Results 1 to 10 of about 951,830 (223)

Complexes of antitubercular antibiotics with cellulose sulfate acetate

Proceedings of the National Academy of Sciences of Belarus, Chemical Series, 2020
Water-insoluble complexes of antituberculosis antibiotics (AB) kanamycin (CNMC), amikacin (AMCC) and capreomycin (CPRMC), traditionally used parenterally, with cellulose acetate sulphate in the form of sodium salt (Na-SAC) were obtained. The possibility of their immobilization on the activated carbon (AC) to create a tablet form of AB was demonstrated.
T. A. Savitskaya, K. A. Shakhno, D. D. Grinshpan, O. A. Ivashkevich   +3 more
openaire   +3 more sources

Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies.

PLoS ONE, 2022
A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods.
Surendra Babu Lagu, Rajendra Prasad Yejella, Srinath Nissankararao, Richie R Bhandare, Venu Sampath Golla, Bontha Venkata Subrahmanya Lokesh, M Mukhlesur Rahman, Afzal Basha Shaik   +7 more
doaj   +3 more sources

Tandem LC-MS Identification of Antitubercular Compounds in Zones of Growth Inhibition Produced by South African Filamentous Actinobacteria

Molecules, 2023
Novel antitubercular compounds are urgently needed to combat drug-resistant Mycobacterium tuberculosis (Mtb). Filamentous actinobacteria have historically been an excellent source of antitubercular drugs.
Daniel J. Watson, Lubbe Wiesner, Tlhalefo Matimela, Denzil Beukes, Paul R. Meyers   +4 more
doaj   +2 more sources

Persistent Fever Despite Antitubercular Therapy: Unmasking Haemophagocytic Lymphohistiocytosis Triggered by Disseminated Tuberculosis. [PDF]

Cureus
Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition that can complicate various infections, including Mycobacterium tuberculosis infection.
Galea A, Tabone Adami N, Xerri T, Farrugia D, Vella C.   +4 more
europepmc   +2 more sources

Inhalable fucoidan microparticles combining two antitubercular drugs with potential application in pulmonary tuberculosis therapy [PDF]

Polymers, 2018
The pulmonary delivery of antitubercular drugs is a promising approach to treat lung tuberculosis. This strategy not only allows targeting the infected organ instantly, it can also reduce the systemic adverse effects of the antibiotics. In light of that,
Ana Grenha, Ana Rosa da Costa, Buttini, Francesca Buttini, Ludmylla Cunha, M Faleiro, Stefaniak-Vidarsson, Susana Rodrigues   +7 more
core   +3 more sources

Early Drug Development and Evaluation of Putative Antitubercular Compounds in the -Omics Era

Frontiers in Microbiology, 2021
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. According to the WHO, the disease is one of the top 10 causes of death of people worldwide.
Alina Minias, Lidia Żukowska, Lidia Żukowska, Ewelina Lechowicz, Ewelina Lechowicz, Filip Gąsior, Filip Gąsior, Agnieszka Knast, Agnieszka Knast, Sabina Podlewska, Sabina Podlewska, Daria Zygała, Daria Zygała, Jarosław Dziadek   +13 more
doaj   +2 more sources

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. [PDF]

PLoS ONE, 2015
Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug resistant TB.
Magdalena Makowska-Grzyska, Youngchang Kim, Suresh Kumar Gorla, Yang Wei, Kavitha Mandapati, Minjia Zhang, Natalia Maltseva, Gyan Modi, Helena I Boshoff, Minyi Gu, Courtney Aldrich, Gregory D Cuny, Lizbeth Hedstrom, Andrzej Joachimiak   +13 more
doaj   +2 more sources

Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis [PDF]

Frontiers in Immunology, 2017
Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment.
Javier Arranz-Trullén, Javier Arranz-Trullén, Lu Lu, David Pulido, Sanjib Bhakta, Ester Boix   +5 more
doaj   +4 more sources

Exploring the structural aspects of alanine racemase enzyme for antitubercular drug discovery – a computational approach

Journal of Applied Pharmaceutical Research
Background: Tuberculosis (TB) is a communicable disease that is a significant cause of ill health and one of the leading causes of death worldwide. The current antibiotics have been pivotal in managing TB to a greater extent.
Unni Jayaram, Parthan Anilkumar, Fathima Rifana Yousuf, Graceson Jose   +3 more
doaj   +2 more sources

Retro-inversion imparts antimycobacterial specificity to host defense peptides [PDF]

Nature Communications
Antimicrobial host defense peptides are promising alternatives to resistance prone small molecule antibiotics. To overcome the poor physiologic stability of these therapeutic candidates it is common to prepare proteolytically resistant retro-inverso ...
Hugh D. Glossop, Gebremichal Gebretsadik, Sabiha Sultana, Diptomit Biswas, Nathan A. Schacht, Neela H. Yennawar, Muzafar Ahmad Rather, Anthony D. Baughn, Scott H. Medina   +8 more
doaj   +2 more sources