Results 121 to 130 of about 2,131,769 (283)

Single‐dose enflicoxib versus a 7‐day course of firocoxib for postoperative pain control in dogs undergoing orthopaedic surgery: A multicentre, randomised, masked, non‐inferiority study

Veterinary Record, EarlyView.
Abstract Background Perioperative analgesia is essential in dogs undergoing orthopaedic surgery, and enflicoxib's long duration makes single‐dose administration attractive. Methods A prospective, multicentre, randomised, masked trial compared enflicoxib (8 mg/kg) given 24 hours before surgery with firocoxib (5 mg/kg) given daily for 7 days. Two hundred
Marta Salichs, José I. Redondo, Anabel Blasco‐Moreno, Llorenç Badiella, Josep Homedes   +4 more
wiley   +1 more source

PROSPECT guideline for total hip arthroplasty: updated systematic review and procedure‐specific postoperative pain management recommendations

Anaesthesia, EarlyView.
Summary Introduction The Procedure Specific Postoperative Pain Management (PROSPECT) collaboration develops evidence‐based recommendations integrating analgesic efficacy, safety and functional recovery. Since publication of the 2021 PROSPECT guidelines for total hip arthroplasty, new evidence, particularly on motor‐sparing regional techniques, has ...
Michele Carella, Dario Bugada, Marc Van de Velde, Helene Beloeil, Eric Albrecht, Patricia Lavandhomme, Johan Raeder, Girish P. Joshi, on behalf of the PROSPECT Working Group of the European Society of Regional Anesthesia and Pain Therapy   +8 more
wiley   +1 more source

The Anti-Nociceptive Effects of Nicotine in Humans: A Systematic Review and Meta-Analysis. [PDF]

Pharmaceuticals (Basel), 2023
Luo Y, Yang Y, Schneider C, Balle T.
europepmc   +1 more source

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

Evaluation of anti-inflammatory, antioxidant and anti-nociceptive activities of six Malaysian medicinal plants [PDF]

, 2011
The anti-inflammatory, antioxidant and anti-nociceptive properties of six Malaysian medicinal plants, including Carica papaya, Musa acuminata, Oenanthe javanica, Piper sarmentosum, Psophocarpus tetragonolobus and Sauropus androgynus were investigated ...
Lee, Kun Hong, Ahmad Israf, Daud, Abdullah, Norhani, Ahmad, Syahida, Mahmood, Maziah, Sulaiman, Mohd Roslan, Mohd Padzil, Azyyati, Saad, Wan Zuhainis, Shaari, Khozirah, Lajis, Md. Nordin   +9 more
core   +1 more source

Anti-Nociceptive And Anti-Inflammatory Effects Of A Nigerian Polyherbal Tonic Tea (Pht) Extract In Rodents [PDF]

, 2009
The study investigated the anti-nociceptive and anti-inflammatory properties of a Nigerian Polyherbal Health Tonic tea aqueous extract (PHT) in rodents of both sexes. 100 - 500 mg kg–1 of the aqueous extract was administered via the intra-peritoneal (i.p.
Isaac, Adeleke Tijani, Oluwatoyin, Agbaje Esther, Adeneye, Adejuwon Adewale   +2 more
core  

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Evaluation of the Anti-nociceptive and Anti-inflammatory Activities of the Pet: Ether Extract of Portulaca Oleracea (Linn.) [PDF]

Journal of Clinical and Diagnostic Research, 2012
To investigate the anti-nociceptive and the anti-inflammatory activities of the petroleum-ether extract of Portulaca oleracea. The petroleum-ether extract of Portulaca oleracea was subjected to a preliminary phytochemical screening.
Jagan Rao N., Jayasree T., Mallikarjuna Rao B., Sandeep Kumar K., Vijay Kumar S.   +4 more
doaj  

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source