idiopathic inflammatory myopathies, represent a group of diseases characterized by clinical, histopathologic and biologic properties.
Bergua, Cecile
core
BiomedicinesImmune-mediated necrotizing myopathy (IMNM) is a distinct subtype of idiopathic inflammatory myopathies (IIMs), classified by serum autoantibody status into anti-signal recognition particle (anti-SRP)-positive, anti-3-hydroxy-3-methylglutaryl-coenzyme A ...
Xiaoke Wu +8 more
doaj +1 more source
Kaohsiung Journal of Medical Sciences, 2020 Immune‐mediated necrotizing myopathy (IMNM) has emerged as a new subgroup of idiopathic inflammatory myopathy in the past decade, associated with the presence of two autoantibodies against signal recognition particle and 3‐hydroxy‐3‐methylglutaryl ...
Wen‐Chen Liang +7 more
doaj +1 more source