Results 51 to 60 of about 1,968,036 (106)

Etiopathogenesis of Immune‐Mediated Necrotizing Myopathy: A Comprehensive Review of Recent Advances

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
This review systematically clarifies that the core of IMNM begins with specific autoantibodies, which in turn trigger complement activation, immune cell infiltration, and a storm of inflammatory factors. Together, these processes induce regulatory cell death and mitochondrial dysfunction, ultimately leading to muscle fiber necrosis. Genetic factors and
Chang Gao, Wenli Li, Qingyan Liu, Guochun Wang, Qinglin Peng   +4 more
wiley   +1 more source

Risk Factors for Recurrence of the Anti‐Synthetase Syndrome Related Interstitial Lung Disease

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Purpose This current study aimed to detect the risk factors for recurrence of the anti‐synthetase syndrome related interstitial lung disease (ASSD‐ILD). Methods Patients who were diagnosed with ASSD‐ILD and achieved the improving standards after treatment at a single clinical center from January 1, 2017 to January 1, 2022 were retrospectively ...
Zhen‐Yu Ren, Xue Yang, Jing Yang, Ping Kou, Xiao‐Kui Tang   +4 more
wiley   +1 more source

MOESM1 of Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients

, 2020
Additional file 1 : Table S1.
Baptiste Hervier (7069286), Jean-Paul Makhzoum (8272101), Hélène Couture (8272119), Jean-Luc Senécal (84282), Alain Meyer (2383465), Anne-Marie Mansour (8272089), Jessica Nehme (8272098), Ira Targoff (8272122), Marvin Fritzler (3464078), Marie Hudson (289434), Isabelle Deschênes (845781), Farah Zarka (8272104), Sandra Chartrand (8272095), Catherine Isabelle (287264), Yves Troyanov (84281), Jason Karamchandani (4544797), Sandrine Larue (3433376), Jean-Pierre Raynauld (63745), Sara Hussein (105413), Rami Massie (8272116), Geneviève Oligny-Longpré (8272077), Marianne Landry (8272107), Océane Landon-Cardinal (8272080), Jose Ferreira (6338123), Eric Rich (247418), Edith Villeneuve (4282729), Benjamin Ellezam (8272113), Sabrina Hoa (8272083), Josiane Bourré-Tessier (8272086), Vincent Morin (5736995), Jean-Richard Goulet (8272092), Julie Drouin (8272074), Erin O’Ferrall (8272110), Valérie Leclair (3141204)   +33 more
core   +1 more source

Myasthenia gravis following the initiation of statin therapy: A multinational self‐controlled case series study

Journal of Internal Medicine, Volume 299, Issue 4, Page 502-514, April 2026.
Abstract Background Evidence regarding the risk of new‐onset myasthenia gravis (MG) following statin therapy initiation is limited. Objectives To investigate this potential adverse effect using multinational real‐world population‐based data. Methods A self‐controlled case series (SCCS) study was conducted using electronic medical records and claims ...
Vincent Ka Chun Yan, Wanchun Xu, Yuta Taniguchi, Kwun Kei Fung, Koon Ho Chan, Gary Kui Kai Lau, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Masao Iwagami, Rie Masuda, Nanako Tamiya, Sreemanee Raaj Dorajoo, Jing Wei Neo, Esther Wai Yin Chan, Ian Chi Kei Wong, Eric Yuk Fai Wan   +16 more
wiley   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Six Years Follow-Up of an 11-Year-Old Girl with Anti-HMGCR Myopathy

. Anti-HMGCR myopathy is decribed as an immune-mediated necrotizing myopathy which is characterised by subacute, progressive proximal muscle weakness and elevated creatine kinase (CK) level.
Cavusoglu, Dilek, Ekinci, Gazanfer, Topaloglu, Haluk, TALİM, BERİL   +3 more
core   +1 more source

Laboratory tests and clinical significance of anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibody

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibody is a newly recognized autoantibody, which is associated with the use of statins and is considered as an immunological marker of necrotizing autoimmune myopathy (NAM).
Jing-jing LUO, Feng GAO, Jie-xi WEN, Hong-jun HAO, Jing GUO, Yi-ning HUANG   +5 more
doaj  

Anti-HMGCR antibodies and asymptomatic hyperCKemia. A case report

, 2021
Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) related myositis is a form of immune-mediated necrotizing myopathy (IMNM). Anti-HMGCR autoantibodies target HMGCR, a glycoprotein linked to the endoplasmic reticulum implied in the cholesterol ...
Ali G., Ricci G., Chico L., Siciliano G., Torri F.   +4 more
core   +1 more source

Association of anti-HMGCR antibodies of the IgM isotype with refractory immune-mediated necrotizing myopathy

Arthritis Research & Therapy
Objective Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies are one of the myositis-specific antibodies which is associated with immune-mediated necrotizing myopathy (IMNM).
Hongxia Yang, Chao Sun, Lifang Ye, Yuetong Xu, Sang Lin, Qinglin Peng, Guochun Wang, Xin Lu   +7 more
doaj   +1 more source

MOESM4 of Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients

, 2020
Additional file 4 : Table S4.
Baptiste Hervier (7069286), Jean-Paul Makhzoum (8272101), Hélène Couture (8272119), Jean-Luc Senécal (84282), Alain Meyer (2383465), Anne-Marie Mansour (8272089), Jessica Nehme (8272098), Ira Targoff (8272122), Marvin Fritzler (3464078), Marie Hudson (289434), Isabelle Deschênes (845781), Farah Zarka (8272104), Sandra Chartrand (8272095), Catherine Isabelle (287264), Yves Troyanov (84281), Jason Karamchandani (4544797), Sandrine Larue (3433376), Jean-Pierre Raynauld (63745), Sara Hussein (105413), Rami Massie (8272116), Geneviève Oligny-Longpré (8272077), Marianne Landry (8272107), Océane Landon-Cardinal (8272080), Jose Ferreira (6338123), Eric Rich (247418), Edith Villeneuve (4282729), Benjamin Ellezam (8272113), Sabrina Hoa (8272083), Josiane Bourré-Tessier (8272086), Vincent Morin (5736995), Jean-Richard Goulet (8272092), Julie Drouin (8272074), Erin O’Ferrall (8272110), Valérie Leclair (3141204)   +33 more
core   +1 more source