Results 51 to 60 of about 2,131,769 (283)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Anti-inflammatory and anti-nociceptive effects of hydroalchoholic extract of Nepeta menthoides on pain in aerial parts in male mice

فصلنامه دانشگاه علوم پزشکی جهرم, 2013
Introduction: The application of herbal plants instead of synthetic drugs has been increasing in recent years because of their lower side-effects and high varieties of efficient components.
S Asadi Balsin Sharif Abadi , S Nasri, Gh Amin, S Bidaran   +3 more
doaj   +2 more sources

The Anti-Nociception Effect of Dezocine in a Rat Neuropathic Pain Model [PDF]

Translational Perioperative and Pain Medicine, 2014
The treatment of neuropathic pain (NP) currently remains clinically challenging. In an attempt to identify novel targets of known opioids, we found that dezocine, a non-addictive opioid, inhibits norepinephrine and serotonin reuptake through their transporter proteins which open the potential for dezocine to manage NP.
Fei-Xiang, Wu, Rui-Rui, Pan, Wei-Feng, Yu, Renyu, Liu   +3 more
openaire   +2 more sources

Isolation, Identification, and Characterization of a Serine Protease with Anti-nociceptive Activity from the Gut Bacterium, Faecalibacterium prausnitzii [PDF]

Inflammatory bowel disease (IBD) induces hyperexcitability in dorsal root ganglion (DRG) nociceptors, which contributes to abdominal pain. Proteases modulate the excitability of nociceptive neurons via activation of cell-surface protease-activated ...
Taylor, Alward, Prameet, Sheth, Josh, Innis, Lorena, Ucciferri, Manasa, Ramachandra, Shu-Mei, He, Alan, Lomax, Corey, Baker, Avena, Ross   +8 more
core   +2 more sources

Evaluation of anti-nociceptive, anti-inflammatory and hepatoprotective effects of methanol extract of Mazus pumilus (Burm. f.) Steenis (Mazaceae) herb [PDF]

, 2021
Purpose: This study was designed to investigate the anti-nociceptive, anti-inflammatory and hepatoprotective activities of the methanol extract of Mazus pumilus (Mazaceae) herb.
Ishtiaq, Saiqa, Shaheen, Shabnam, Irshad, Numera, Afridi, Muhammad Shaharyar Khan, Kamran, Sairah H., Hanif, Uzma, Ilyas, Ayesha, Niaz, Uzma, Saiqa Ishtiaq, Numera Irshad, Uzma Niaz, Sairah H. Kamran, Uzma Hanif, Ayesha Ilyas, Muhammad Shaharyar Khan Afridi, Shabnam Shaheen   +15 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L.

Brazilian Journal of Pharmaceutical Sciences, 2020
Tanacetum balsamita locally called Shahesparam is an aromatic plant that grows widely in Azerbaijan Province, Iran. Due to the widespread use of T.
Maryam Sharif, Parvaneh Najafizadeh, Jinous Asgarpanah, Zahra Mousavi   +3 more
doaj   +1 more source

Data for: Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit

, 2019
Raw data: Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr ...
Yan Zhuang (115199), Fengjin Li (6638504), Jinhai Huo (6614288), Luqi Huang (130414), Weiming Wang (158128), Hongbin Xiao (2589100), Xiao, Hongbin   +6 more
core   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source