Results 71 to 80 of about 1,954,791 (139)

Pathogenicity of autoantibodies anti-SRP and anti-HMGCR in autoimmune necrotizing myopathies

, 2017
Les myopathies auto-immunes (MAI), classiquement appelées myosites ou myopathies inflammatoires idiopathiques, représentent un groupe de maladies définies par des caractéristiques cliniques, histopathologiques et biologiques. Une des caractéristiques les
Bergua, Cecile
core  

MOESM1 of Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients

, 2020
Additional file 1 : Table S1.
Baptiste Hervier (7069286), Jean-Paul Makhzoum (8272101), Hélène Couture (8272119), Jean-Luc Senécal (84282), Alain Meyer (2383465), Anne-Marie Mansour (8272089), Jessica Nehme (8272098), Ira Targoff (8272122), Marvin Fritzler (3464078), Marie Hudson (289434), Isabelle Deschênes (845781), Farah Zarka (8272104), Sandra Chartrand (8272095), Catherine Isabelle (287264), Yves Troyanov (84281), Jason Karamchandani (4544797), Sandrine Larue (3433376), Jean-Pierre Raynauld (63745), Sara Hussein (105413), Rami Massie (8272116), Geneviève Oligny-Longpré (8272077), Marianne Landry (8272107), Océane Landon-Cardinal (8272080), Jose Ferreira (6338123), Eric Rich (247418), Edith Villeneuve (4282729), Benjamin Ellezam (8272113), Sabrina Hoa (8272083), Josiane Bourré-Tessier (8272086), Vincent Morin (5736995), Jean-Richard Goulet (8272092), Julie Drouin (8272074), Erin O’Ferrall (8272110), Valérie Leclair (3141204)   +33 more
core   +1 more source

Statin-induced necrotizing autoimmune myopathy: an extremely rare adverse effect from statin use

Journal of Community Hospital Internal Medicine Perspectives, 2019
Statins are widely prescribed medications to prevent cardiovascular events. While self-limited statin myopathy is relatively common, statin-induced necrotizing autoimmune myopathy (SINAM) is extremely uncommon, with incidence of two cases per million per
Priyadarshani Sharma, Bidhya Timilsina, Janak Adhikari, Prem Parajuli, Rashmi Dhital, Niranjan Tachamo   +5 more
doaj   +1 more source

MOESM4 of Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients

, 2020
Additional file 4 : Table S4.
Baptiste Hervier (7069286), Jean-Paul Makhzoum (8272101), Hélène Couture (8272119), Jean-Luc Senécal (84282), Alain Meyer (2383465), Anne-Marie Mansour (8272089), Jessica Nehme (8272098), Ira Targoff (8272122), Marvin Fritzler (3464078), Marie Hudson (289434), Isabelle Deschênes (845781), Farah Zarka (8272104), Sandra Chartrand (8272095), Catherine Isabelle (287264), Yves Troyanov (84281), Jason Karamchandani (4544797), Sandrine Larue (3433376), Jean-Pierre Raynauld (63745), Sara Hussein (105413), Rami Massie (8272116), Geneviève Oligny-Longpré (8272077), Marianne Landry (8272107), Océane Landon-Cardinal (8272080), Jose Ferreira (6338123), Eric Rich (247418), Edith Villeneuve (4282729), Benjamin Ellezam (8272113), Sabrina Hoa (8272083), Josiane Bourré-Tessier (8272086), Vincent Morin (5736995), Jean-Richard Goulet (8272092), Julie Drouin (8272074), Erin O’Ferrall (8272110), Valérie Leclair (3141204)   +33 more
core   +1 more source

PER2 reprograms intracellular cholesterol synthesis to inhibit oral squamous cell carcinoma and the chronotherapeutic efficacy of simvastatin

Cell Death Discovery
Dysregulation of cholesterol homeostasis is closely associated with the development of various cancers, but the underlying mechanisms remain unclear. This study found that the circadian clock gene Period 2 (PER2) is downregulated in oral squamous cell ...
Shilin Yin, Fang Yang, Zhiwei Zhang, Mingyuan Liu, Hong Tang, Kai Yang   +5 more
doaj   +1 more source

The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells

Nature Communications
During cancer immunoediting, cancer cells deregulate cell death executioner mechanisms to escape immunotherapy-induced antitumor immunity. Ferroptosis, a type of regulated necrosis triggered by lipid peroxidation, plays a pivotal role in the anti-tumor ...
Sung Wook Son, Hyo-Jung Lee, NaNa Kang, Seongjae Bae, Eunho Cho, Heeju Kwon, Da-Young Yoon, Chaeleen Lee, Seungho Lee, Min Kyu Son, Jisu Chae, Suyeon Kim, Se Jin Oh, Younji Sim, Kyung-Mi Lee, Cassian Yee, Seon Rang Woo, Yun-Jeong Jeong, Hee-Jung Choi, Jong-Young Kwak, Eun-Woo Lee, Jinuk Park, Sang Gyu Kwak, Young-Chae Chang, Tae Woo Kim, Kwon-Ho Song   +25 more
doaj   +1 more source

Drug repositioning and ovarian cancer, a study based on Mendelian randomisation analysis

Frontiers in Oncology
BackgroundThe role of drug repositioning in the treatment of ovarian cancer has received increasing attention. Although promising results have been achieved, there are also major controversies.MethodsIn this study, we conducted a drug-target Mendelian ...
Lin Zhu, Hairong Zhang, Xiaoyu Zhang, Ruoqing Chen, Lei Xia   +4 more
doaj   +1 more source

Effet des auto-anticorps anti-SRP et anti-HMGCR sur le muscle strié squelettique

, 2016
Immune mediated necrotizing myopathy (IMNM) is recognized as a separate entity among inflammatory myopathies. IMNM is a severe disabling muscle disease requiring prolonged combination of corticosteroid and immunosuppressive drugs. IMNM is morphologically
Arouche-Delaperche, Louiza
core  

MOESM3 of Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients

, 2020
Additional file 3 : Table S3. Chronology of events leading to corticosteroid-free treatment of patients with anti-HMGCR myopathy (N = 14)
Baptiste Hervier (7069286), Jean-Paul Makhzoum (8272101), Hélène Couture (8272119), Jean-Luc Senécal (84282), Alain Meyer (2383465), Anne-Marie Mansour (8272089), Jessica Nehme (8272098), Ira Targoff (8272122), Marvin Fritzler (3464078), Marie Hudson (289434), Isabelle Deschênes (845781), Farah Zarka (8272104), Sandra Chartrand (8272095), Catherine Isabelle (287264), Yves Troyanov (84281), Jason Karamchandani (4544797), Sandrine Larue (3433376), Jean-Pierre Raynauld (63745), Sara Hussein (105413), Rami Massie (8272116), Geneviève Oligny-Longpré (8272077), Marianne Landry (8272107), Océane Landon-Cardinal (8272080), Jose Ferreira (6338123), Eric Rich (247418), Edith Villeneuve (4282729), Benjamin Ellezam (8272113), Sabrina Hoa (8272083), Josiane Bourré-Tessier (8272086), Vincent Morin (5736995), Jean-Richard Goulet (8272092), Julie Drouin (8272074), Erin O’Ferrall (8272110), Valérie Leclair (3141204)   +33 more
core   +1 more source

Taurochenodeoxycholic acid suppresses the progression of glioblastoma via HMGCS1/HMGCR/GPX4 signaling pathway in vitro and in vivo

Cancer Cell International
Glioblastoma multiforme (GBM) is the foremost prevalent and highly aggressive intracranial malignancy, which urgently needs safer and more efficacious therapeutic strategies.
Xiumin Xue, Ziwan He, Furui Liu, Qian Wang, Zhichao Chen, Lin Lin, Danni Chen, Yinfeng Yuan, Zhihui Huang, Yongjie Wang   +9 more
doaj   +1 more source