Results 141 to 150 of about 2,131,769 (283)

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

Comparative evaluation of sedative and anti-nociceptive effects of epidural romifidine, romifidine-lidocaine, and lidocaine in donkeys (Equus asinus). [PDF]

Front Vet Sci, 2022
Marzok M, Almubarak AI, Babiker H, Kandeel M, El-Hawari SF, El-Khodery S.   +5 more
europepmc   +1 more source

The Serotonergic and Cholinergic Signaling Pathways Drive Gastric Precancerous Lesions and Its Potential Mechanism

Cancer Science, EarlyView.
Vagal cholinergic neurons promote gastric 5‐HT secretion, which drives gastric precancerous lesions through 5‐HTR1D and TRPV4, highlighting these as candidate targets for early intervention. ABSTRACT Gastric cancer (GC) is a leading lethal malignancy globally. Gastric precancerous lesion (GPL) represents a critical step in GC, but its neural regulatory
Shengli Gao, Xufei Feng, Nana Zhang, Jia Su, Yuyan Wang, Linghan Kong, Jianing Zhou, Hui Dong, Feifei Guo   +8 more
wiley   +1 more source

The anti-nociceptive effect of BPC-157 on the incisional pain model in rats. [PDF]

J Dent Anesth Pain Med, 2022
Jung YH, Kim H, Kim H, Kim E, Baik J, Kang H.   +5 more
europepmc   +1 more source

Effects of MrgC agonist and anti-MrgC on nociceptive behaviors in BCP mice.

, 2016
BCP mice were administered with BAM8-22 or anti-MrgC for 7 consecutive days (starting from day 14 after operation), and then the nociceptive behaviors were assessed at days 0, 1, 3, and 7 (Day 0-Day 7) after drug administration.
Zhengliang Ma (306283), Ming Jiang (11433), Xiaoping Gu (306278), Yu’e Sun (2735419), Bailing Hou (2735413), Cui’e Lu (2735416), Yishan Lei (2735422)   +6 more
core   +1 more source

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To map existing evidence on neuropathic pain in cerebral palsy (CP) and related genetic conditions, including prevalence, descriptors, assessment methods, and management. Method Following prospective registration, five databases (Ovid MEDLINE, Embase, CINAHL, Web of Science, Google Scholar) were searched in June 2025.
Aayushi Khillan, Sanya Verma, Hannah Yeomans, Karen Bau, Caitlin Doyle, Monica S. Cooper, David J. Amor, Carolyn Berryman, Adrienne Harvey   +8 more
wiley   +1 more source

Anti-nociceptive effect of black seed oil on an animal model of chronic constriction injury. [PDF]

Res Pharm Sci, 2022
Talaei SA, Banafshe HR, Moravveji A, Shabani M, Tehrani SS, Abed A.   +5 more
europepmc   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal Plants. [PDF]

Plants (Basel), 2022
Kagambega W, Belem H, Meda RN, Koama BK, Drabo AF, Kabore J, Traore A, Ouédraogo GA, Benedec D, Hanganu D, Vlase L, Vlase AM, Voștinaru O, Mogoșan C, Oniga I.   +14 more
europepmc   +1 more source

Radiosynoviorthesis in People With Haemophilia—Pain‐Related and Clinical Outcomes: A Prospective Controlled Cohort Study

Haemophilia, EarlyView.
ABSTRACT Introduction Radiosynoviorthesis (RSO) may alleviate pain and clinical symptoms in people with haemophilia (PwH), however, controlled longitudinal data on these outcomes remain limited. Aim To evaluate the effects of RSO on pain, joint health, swelling, and treatment satisfaction over twelve months. Methods Patients with an indication for RSO (
Alexander Schmidt, Pia Möllers, Jamil Hmida, Marius Brühl, Barbara Boddenberg‐Pätzold, Hermann Eichler, Georg Goldmann, Björn Habermann, Susan Halimeh, Johannes Oldenburg, Heinrich Richter, Fabian Tomschi, Andreas C. Strauss, Thomas Hilberg   +13 more
wiley   +1 more source