Results 91 to 100 of about 2,131,769 (283)

Human digital Meissner's corpuscles are not doubly innervated

The Anatomical Record, EarlyView.
Abstract Recent studies have shown that murine and avian Meissner‐like corpuscles are innervated by two distinct mechanoreceptor afferents with different functional properties. In addition, there is evidence that one subpopulation of Meissner corpuscles of monkeys is doubly innervated by mechanoreceptors and nociceptors.
Patricia Cuendias, Yolanda García‐Mesa, Iván Suazo, Marta Alonso‐Guervós, Jorge García‐Piqueras, Ana M. Abreu‐Velez, Olivia García‐Suárez, Jorge Feito, José A. Vega   +8 more
wiley   +1 more source

Anti-nociceptive and antipyretic activities of Solanum violaceum ortega

, 2017
Solanum violaceum Ortega has been used by the traditional medicine practitioners in pain and fever. This study aimed at investigating anti-nociceptive and antipyretic activities of methanol extract of leaf (MELSV), fruit (MEFSV) and root (MERSV) of S ...
Syed Tareq, Baharul Islam, Afroz Karim, Muhammad Islam   +3 more
core   +1 more source

Early Synovial Regulatory T Cell Engagement in Posttraumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early postinjury biologic processes within the synovium shape disease trajectories. We investigated whether synovial Treg cells are engaged during the early phase following joint injury and whether experimental enrichment of this ...
Xueyou Zhang, Mingde Cao, Jianting Li, Bruma Sai‐Chuen Fu, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung   +5 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund's adjuvant (CFA)-induced arthritis in rats

Integrative Medicine Research, 2018
Background: The medicinal uses of plants are in many cases based exclusively on traditional knowledge without enough scientific evidences. Different parts of Moringa oleifera were traditionally used for the treatment of wide variety of ailments including
Harith Jameel Mahdi, Nurzalina Abdul Karim Khan, Mohd Zaini Bin Asmawi, Roziahanim Mahmud, Vikneswaran A/L Murugaiyah   +4 more
doaj   +1 more source

Unveiling Pharmacological Responses and Potential Targets Insights of Identified Bioactive Constituents of Cuscuta reflexa Roxb. Leaves through In Vivo and In Silico Approaches

Pharmaceuticals, 2020
Cuscuta reflexa Roxb. is traditionally used by the indigenous communities of Bangladesh to treat different diseases, such as pain, edema, tumor, jaundice, and skin infections.
Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kamal, Md. Riad Chowdhury, Md. Shariful Islam, Md. Amzad Hossain, Abu Montakim Tareq, Md. Imam Hossain Bhuiyan, Md Nasim Uddin, Afroza Tahamina, Md Obyedul Kalam Azad, Young Seok Lim, Dong Ha Cho   +12 more
doaj   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Evaluation of Anti-Nociceptive and Analgesic Activities of Nizatidine in Mice [PDF]

, 2020
Previous research reports revealed that histamine H2 receptor blockers such as ranitidine and famotidine showed analgesic activity in rodent models. However, the analgesic or anti-nociceptive activity of nizatidine, a most widely used H2 receptor blocker,
Kanagaraj, M
core  

PRDM16 is necessary for sensory neuronal development and differentiation in the trigeminal ganglion

Developmental Dynamics, EarlyView.
Abstract Background Cranial neural crest cells (cNCC) generate craniofacial cartilage, bone, and peripheral neurons and glia, and birth defects arise when the cartilage/neuronal/glial progenitors fail to differentiate. PRDM16 is a transcriptional regulator containing both zinc‐finger and SET domains, implicated in craniofacial development and orofacial
Fahmida Raha, Qiman Gao, Lomeli C. Shull, Kristin B. Artinger   +3 more
wiley   +1 more source

Anti-inflammatory and anti-nociceptive activities of methanolic leaf extract of Indigofera cassioides Rottl. Ex. DC.

, 2013
ObjectiveTo evaluate the anti-inflammatory and analgesic activities of methanolic leaf extract of Indigofera cassioides (I. cassioides) (MEIC) using various animal models.MethodsAnti-inflammatory and analgesic activities of MEIC was assessed by using ...
Raju Senthil Kumar, Balasubramanian Rajkapoor, Perumal Perumal   +2 more
core   +1 more source