Results 31 to 40 of about 1,968,036 (106)

Statin-associated muscle disorders

Indian Journal of Rheumatology, 2020
Statins are one of the most widely used and reputable medications worldwide, with strong evidence of mitigating cardiovascular complications and with a generally favorable safety profile.
Alan Xu, Vidya Limaye
doaj   +1 more source

Expert Perspective: Toward Treat‐to‐Target Management in Adult Idiopathic Inflammatory Myopathies

Arthritis &Rheumatology, Accepted Article.
Treat‐to‐target (T2T) has transformed the management of several rheumatic diseases through predefined therapeutic goals, structured disease assessment, and timely treatment adjustment. Despite major advances in the understanding and treatment of idiopathic inflammatory myopathies (IIM), a formal T2T framework for adult IIM has not yet been established.
Shiri Keret, Nantakarn Pongtarakulpanit, Rohit Aggarwal   +2 more
wiley   +1 more source

Perivascular and endomysial macrophages expressing VEGF and CXCL12 promote angiogenesis in anti-HMGCR immune-mediated necrotizing myopathy [PDF]

, 2022
Objectives: To study the phenotype of macrophage infiltrates and their role in angiogenesis in different idiopathic inflammatory myopathies (IIMs). Methods: The density and distribution of the subpopulations of macrophages subsets (M1, inducible nitric ...
Fornaro, Marco, Iannone, Florenzo, Annese, Tiziana, Errede, Mariella, Giannini, Margherita, Girolamo, Francesco, Virgintino, Daniela, D'Abbicco, Dario, Lorusso, Loredana, Amati, Angela, Trojano, Maria, Ribatti, Domenico, Tampoia, Marilina, Lia, Anna, Serlenga, Luigi   +14 more
core   +1 more source

Glycoproteomic Signatures of IgG Subclass N‐Glycosylation Reveal Molecular Endotypes in Idiopathic Inflammatory Myopathies

MedComm, Volume 7, Issue 10, October 2026.
• EThcD‐sceHCD‐MS/MS and updated PANDA software decode IgG N‐glycosylation in IIMs. • Unsupervised clustering reveals three novel glyco‐endotypes matching clinical phenotypes. • A seven‐glycopeptide model enables robust endotype prediction beyond conventional subtypes.
Tong Wu, Yanhong Li, Yingying Ling, Yinlan Wu, Jing Zhao, Lu Cheng, Chunyu Tan, Yi Zhang, Yong Zhang, Yi Liu   +9 more
wiley   +1 more source

Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy

European Journal of Case Reports in Internal Medicine, 2021
We report a case of anti-HMGCR myopathy mimicking limb-girdle muscular dystrophy in a 27-year-old male patient with no history of statin intake and presenting with a chronic onset form over 3 years.
Noel Lorenzo Villalba, Emmanuel Andrés, Alain Meyer   +2 more
doaj   +1 more source

Dysregulation of Peripheral Blood B Cells and Natural Killer Cells Is Associated With Myocarditis in Idiopathic Inflammatory Myopathies

ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
Objective Idiopathic inflammatory myopathies (IIMs), or myositis, are a group of systemic autoimmune diseases leading to proximal muscle weakness. Myocarditis is a major cause of adverse outcomes. Yet, we know very little about the underlying immunologic processes that are driving myocarditis in the context of IIMs. Methods We performed single‐cell RNA
Carolina Duque, Sylvie T. Rousseau, Zuzana Bologna, Monica R. Mugnier, Luigi Adamo, Julie J. Paik   +5 more
wiley   +1 more source

Immunotherapy reversed myopathy but not cardiomyopathy in a necrotizing autoimmune myopathy patient with positive anti-SRP and MDA-5 autoantibodies

BMC Cardiovascular Disorders, 2021
Background Necrotizing autoimmune myopathy (NAM) is pathologically characterized by myofiber necrosis and regeneration with paucity or absence of inflammatory cells in muscle biopsy.
Xue Ma, Li Xu, Yue Li, Bitao Bu
doaj   +1 more source

Seronegative Granulomatous Myositis With Bulbar Weakness and Reversible Cardiomyopathy: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT A 64‐year‐old woman presented with seronegative idiopathic granulomatous myositis, featuring severe bulbar weakness, reversible cardiomyopathy (ejection fraction 20%–25%), hepatic injury, and acute kidney injury. Muscle biopsy confirmed granulomatous inflammation.
Balachandran R. Vaidyanathan, Muhamed Abubacker, John Ponugupati   +2 more
wiley   +1 more source

Dengue infection triggered immune mediated necrotizing myopathy in children: a case report and literature review

Pediatric Rheumatology Online Journal, 2022
Background Immune-mediated necrotizing myopathy (IMNM) is a subgroup of idiopathic inflammatory myopathies manifesting with progressive weakness, elevated serum creatine kinase (CK) levels, and necrotizing myopathic features on muscle biopsy.
Aphirak Mekmangkonthong, Jakkrit Amornvit, Numphung Numkarunarunrote, Montida Veeravigrom, Parichat Khaosut   +4 more
doaj   +1 more source

Paraneoplastic Myopathy as a Possible Initial Presentation of Sporadic Burkitt Lymphoma in an Immunocompetent Adult: A Case Report

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Burkitt's lymphoma (BL) is a highly aggressive B‐cell non‐Hodgkin lymphoma with rapid proliferation and early systemic dissemination. Neuromuscular manifestations are rare and are typically secondary to direct infiltration or metabolic complications.
Abolfazl Khalafi‐Nezhad, Dena Firouzabadi, Vahid mohammadkarimi, Amirreza Dehghanian   +3 more
wiley   +1 more source