Results 71 to 80 of about 2,131,769 (283)
Scientific Reports, 2022 Various fatty acyl lipid mediators are derived from dietary polyunsaturated fatty acids (PUFAs) and modulate nociception. The modern diet is rich in linoleic acid, which is associated with nociceptive hypersensitivities and may present a risk factor for ...
Nada Birkic +4 more
doaj +1 more source
Glutamate Transporter Activators as Anti-Nociceptive Agents
The Eurasian Journal of Medicine, 2019 Abstract The effective management of chronic pain remains enigmatic. There is a paucity of effective mechanistically-based approaches employed. Chronic visceral pain is a particularly difficult subcategory to manage. Glutamate is the most predominant excitatory neurotransmitter and mediates many aspects of sensory function including acute and chronic ...
openaire +3 more sources
Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
wiley +1 more source
Evaluation of anti-nociceptive and anti-inflammatory activities of hydroalcoholic extract derived from root of Apium graveolens L. in mice [PDF]
Research Journal of Pharmacognosy, 2017 Background and objectives: Apium graveolens L. (celery) has been considered as sedative, analgesic, carminative, antispasmodic and diuretic plant in traditional Iranian medicine.
doaj
Effects of Peptidase Inhibitors on the Enkephalin-Induced Anti-nociception in Rats
Japanese Journal of Pharmacology, 1998 The intra-third-ventricular (i.t.v.) administration of [Met5]-enkephalin (enk) to rats pretreated i.t.v. with three peptidase inhibitors (PIs), amastatin, captopril and phosphoramidon, inhibited the tail-flick response. The enk-induced inhibition was augmented by increasing the doses of the three PIs, with the maximum inhibition being attained at the ...
Taniguchi, Takao +3 more
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Advanced Science, EarlyView.Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou +15 more
wiley +1 more source
Molecular Pain, 2012 Background Ethyl pyruvate (EP) possesses anti-inflammatory activity. However, the potential anti-nociceptive value of EP for the treatment of the inflammatory nociception is largely unknown.
Lee Min +4 more
doaj +1 more source
Advanced Science, EarlyView.RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He +12 more
wiley +1 more source
Clinical Evaluation of Analgesic Activity of Guduchi (Tinospora Cordifolia) Using Animal Model [PDF]
Journal of Clinical and Diagnostic Research, 2014 Introduction: Pain is a very well-known signal of ill health and analgesics are the drugs that are used to relieve pain. The main problem with these drugs remains that of side effects. Safer alternatives are natural herbs.
Bhomik Goel +5 more
doaj +1 more source
Anti-nociceptive mechanisms of electroacupuncture in inflammatory pain
AME Medical Journal, 2017 Acupuncture and electroacupuncture (EA) are widely applied as non-invasive treatment for acute and chronic pain. In the last decade, mechanisms of EA analgesia in inflammatory pain have been extensively studied (1-4).
Qing-Ying Liu, Ling-Chi Xu, Ming Yi
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