Results 11 to 20 of about 1,968,036 (106)

Statin-Associated Autoimmune Myopathy: Current Perspectives

Therapeutics and Clinical Risk Management, 2020
Eleni Tiniakou Johns Hopkins University School of Medicine, Department of Medicine, Division of Rheumatology, Baltimore, MD, USACorrespondence: Eleni TiniakouJohns Hopkins University School of Medicine, 5200 Eastern Avenue, Mason Lord, Center Tower ...
Tiniakou E
doaj   +1 more source

Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy

BMC Immunology
Background Immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy (IIM). Though patients with IMNM were not considered to show skin rash, several reports have showed atypical skin conditions in patients with anti-3-hydroxy-3 ...
Takashi Kurashige, Rie Nakamura, Tomomi Murao, Naoko Mine, Mayu Sato, Riho Katsumata, Yuhei Kanaya, Yoriko Dodo, Tomohito Sugiura, Tomohiko Ohshita   +9 more
doaj   +2 more sources

A Case Report of Anti–3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy

Annals of Internal Medicine: Clinical Cases
We present a 75-year-old woman with 3 months of progressive proximal muscle weakness, myalgias, and dysphagia. Her admission was complicated by acute hypoxic respiratory failure requiring admission to the intensive care unit.
Monique Crawford, Xiaoshan Gong, Johnny M. Trinh, Sachin Chaudhary   +3 more
doaj   +2 more sources

Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy: An unusual presentation

Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy is adistinct necrotising autoimmune myopathy associated with statin use. This does notimprove after discontinuation of the statin and usually has a progressive course that requires ...
Rashid, Amjid, Chinoy, Hector; id_orcid, Wig, Surabhi, Filer, Charlotte   +3 more
core   +11 more sources

Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies

Acta Médica Portuguesa, 2022
Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR ...
Cláudia Fidalgo, Alice Mendes, Rosário Cunha, Fernando Rodrigues   +3 more
doaj   +1 more source

Case report: Diagnostic clues for anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase myopathy in pediatric patients

Frontiers in Pediatrics, 2023
IntroductionAnti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy is a recently recognized pathology, but appears less common in children and the characteristics of pediatric cases remain unclear.Case reportWe report a pediatric case of ...
Keisuke Watanuki, Hiroshi Koga
doaj   +1 more source

Statins and muscle – friends or foes? Discussions based on a case report [PDF]

Romanian Journal of Rheumatology, 2022
Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by relatively severe proximal weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy, and infrequent extra-muscular involvement ...
Andra Patricia Stanciu, Cristina Nita, Laura Groseanu   +2 more
doaj   +1 more source

Autoimmune anti-HMGCR myopathy: a rare but disabling complication of statin therapy

, 2022
Presentation  An 85-year-old farmer developed disabling progressive proximal limb weakness and dysphagia after 10 years of statin therapy.  Diagnosis  Creatine kinase was elevated, and electromyography demonstrated myopathic abnormalities.
Patrick Moloney (7948142), Y Banaga (14001949), J Cryan (12709166), K O'Rourke (13685812), T Lynch (14001952), I O’Dea (13992867), J Corrigan (13396956)   +6 more
core   +3 more sources

Anti-HMGCR myopathy: barriers to prompt recognition [PDF]

, 2022
Anti-HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) myopathy is an immune-mediated necrotising myopathy. Atypical presentations hinder its recognition and its prompt treatment.
Barp, Andrea, Hanna, Michael G, Merve, Ashirwad, Bugiardini, Enrico, Shah, Sachit, Desikan, Mahalekshmi   +5 more
core   +1 more source

Initial seronegative immune-mediated necrotising myopathy with subsequent anti-HMGCR antibody development and response to rituximab: case report

BMC Rheumatology, 2020
Background Immune-mediated necrotising myopathy (IMNM) is characterised by severe muscle weakness and necrosis with a paucity of inflammation on muscle biopsy. Around 60% of cases are associated with antibodies to the signal recognition particle (SRP) or
Rhys Thomas, Su-Ann Yeoh, Rupert Berkeley, Andrew Woods, Mike Stevens, Silvia Marino, Aleksandar Radunovic   +6 more
doaj   +1 more source