Results 1 to 10 of about 6,983 (163)

Retro-inversion imparts antimycobacterial specificity to host defense peptides [PDF]

Nature Communications
Antimicrobial host defense peptides are promising alternatives to resistance prone small molecule antibiotics. To overcome the poor physiologic stability of these therapeutic candidates it is common to prepare proteolytically resistant retro-inverso ...
Hugh D. Glossop, Gebremichal Gebretsadik, Sabiha Sultana, Diptomit Biswas, Nathan A. Schacht, Neela H. Yennawar, Muzafar Ahmad Rather, Anthony D. Baughn, Scott H. Medina   +8 more
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The MAB_3513c gene plays a key role in intrinsic resistance of Mycobacterium abscessus to isoniazid and ethionamide [PDF]

Microbiology Spectrum
Isoniazid (INH) and ethionamide (ETH) are important antitubercular analogs that inhibit mycolic acid synthesis. However, Mycobacterium abscessus (M. abscessus) exhibits intrinsic resistance to both drugs.
Shuai Wang, Xiaofan Zhang, Xiange Fang, H. M. Adnan Hameed, Abdul Malik, Lihua Long, Yamin Gao, Cuiting Fang, Xirong Tian, Jinxing Hu, Xingyue Wang, Liqiang Feng, Tianyu Zhang   +12 more
doaj   +2 more sources

Drug induced liver injury: East versus West – a systematic review and meta-analysis [PDF]

Clinical and Molecular Hepatology, 2020
Drug induced liver injury (DILI) may be different in the East compared to the West due to differing disease prevalence, prescribing patterns and pharmacogenetic profiles.
En Xian Sarah Low, Qishi Zheng, Edwin Chan, Seng Gee Lim   +3 more
doaj   +1 more source

Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies.

PLoS ONE, 2022
A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods.
Surendra Babu Lagu, Rajendra Prasad Yejella, Srinath Nissankararao, Richie R Bhandare, Venu Sampath Golla, Bontha Venkata Subrahmanya Lokesh, M Mukhlesur Rahman, Afzal Basha Shaik   +7 more
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A Case Report on Disseminated Tuberculosis in a Newborn [PDF]

Pediatric Infectious Disease, 2023
Congenital tuberculosis (CTB) is a rare and challenging diagnosis with high mortality. As one of the many differentials for newborn sepsis, it should be considered when neonates deteriorate despite broad-spectrum antibiotics.
Sachin Bhagat, Mangla Sood, Parveen Bhardwaj   +2 more
doaj   +1 more source

Tandem LC-MS Identification of Antitubercular Compounds in Zones of Growth Inhibition Produced by South African Filamentous Actinobacteria

Molecules, 2023
Novel antitubercular compounds are urgently needed to combat drug-resistant Mycobacterium tuberculosis (Mtb). Filamentous actinobacteria have historically been an excellent source of antitubercular drugs.
Daniel J. Watson, Lubbe Wiesner, Tlhalefo Matimela, Denzil Beukes, Paul R. Meyers   +4 more
doaj   +1 more source

Synthesis of 2-(6-substituted quinolin-4-yl)-1-(4-aryl-1H-1,2,3-triazol-1-yl) propan-2-ol as potential antifungal and antitubercular agents

European Journal of Medicinal Chemistry Reports, 2023
The intense pressure of resistance to antibiotics leads the whole world's health security to drastic conditions due to Mycobacterial and fungal infections.
Abhijit Shinde, Prashant P. Thakare, Yogesh Nandurkar, Manish Bhoye, Abhijit Chavan, Pravin C. Mhaske   +5 more
doaj   +1 more source

The challenge of managing extensively drug-resistant tuberculosis at a referral hospital in the state of São Paulo, Brazil: a report of three cases [PDF]

Jornal Brasileiro de Pneumologia, 2015
Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test results,
Marcos Abdo Arbex, Hélio Ribeiro de Siqueira, Lia D'Ambrosio, Giovanni Battista Migliori   +3 more
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Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. [PDF]

PLoS ONE, 2015
Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug resistant TB.
Magdalena Makowska-Grzyska, Youngchang Kim, Suresh Kumar Gorla, Yang Wei, Kavitha Mandapati, Minjia Zhang, Natalia Maltseva, Gyan Modi, Helena I Boshoff, Minyi Gu, Courtney Aldrich, Gregory D Cuny, Lizbeth Hedstrom, Andrzej Joachimiak   +13 more
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An Unusual Case of Renal Infection with Mycobacterium senegalense [PDF]

Journal of Clinical and Diagnostic Research, 2023
Mycobacterium senegalense is a Non Tuberculous Mycobacteria (NTM) belonging to rapid growers Mycobacterium fortuitum group. Authors describe a unique case of Mycobacterium senegalense infection in a 62-year-old diabetic male with bilateral pyelonephritis
Jennifer Maria Selvakani, Priyadarshini Shanmugam, R Alice Peace Selvabai, Vigneshwaaran Jayasekaran   +3 more
doaj   +1 more source