Results 221 to 230 of about 2,131,769 (283)

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

Advanced Science, Volume 13, Issue 61, 3 November 2026.
An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni, Costantino Casale, Marika Sperduti, Nevio L. Tagliamonte, Giorgia Imparato, Loredana Zollo, Paolo A. Netti   +6 more
wiley   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, Volume 100, Issue 5, Page 1039-1054, November 2026.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2246-2260, November 2026.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Phytochemical Screening, Pharmacological Evaluation, and Exploratory In Silico Analysis of Emilia sonchifolia Extract and Solvent Fractions

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Emilia sonchifolia (L.) DC. is a medicinal plant used traditionally for the management of several disorders; however, integrated experimental evaluation of its pharmacological properties remains limited. This study evaluated the phytochemical composition and selected biological activities of the methanolic whole‐plant extract of E. sonchifolia
Md. Masud Morshed, Mohammad Arman, Mohammad Nazmul Islam, Ziaul Karim, Rakibur Rahman, Mohammed Hassan Kawsar, Md. Sohel Rana   +6 more
wiley   +1 more source

A TRIP‐nano killer silencing the pain pacemakers

The Journal of Physiology, EarlyView.
Elisabetta Cerbai
wiley   +1 more source

Jing Si Herbal Tea Aqueous Extract Modulates G‐CSF‐Induced Hematopoietic Stem and Progenitor Cells Mobilization and Mitigates Associated Pain in a Murine Model

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Granulocyte colony‐stimulating factor (G‐CSF) is widely used for stem cell mobilization but is associated with side effects such as pain, which often discourages healthy donors. Jing Si Herbal Tea (JSHT), a novel Chinese herbal formula comprising eight different Chinese herbal medicines, has been shown to exert pleiotropic effects against ...
Ji‐Yan Lyu, Bruce Chi‐Kang Tsai, Chih‐Ying Chi, Yu‐Ling Wu, Wen‐Tsan Weng, Kai‐Hung Wang, Kuo‐Liang Yang, Chih‐Yang Huang, Shinn‐Zong Lin   +8 more
wiley   +1 more source

Zdhhc14 promotes pyroptosis in the dorsal root ganglion of oxaliplatin‐induced peripheral neuropathy mice by enhancing GBP5 palmitoylation and suppressing its ubiquitination

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Oxaliplatin‐induced up‐regulation of Zdhhc14 enhances GBP5 stability through palmitoylation‐dependent inhibition of ubiquitin–proteasome degradation, thereby contributing to the development of peripheral neuropathy. Zdhhc14 is identified as a key palmitoyltransferase up‐regulated in oxaliplatin‐induced peripheral neuropathy.
Xiao Jiang, Wanqiu Li, Yanzhuo Liu, Wei Song, Xuedan Zheng, Liu Tang   +5 more
wiley   +1 more source

Tendinopathy: Types, Epidemiology, Molecular Mechanisms, and Future Precision‐Oriented Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
This review presents tendinopathy as a heterogeneous disorder driven by dynamic interactions among mechanical sensing, inflammation, angiogenesis and innervation, and extracellular matrix remodeling. Integrating clinical phenotypes with imaging, biomarkers, and multi‐omics may enable molecular subtyping and mechanism‐guided interventions, advancing ...
Yang Wu, Junyi Long, Meng Yang, Hongjie Huang, Jianquan Wang   +4 more
wiley   +1 more source

Phytochemical Profiling and Safety Assessment of Maerua crassifolia Forssk. Aerial Parts Infusion With Pharmacological Validation of Its Analgesic and Anti‐Inflammatory Activities

ChemistryOpen, Volume 15, Issue 11, November 2026.
Rich in phenolic compounds, Maerua crassifolia Forssk. aerial parts infusion combines strong antioxidant capacity with a favorable acute safety profile. It produces dose‐dependent analgesic and anti‐inflammatory effects in vivo, approaching reference‐drug activity.
Leila Benazzi, Saida Ouafi, Redouane Semaoui, Faiza Baali, Jordi Eras, Ramon Canela‐Garayoa, Nadjette Djemouai   +6 more
wiley   +1 more source

Effects of Esketamine on Emergence Delirium in Children Undergoing Sevoflurane Anesthesia: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

Pediatric Anesthesia, Volume 36, Issue 11, Page 1361-1374, November 2026.
ABSTRACT Background Emergence delirium is a frequent and distressing postoperative complication in children, particularly following sevoflurane‐based anesthesia. Despite its clinical importance, the optimal preventive strategy remains under investigation.
Munder Lateiresh, Abdelaziz Louat, Mukhtar Alwefati, Alhasan Altayf, Matthieu Legrand, Phillip D. Cohen, Eman Abdulwahed, Sapna R. Kudchadkar, Muhammed Elhadi   +8 more
wiley   +1 more source