Results 81 to 90 of about 2,131,769 (283)

Anti‐nociceptive responses produced by human putative counterpart of nocistatin [PDF]

British Journal of Pharmacology, 1998
b‐nocistatin is a heptadecapeptide produced from bovine prepronociceptin and blocks the induction of hyperalgesia and touch‐evoked pain (allodynia) by intrathecal administration of nociceptin or prostaglandin E2 (PGE2). Human prepronociceptin may generate a 30‐amino acid peptide different in length from b‐nocistatin.
Minami, T., Okuda-Ashitaka, E., Nishiuchi, Y., Kimura, T., Tachibana, S., Mori, H., Ito, S.   +6 more
openaire   +2 more sources

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Synergistic Antinociceptive Effect of β-Caryophyllene Oxide in Combination with Paracetamol, and the Corresponding Gastroprotective Activity

Biomedicines
Pain is the most frequent symptom of disease. In treating pain, a lower incidence of adverse effects is found for paracetamol versus other non-steroidal anti-inflammatory drugs.
Josué Vidal Espinosa-Juárez, Jesús Arrieta, Alfredo Briones-Aranda, Leticia Cruz-Antonio, Yaraset López-Lorenzo, María Elena Sánchez-Mendoza   +5 more
doaj   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Contribution of nociceptin/orphanin FQ receptors to the anti-nociceptive and hypothermic effects of dipyrone

, 2015
Background Dipyrone is one of the most commonly used non-opioid analgesic and antipyretic drug. Its anti-nociceptive and hypothermic effects have long been suspected to be centrally mediated. The involvement of the most recently discovered opioid peptide,
Ulugol, Ahmet, Ertin, Ismet Hande, Gunduz, Ozgur   +2 more
core   +1 more source

Novel Aryl/Alkyl Azole Derivates as an anti-nociceptive and anti-inflammatory drug candidates [PDF]

, 2020
Novel aryl/alkyl azole derivative compounds C1 and C2 were screened for in vivo anti-nociceptive and anti-inflammatory activities by using the hot plate test and formalin-induced hind paw edema test, respectively.
Barut, Elif N., Dogan, Inci S., Kaya-Yasar, Yesim, Engin, Seckin, Sezen, Feride S., Sezen, Sena F., Dogan, İNCİ SELİN, BARUT, ELİF NUR   +7 more
core   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source

Anti-nociceptive effect of vitexin mediated by the opioid system in mice

, 2013
WOS: 000321605200004PubMed ID: 23639588In the present study, we determined the potential anti-nociceptive activity of vitexin, a C-glycosylated flavone, by conducting some acute nociceptive tests in mice.
Can, Özgür Devrim, Özkay, Ümide Demir, DEMİR ÖZKAY, ÜMİDE, Ümide Demir Özkay, Özgür Devrim Can   +4 more
core   +1 more source

Synthesis, Anti-inflammatory and Anti-nociceptive Evaluation of Palmitoyl Benzamides [PDF]

, 2014
Purpose: To synthesize and characterize palmitoyl amino benzamides, and to evaluate them for possible anti-inflammatory and anti-nociceptive activities.Methods: Palmitoyl amino benzamides were synthesized by the opening of isatoic anhydride ring with ...
Baba, H, Igbinaduwa, PO, Usifoh, CO
core   +1 more source