Results 71 to 80 of about 1,968,036 (106)

Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins

Rheumato
Statins are effective drugs for lowering cholesterol and reducing cardiovascular risk. Rarely, they can trigger autoimmune myopathies like immune-mediated necrotizing myopathy (IMNM), associated with anti-HMGCR antibodies.
Luis Angel Montero Furelos, Clara Fernandez Peña, Beatriz San Millan Tejedor   +2 more
doaj   +1 more source

Treatment of refractory immune-mediated necrotizing myopathy with efgartigimod

Frontiers in Immunology
ObjectiveWe aimed to explore the efficacy and safety of efgartigimod in patients with refractory immune-mediated necrotizing myopathy (IMNM).MethodsThis open-label pilot observational study included seven patients with refractory IMNM, all of whom ...
MengTing Yang, JingChu Yuan, YiKang Wang, HongJun Hao, HongJun Hao, Wei Zhang, Wei Zhang, ZhaoXia Wang, ZhaoXia Wang, Yun Yuan, Yun Yuan, YaWen Zhao   +11 more
doaj   +1 more source

Statin-Associated Muscle Symptoms and Myotoxicity: A Clinically Oriented Narrative Review with a Practical Prevention, Evaluation, and Management Algorithm

Medicina
Background and Objectives: Muscle symptoms are the most visible adverse event attributed to statins, but terminology is often imprecise. Most patients report myalgia or nonspecific aches, whereas objective myopathy, inflammatory or necrotizing myositis ...
Francisco Epelde
doaj   +1 more source

Miositis necrosante autoinmune asociada al uso de atorvastatina: reporte de un caso y revisión de la literatura

Medicina Clínica Práctica
Resumen: La miositis necrosante autoinmune (MNA) asociada al uso de estatinas es una entidad poco frecuente, caracterizada por debilidad muscular proximal progresiva, elevación marcada y persistente de la creatinfosfoquinasa y presencia de ...
Luis Ángel Rodríguez-Chávez, Melissa Ysabel Romero-Díaz, Christian Alberto Vargas Machuca-Carranza, José Guillermo Cabanillas-López   +3 more
doaj   +1 more source

Statin-induced autoimmune necrotizing myositis

Rheumatology, 2016
Myositides comprise a large group of disorders involving limb muscle weakness. In differential diagnosis we have to consider idiopathic myositides, myositides associated with other diseases, and those induced by external factors, e.g.
Katarzyna Ząber, Beata Śliwowska, Tomasz Jasiński   +2 more
doaj   +1 more source

Autoimmune necrotising myopathy and HMGCR antibodies

, 2018
Statins lower serum cholesterol concentrations by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). Muscle side effects are relatively common and include asymptomatic elevation of serum creatine kinase (CK), myalgia, proximal
Monika Hofer, Dimitri Amiras, Stuart Viegas, Kushan Karunaratne, Matthew C Pickering   +4 more
core   +1 more source

Immunopathogenesis of Immune-Mediated Necrotizing Myopathy: Insights Drawn from Pathological Phenotypes and Mechanistic Elaboration

Biomedicines
Immune-mediated necrotizing myopathy (IMNM) is a distinct subtype of idiopathic inflammatory myopathies (IIMs), classified by serum autoantibody status into anti-signal recognition particle (anti-SRP)-positive, anti-3-hydroxy-3-methylglutaryl-coenzyme A ...
Xiaoke Wu, Junjie Qian, Xin Wang, Na Ji, Yingning Li, Shuying Chen, Qingjie Li, Meirong Liu, Qi Fang   +8 more
doaj   +1 more source

Immune-Mediated Necrotizing Myopathy (IMNM): A Story of Antibodies

Antibodies
Immune-mediated necrotizing myopathy (IMNM) is a rare and severe disease that corresponds to a specific entity of idiopathic inflammatory myopathy. Patients with IMNM suffer from proximal muscle weakness, and present high levels of creatine kinase and ...
Sarah Julien, Inès Challier, Marine Malleter, Fabienne Jouen, Laurent Drouot, Olivier Boyer   +5 more
doaj   +1 more source

The incidence of anti-HMGCR immune-mediated necrotising myopathy: an Australian and UK retrospective multi-site cohort study [PDF]

Objectives: Immune-mediated necrotising myopathy (IMNM) with autoantibodies targeting 3-hydroxy-3-methylglutaryl-CoA reductase (anti-HMGCR) is considered a rare complication of statin therapy.
Brusch, Anna, Needham, Merrilee, Chinoy, Hector; id_orcid, Buch, Maya H, Limaye, Vidya, Khoo, Thomas, Lilleker, James B, Lilleker, James; id_orcid, Lamb, Janine; id_orcid, Gunawardena, Harsha, Tomaszewski, Maciej, Tan, Elina, Bahadori, Aaron, Buch, Maya; id_orcid, Tomaszewski, Maciej; id_orcid, Lamb, Janine A, Chinoy, Hector, Austin, Keziah, Lyu, Xia, Sadler, Ross   +19 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source