Results 21 to 30 of about 1,968,036 (106)

Case Report: Immune Mediated Necrotizing Myopathy With IgG Antibodies to 3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase (HMGCR) May Present With Acute Systolic Heart Failure

Frontiers in Neurology, 2020
Involvement of cardiac muscle is felt to be very uncommon in anti-HMGCR myopathy, and therefore early cardiac evaluation is not considered a high priority for this condition.
Malik Ghannam, Georgios Manousakis
doaj   +1 more source

Screening for Anti-HMGCR Antibodies in a Large Single Myositis Center Reveals Infrequent Exposure to Statins and Diversiform Presentation of the Disease

Frontiers in Immunology, 2022
BackgroundThe objective of this study is to assess the frequency of autoantibodies against 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) in a single center myositis cohort and to analyze associations with statin exposure, clinical features ...
Piotr Szczesny, Simone Barsotti, Simone Barsotti, Inger Nennesmo, Olof Danielsson, Maryam Dastmalchi, Maryam Dastmalchi, Maryam Dastmalchi   +7 more
doaj   +1 more source

Phenotype standardization for statin-induced myotoxicity. [PDF]

, 2014
Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis.
Fahy, J., Neely, D, Fahy, J, Wadelius, M, Palmer, CN, Carr, D. F., Maitland-van Der Zee, AH, Laaksonen, R, Maitland-van Der Zee, A. H., Wadelius, M., Yue, QY, Chinoy, H.; id_orcid, Psaty, BM, Bloch, K. M., Cooper, R. G., Neely, D., Psaty, B. M., Chinoy, H., Pirmohamed, M., Chinoy, H, Palmer, C. N. A., Voora, D, Palmer, C. N. A.; id_orcid, Voora, D., Armitage, J., Wadelius, Mia,, Yue, Q. Y., Alfirevic, A., Alfirevic, A, Armitage, J, Palmer, C. N A, Pirmohamed, M, Palmer, PN, Hanson, A., Bloch, KM, Laaksonen, R., Cooper, RG, Yue, Q-Y, Wadelius, Mia, Carr, DF, Hanson, A   +40 more
core   +1 more source

Anti-HMGCR Immune-Mediated Necrotising Myopathy: Addressing the Remaining Issues

, 2023
The discovery of autoantibodies directed against the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) enzyme has defined a sub-set of immune-mediated necrotising myopathy (IMNM) which is strongly associated with exposure to statin medications.
Chinoy, Hector; id_orcid, Khoo, Thomas
core   +1 more source

A Case of Refractory Myositis

Journal of Clinical Rheumatology and Immunology, 2019
We report here a statin naive lady who had refractory myositis for years. The diagnosis was revised to be anti-HMGCR related immune mediated necrotizing myopathy after repeating the muscle biopsy and checking the autoantibody.
Lucas Luk, Ho So
doaj   +1 more source

A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges

Case Reports in Rheumatology, 2022
Statin-induced necrotizing autoimmune myopathy is an immune-mediated necrotizing myopathy related to the use of statins. It is a very rare disease, which usually presents with proximal muscle weakness and frank elevation in creatine kinase levels ...
Anwar I. Joudeh, Mhd Kutaiba Albuni, Sara Seife Hassen, Phool Iqbal, Elsaid Mohamed Aziz Bedair, Salah Mahdi   +5 more
doaj   +1 more source

Treatment experience of Taiwanese patients with anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase myopathy

Kaohsiung Journal of Medical Sciences, 2020
Immune‐mediated necrotizing myopathy (IMNM) has emerged as a new subgroup of idiopathic inflammatory myopathy in the past decade, associated with the presence of two autoantibodies against signal recognition particle and 3‐hydroxy‐3‐methylglutaryl ...
Wen‐Chen Liang, Chen‐Hua Wang, Wan‐Zi Chen, Yun‐Ting Kuo, Hsiu‐Fen Lin, Shigeaki Suzuki, Ichizo Nishino, Yuh‐Jyh Jong   +7 more
doaj   +1 more source

Anti-HMGCR myopathy may resemble limb-girdle muscular dystrophy

, 2018
International audienceObjective To determine the prevalence and clinical features of anti-HMGCR myopathy among patients with presumed limb-girdle muscular dystrophy (LGMD) in whom genetic testing has failed to elucidate causative mutations.
Fequiere, Pierre, Béhin, Anthony, Stojkovic, Tanya, Bönnemann, Carsten, Bönnemann, Carsten G, Toro, Camilo, Harper, Amy, Drachman, Daniel, Shebert, Robert T, Lafôret, Pascal, Pak, Katherine S, Foley, A Reghan, Mohassel, Payam, Wahl, Colleen, Eymard, Bruno, Mammen, Andrew L, Mammen, Andrew, Benveniste, Olivier, Pak, Katherine, Donkervoort, Sandra, Foley, A. Reghan, Meriggioli, Matthew, Landon-Cardinal, Océane, Allenbach, Yves, Shebert, Robert   +24 more
core   +1 more source

Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies

Journal of Immunology Research, 2014
Diagnostic tests are needed to aid in the diagnosis of necrotizing myopathies associated with statin use. This study aimed to compare different technologies for the detection of anti-HMGCR antibodies and analyze the clinical phenotype and autoantibody ...
Lucile Musset, Makoto Miyara, Olivier Benveniste, Jean-Luc Charuel, Alexander Shikhman, Olivier Boyer, Richard Fowler, Andrew Mammen, Joe Phillips, Michael Mahler   +9 more
doaj   +1 more source

Deep venous thrombosis in an individual with statin-exposed anti-SRP myopathy: case report and review of literature

Thrombosis Journal, 2021
Background Immune-mediated necrotizing myopathy (IMNM) is characterized by proximal muscle weakness, elvated serum muscle enzyme levels, myopathic electromyography findings, and necrotic muscle fiber with few inflammatory cell infiltration in muscle ...
Jiali Li, Mingming Yan, Jiao Qin, Lingyan He, Cao Dai, Rui Wen   +5 more
doaj   +1 more source