Results 51 to 60 of about 5,870,697 (401)

The impact of healthcare-associated infection on mortality: failure in clinical recognition is related with inadequate antibiotic therapy. [PDF]

PLoS ONE, 2013
PURPOSE: To understand if clinicians can tell apart patients with healthcare-associated infections (HCAI) from those with community-acquired infections (CAI) and to determine the impact of HCAI in the adequacy of initial antibiotic therapy and hospital ...
Teresa Cardoso, Orquídea Ribeiro, Irene Aragão, Altamiro Costa-Pereira, António Sarmento   +4 more
doaj   +1 more source

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection [PDF]

, 2017
Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam ...
Helps, Alieen, Irvine, Sharon C., Jones, Brian L., Ritchie, Neil D., Robb, Fiona, Seaton, R. Andrew   +5 more
core   +1 more source

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2018
Importance Short-term results support antibiotics as an alternative to surgery for treating uncomplicated acute appendicitis, but long-term outcomes are not known.
P. Salminen, R. Tuominen, H. Paajanen, T. Rautio, P. Nordström, M. Aarnio, T. Rantanen, S. Hurme, J. Mecklin, J. Sand, J. Virtanen, A. Jartti, J. Grönroos   +12 more
semanticscholar   +1 more source

Avoiding pitfalls in antibiotic therapy: the antibiotic stewardship approach

Magna Scientia UCEVA, 2022
The aim of this reflection is to determine the effectiveness and safety of ABS interventions. A strong correlation between antibiotic overuse and the growing worldwide resistance, but also with individual side effects is well established and should open
Markus H. Huppertz-Thyssen, Carolina Rodriguez Saavedra   +1 more
doaj   +1 more source

Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]

, 2017
In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De, Mascellino, Maria Teresa, Oliva, Alessandra   +2 more
core   +1 more source

Seven versus fourteen Days of Antibiotic Therapy for uncomplicated Gram-negative Bacteremia: a Non-inferiority Randomized Controlled Trial.

Clinical Infectious Diseases, 2018
Background Gram-negative bacteremia is a major cause of morbidity and mortality in hospitalized patients. Data to guide the duration of antibiotic therapy are limited. Methods Randomized, multicenter, open-label, non-inferiority trial.
D. Yahav, E. Franceschini, Fidi Koppel, A. Turjeman, T. Babich, R. Bitterman, A. Neuberger, Nesrin Ghanem-Zoubi, A. Santoro, N. Eliakim‐Raz, B. Pertzov, T. Steinmetz, A. Stern, Y. Dickstein, Elias Maroun, H. Zayyad, J. Bishara, D. Alon, Y. Edel, E. Goldberg, C. Venturelli, C. Mussini, L. Leibovici, M. Paul   +23 more
semanticscholar   +1 more source

Rapid molecular testing is associated with decreased broad-spectrum antibiotic use among patients with streptococcal bloodstream infections

Antimicrobial Stewardship & Healthcare Epidemiology
We investigated the impact of rapid diagnostic testing with real-time stewardship intervention on patients with Streptococcal bacteremia. Compared to pre-intervention, patients in the post-intervention group received more rapid antibiotic de-escalation ...
Tyler Tate, J. Alex Viehman, Ryan K. Shields   +2 more
doaj   +1 more source

Expected Practice as a Novel Antibiotic Stewardship Intervention. [PDF]

, 2019
"Expected practice" is a recently described method to alter clinical behavior. We implemented an expected practice around short-course antibiotic therapy, which was associated with decreased antibiotic utilization for multiple bacterial infections. Thus,
Masuda, Eriko, Minejima, Emi, Spellberg, Brad, Yadav, Kabir   +3 more
core  

The role of microbiology and pharmacy departments in the stewardship of antibiotic prescribing in European hospitals [PDF]

, 2007
This observational, cross-sectional study describes the role played by clinical microbiology and pharmacy departments in the stewardship of antibiotic prescribing in European hospitals.
Bruce, Julie, Cookson, Barry, Gould, I.M., Krcmery, Vladimir, MacKenzie, Fiona, Mollison, Jill, Monnet, Dominique L., van der Meer, Jos W.M.   +7 more
core   +1 more source

Antibiotic therapy and outcome from immune-checkpoint inhibitors

Journal of Immunotherapy for Cancer, 2019
Sensitivity to immune checkpoint inhibitor (ICPI) therapy is governed by a complex interplay of tumor and host-related determinants. Epidemiological studies have highlighted that exposure to antibiotic therapy influences the probability of response to ...
D. Pinato, Daria Gramenitskaya, D. Altmann, R. Boyton, B. Mullish, J. Marchesi, M. Bower   +6 more
semanticscholar   +1 more source