Results 131 to 140 of about 2,131,769 (283)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Anti Nociceptive, Anti Inflammatory and Anti Bacterial Properties of Leaf of Female Borassus flabellifer (Arecaceae) [PDF]

, 2010
: The Borassus flabellifer is a tall, erect palm, easy to recognize by its large, fan-shaped leaves. The different parts of the plant are used for ailments like secondary syphilis, antiperiodic, heart burns, liver, inflammation and spleen enlargement ...
Otilia Banji, Chaitanya R.S.N.A.K.K, Sandhya S*, Sudhakar K, David Banji,
core  

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats. [PDF]

Commun Biol, 2022
Nishimura H, Yoshimura M, Shimizu M, Sanada K, Sonoda S, Nishimura K, Baba K, Ikeda N, Motojima Y, Maruyama T, Nonaka Y, Baba R, Onaka T, Horishita T, Morimoto H, Yoshida Y, Kawasaki M, Sakai A, Muratani M, Conway-Campbell B, Lightman S, Ueta Y.   +21 more
europepmc   +1 more source

Anti-nociceptive activities of medicinal plants: A Review

RADS Journal of Biological Research & Applied Science, 2013
Medicinal plants are traditionally used in worldwide as analgesic and for treatment of inflammatory disorders. In the present review, the antinociceptive effects of plants have been discussed. Medicinal plants are gaining popularity among population due to low cost and best efficacy.
Mohammad Akram, H. M Asif, Khan Usmanghani, Abdul Hamid, Allah Nawaz   +4 more
openaire   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Ceratonia siliqua leaves ethanol extracts exert anti-nociceptive and anti-inflammatory effects. [PDF]

Heliyon, 2022
Alqudah A, Qnais EY, Wedyan MA, Oqal M, Alqudah M, AbuDalo R, Al-Hashimi N.   +6 more
europepmc   +1 more source

Phloroglucinol inhibits human ureteral contractions via activation of cAMP‐PKA pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Phloroglucinol is used to treat renal colic, especially when non‐steroidal anti‐inflammatory drugs are contraindicated. This study aimed to clarify its mechanism by examining effects on human ureteral contractility and underlying signalling pathways. Experimental Approach Urinary levels of neurokinin A (NKA), substance P
Hanwen Liu, Ruize Xu, Zihan Guan, Lei Liu, Guangda Lv, Weibo Chen, Jiliang Wen, Jianing Liu, Jieke Yan, Fangxin Gong, Pan Xiao, Xiulin Zhang, Lei Zhang   +12 more
wiley   +1 more source

Identification of a human estrogen receptor α tetrapeptidic fragment with dual antiproliferative and anti-nociceptive action. [PDF]

Sci Rep, 2023
Jouffre B, Acramel A, Belnou M, Santolla MF, Talia M, Lappano R, Nemati F, Decaudin D, Khemtemourian L, Liu WQ, Maggiolini M, Eschalier A, Mallet C, Jacquot Y.   +13 more
europepmc   +1 more source

Anti-Nociceptive Activity of Clonixin in Rhesus Monkeys

Japanese Journal of Pharmacology, 1972
CIOFALO, V.B., PATEL, J., TABER, R.I.
openaire   +2 more sources