Results 81 to 90 of about 1,954,791 (139)

Treatment of refractory immune-mediated necrotizing myopathy with efgartigimod

Frontiers in Immunology
ObjectiveWe aimed to explore the efficacy and safety of efgartigimod in patients with refractory immune-mediated necrotizing myopathy (IMNM).MethodsThis open-label pilot observational study included seven patients with refractory IMNM, all of whom ...
MengTing Yang, JingChu Yuan, YiKang Wang, HongJun Hao, HongJun Hao, Wei Zhang, Wei Zhang, ZhaoXia Wang, ZhaoXia Wang, Yun Yuan, Yun Yuan, YaWen Zhao   +11 more
doaj   +1 more source

MOESM5 of Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients

, 2020
Additional file 5 : Table S5. Chronology of events, from disease onset to maintenance therapy, in patients with anti-HMGCR myopathy presenting with normal strength (N ...
Baptiste Hervier (7069286), Jean-Paul Makhzoum (8272101), Hélène Couture (8272119), Jean-Luc Senécal (84282), Alain Meyer (2383465), Anne-Marie Mansour (8272089), Jessica Nehme (8272098), Ira Targoff (8272122), Marvin Fritzler (3464078), Marie Hudson (289434), Isabelle Deschênes (845781), Farah Zarka (8272104), Sandra Chartrand (8272095), Catherine Isabelle (287264), Yves Troyanov (84281), Jason Karamchandani (4544797), Sandrine Larue (3433376), Jean-Pierre Raynauld (63745), Sara Hussein (105413), Rami Massie (8272116), Geneviève Oligny-Longpré (8272077), Marianne Landry (8272107), Océane Landon-Cardinal (8272080), Jose Ferreira (6338123), Eric Rich (247418), Edith Villeneuve (4282729), Benjamin Ellezam (8272113), Sabrina Hoa (8272083), Josiane Bourré-Tessier (8272086), Vincent Morin (5736995), Jean-Richard Goulet (8272092), Julie Drouin (8272074), Erin O’Ferrall (8272110), Valérie Leclair (3141204)   +33 more
core   +1 more source

Cholesterol biosynthesis induced by radiotherapy inhibits cGAS–STING activation and contributes to colorectal cancer treatment resistance

Experimental and Molecular Medicine
Radiotherapy-induced DNA damage can lead to apoptotic cell death and trigger an anti-tumor immune response via the cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway, which senses cytoplasmic double-stranded DNA.
Lijun Zhu, Zhaohui Tang, Wen Jiang, Yuwen Dong, Xiaofei Li, Kai Huang, Tiancong Wu, Lingyan Xu, Wenjie Guo, Yanhong Gu   +9 more
doaj   +1 more source

Gentiopicroside inhibits HMGCR/NF-κB pathway to alleviate renal fibrosis

BMC Complementary Medicine and Therapies
Background Gentiopicroside (GSP) has been shown to effectively ameliorate renal fibrosis (RF), yet its underlying mechanisms are poorly characterized. This study investigates how GSP alleviates RF using RNA-seq and in vitro experiments.
Qingqing Xu, Feng Zhu, Ping Song, Yuemin Fang, Zhiqing Bai, Tao Cheng   +5 more
doaj   +1 more source

Interlaboratory comparison of immunoprecipitation-based testing for myositis-specific autoantibodies

Frontiers in Immunology
IntroductionMyositis-specific autoantibodies (MSAs) are clinically important biomarkers that help classify idiopathic inflammatory myopathies and guide clinical management, but reliable detection remains challenging.
Kimberly Loh, Georgina R Harvey, Xavier Bossuyt, Anna Brusch, Chris Bundell, Mei Cheng, Masataka Kuwana, Hui Lu, Birthe Michiels, Johan Ronnelid, Ira N Targoff, Akira Yoshida, Neil J McHugh, Sarah L Tansley   +13 more
doaj   +1 more source

Predictive value of myositis antibodies: role of semiquantitative classification and positivity for more than one autoantibody

RMD Open
Objectives We assessed the positive predictive value (PPV) of 17 myositis antibodies for having a diagnosis of myositis and other myositis-spectrum conditions (interstitial lung disease (ILD), connective tissue diseases (CTD), malignancy) and evaluated ...
Anne M Kerola, Arno Hänninen, Annukka Pietikäinen, Julia Barantseva, Annaleena Pajander   +4 more
doaj   +1 more source

Anti-HMGCR Antibody–Related Necrotizing Autoimmune Myopathy Mimicking Muscular Dystrophy

, 2017
Introduction Necrotizing autoimmune myopathies (NAMs) are acquired myopathies with myofibrillar necrosis and weak or absent inflammatory component, sometimes associated with anti-signal recognition particle (SRP) or 3-hydroxy-3 ...
Vincent Tiffreau, Jaillette, Emmanuelle, Vermersch, Patrick, Emmanuelle Jaillette, Fabienne Jouen, Jouen, Fabienne, Gisèle Bonne, Bonne, Gisèle, Nelson, Isabelle, Isabelle Nelson, Norma Romero, Tard, Céline, Vallée, Louis, Cuisset, Jean-Marie, Rabah Yaou, Patrick Vermersch, Claude-Alain Maurage, Tiffreau, Vincent, Nguyen, Sylvie, Sylvie Nguyen, Louis Vallée, Jean-Marie Cuisset, Maurage, Claude-Alain, Céline Tard, Ben Yaou, Rabah, Romero, Norma   +25 more
core   +1 more source

Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses

Heliyon
Momordica charantia, Nigella sativa, and Anethum graveolens are established medicinal plants possessing noted anti-diabetic and anti-obesity properties.
Rajashekar S. Chavan, Nayeem A. Khatib, M.G Hariprasad, Vishal S. Patil, Moqbel Ali Moqbel Redhwan   +4 more
doaj   +1 more source

Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins

Rheumato
Statins are effective drugs for lowering cholesterol and reducing cardiovascular risk. Rarely, they can trigger autoimmune myopathies like immune-mediated necrotizing myopathy (IMNM), associated with anti-HMGCR antibodies.
Luis Angel Montero Furelos, Clara Fernandez Peña, Beatriz San Millan Tejedor   +2 more
doaj   +1 more source

The Effect of Anti\u20103\u2010Hydroxy\u20103\u2010Methylglutaryl\u2010CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice

International audienceABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation.
Zoubairi, Rachid, Martinet, Jeremie, Jaworski, Thara, Drouot, Laurent, Tomasevic, Honorine, Boyer, Olivier, Julien, Sarah   +6 more
core   +1 more source