Results 61 to 70 of about 2,131,769 (283)

Evaluation of anti-inflammatory, anti-nociceptive, and anti-pyretic potential of hydroalcoholic extract of Trifolium pratense in mice

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2019
Introduction: There are some reports in traditional medicine concerning the anti-inflammatory, anti-nociceptive and anti-pyretic effects of Trifolium pretense (red clover).
Parandin R
doaj  

Anti-nociceptive and Anti-inflammatory Activities of Wrightia arborea

Pakistan Journal of Biological Sciences, 2013
Anti-nociceptive and anti-inflammatory effects of methanolic extract of Wrightia arborea (MEWA) were examined using different models in rats. MEWA was given to rats orally upto 2000 mg kg(-1) b.wt. for acute toxicity study and observed for 14 days. Anti-nociceptive activity was evaluated in rats against Acetic acid induced writhing (chemically induced ...
Laizuman, Nahar, Fatema, Nasrin, Ronok, Zahan, Md Ashik, Mosaddik   +3 more
openaire   +2 more sources

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Synthesis and anti-nociceptive potential of isoxazole carboxamide derivatives

BMC Chemistry, 2019
Isoxazole is an important pharmacophore in medicinal chemistry with a wide range of pharmacological activities. The present study deals with the synthesis and evaluation of antinociceptive potential of nine novel 3-substituted-isoxazole-4-carboxamide derivatives.In the first step, respective oxime was prepared and further treated with ethylacetoacetate
Hajira Bibi, Humaira Nadeem, Muzaffar Abbas, Muazzam Arif   +3 more
openaire   +3 more sources

A mechanistic approach to anti-nociceptive potential of Artemisia macrocephala Jacquem [PDF]

BMC Complementary and Alternative Medicine, 2016
Artemisia macrocephala Jacquem (A. macrocephala)، المعروف محليًا باسم "Tarkha"، هو نبات معمر يوجد بكثرة في المناطق الشمالية من باكستان. يستخدم على نطاق واسع في الطب التقليدي لعلاج الحمى والألم واضطرابات الجهاز الهضمي والسكري. حتى الآن، لا توجد دراسات منشورة متاحة فيما يتعلق بالإمكانات المضادة للمستقبلات في الجسم الحي للمستخلص الخام والكسور الفرعية من ...
Muhammad Harris Shoaib, Ismail Shah, Niaz Ali, Wadood Ali Shah   +3 more
openaire   +2 more sources

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

In-vitro antioxidant activities, anti-nociceptive and neuropharmacological activities of Polygonum hydropiper [PDF]

, 2013
In the present study in-vitro antioxidant activities, anti-nociceptive assessment and neuropharmacological study of the leaf extract of Polygonum hydropiper was performed. In-vitro antioxidant activity of the extracts of P. hydropiper was performed using
Bhuiyan, Mohiuddin Ahmed, Haque, Md. Aminul, Chowdhury, Zahid Sadek, Sharif, Shahjabeen, Islam, Md. Reazul, Shahriar, Mohammad   +5 more
core   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source