Results 21 to 30 of about 951,869 (260)

Multifunctional nanocarriers for lung drug delivery [PDF]

, 2020
Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical ...
Grenha, Ana, Pontes, Jorge Filipe
core   +2 more sources

Quinolone analogues of benzothiazinone: Synthesis, antitubercular structure-activity relationship and ADME profiling.

European journal of medicinal chemistry, 2023
Mycobacterium tuberculosis (Mtb) has an impermeable cell wall which gives it an inherent ability to resist many antibiotics. DprE1, an essential enzyme in Mtb cell wall synthesis, has been validated as a target for several TB drug candidates.
Phelelisiwe S. Dube, L. Legoabe, Audrey Jordaan, Lester T. Sigauke, D. Warner, Richard M. Beteck   +5 more
semanticscholar   +1 more source

A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics

PLoS Biology, 2022
The Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) presents here a data compendium of 12,289 Mycobacterium tuberculosis global clinical isolates, all of which have undergone whole-genome sequencing and have ...
D. Crook, T. Peto, S. Hoosdally, A. G. Cruz, A., S. Walker, T. Walker, P. Fowler, Z. Iqbal, D. Cirillo, A. Brankin, Kerri M. Malone, Martin Hunt, Jeff Knaggs, N. Mistry, Camilla Rodrigues, David A. J. Moore, N. Ismail, S. Niemann, A. Roohi, B. Letcher, P. Rancoita, E. Borroni, Clara Grazian   +23 more
semanticscholar   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Antitubercular, Cytotoxicity, and Computational Target Validation of Dihydroquinazolinone Derivatives

Antibiotics, 2022
A series of 2,3-dihydroquinazolin-4(1H)-one derivatives (3a–3m) was screened for in vitro whole-cell antitubercular activity against the tubercular strain H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains.
Katharigatta N. Venugopala, N. Al-Shar’i, Lina A. Dahabiyeh, W. Hourani, P. Deb, M. Pillay, Bashaer Abu-Irmaileh, Yasser K. Bustanji, Sandeep Chandrashekharappa, C. Tratrat, M. Attimarad, Anroop B Nair, N. Sreeharsha, P. Shinu, M. Haroun, Mahmoud Kandeel, A. Balgoname, Rashmi Venugopala, M. A. Morsy   +18 more
semanticscholar   +1 more source

A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates

eLife, 2022
Tuberculosis is a respiratory disease that is treatable with antibiotics. An increasing prevalence of resistance means that to ensure a good treatment outcome it is desirable to test the susceptibility of each infection to different antibiotics ...
Philip W. Fowler, Carla Wright, Helen Spiers, T. Zhu, E. Baeten, Sarah W Hoosdally, Ana Gibertoni Cruz, A. Roohi, S. Kouchaki, T. M. Walker, Timothy E. A. Peto, Grant Miller, C. Lintott, David A. Clifton, Derrick W. Crook, A. S. Walker, Ivan Simone Emanuele Angela Pires Alice Andrea Maurizio Barilar Battaglia Borroni Brandao Brankin Cabibbe , I. Barilar, S. Battaglia, E. Borroni, Angela Pires Brandão, A. Brankin, A. Cabibbe, Joshua Carter, D. Cirillo, P. Claxton, David A. Clifton, Ted Cohen, J. Coronel, Derrick W. Crook, S. Earle, V. Escuyer, L. Ferrazoli, Philip W. Fowler, G. F. Gao, Jennifer Gardy, Saheer Gharbia, K. T. Ghisi, A. Ghodousi, Ana Gibertoni Cruz, C. Grazian, Jennifer L. Guthrie, Wencong He, Harald Hoffmann, S. Hoosdally, M. Hunt, Z. Iqbal, N. Ismail, Lisa Jarrett, L. Joseph, Ruwen Jou, Priti Kambli, Jeff Knaggs, Anastasia Koch, D. Kohlerschmidt, S. Kouchaki, Alexander S Lachapelle, A. Lalvani, S. Lapierre, I. Laurenson, B. Letcher, Wan-Hsuan Lin, Chunfa Liu, Dongxin Liu, K. Malone, Ayan Mandal, D. Matias, G. Meintjes, Flavia Freitas Mendes, M. Merker, M. Mihalić, J. Millard, P. Miotto, Nerges Mistry, D. Moore, V. Dreyer, Darren Chetty, K. Musser, D. Ngcamu, H. N. Nhung, Louis Grandjean, K. Nilgiriwala, Camus Nimmo, N. Okozi, R. Oliveira, S. V. Omar, N. Paton, Timothy E. A. Peto, Juliana Maira Watanabe Pinhata, S. Plesnik, Z. M. Puyén, M. Rabodoarivelo, N. Rakotosamimanana, P. M. Rancoita, Priti Rathod, E. Robinson, G. Rodger, Camilla Rodrigues, T. Rodwell, A. Roohi, D. Santos-Lázaro, Sanchi Shah, T. Kohl, Grace Smith, W. Solano, A. Spitaleri, P. Supply, A. Steyn, Utkarsha Surve, S. Tahseen, N. Thuong, G. Thwaites, Katharina Todt, A. Trovato, C. Utpatel, Annelies Van Rie, Srinivasan Vijay, T. M. Walker, A. S. Walker, Robin Warren, J. Werngren, R. Groenheit, Maria Wijkander, Robert J Wilkinson, D. Wilson, Penelope Wintringer, Yunfei Xiao, Yang Yang, Yanlin Zhao, Shen Yao, Baoli Zhu, Stefan Niemann, Max O’Donnell   +132 more
semanticscholar   +1 more source

Fever work-up unfolds a rare diagnosis of native valve endocarditis caused by Mycobacterium abscessus

Indian Journal of Pathology and Microbiology, 2019
Endocarditis caused by Mycobacterium abscessus is rare and often missed without appropriate blood cultures. It does not respond to standard antitubercular treatment and is also resistant to many other antibiotics.
Anita Sharma, Irneet Mundi, Karun Behal, Navreet Kaur, Pooja Singh, Manish Mahant   +5 more
doaj   +1 more source

Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma

Journal of antibiotics (Tokyo. 1968), 2021
Antitubercular lanostane triterpenoids isolated from mycelial cultures of the basidiomycete Ganoderma australe were structurally modified by semisynthesis. One of the synthetic compounds, named GA003 (9), showed more potent activity against Mycobacterium
Panida Chinthanom, V. Vichai, K. Dokladda, Malipan Sappan, Chawanee Thongpanchang, M. Isaka   +5 more
semanticscholar   +1 more source

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues [PDF]

, 2013
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis ...
A Alahari, A Alahari, A Banerjee, A Bhatt, AE Grzegorzewicz, AK Ojha, AR Baulard, C Vilcheze, CK Stover, D Fegan, D Fegan, Derek Craig, E Dubnau, E Sacco, Emilie Vialla, F Wang, FM Shahab, G Lutfalla, Geoffrey D. Coxon, JA Caminero, Jean Louis Herrmann, JM Belardinelli, JR Wei, K Takayama, L Kremer, Laila Gannoun-Zaki, Laurent Kremer, LE Bermudez, LG Dover, LS Kremer, MA Espinal, MS Glickman, N Slama, P Nunn, PT Davidson, R Mondal, R Veyron-Churlet, R Veyron-Churlet, RM Corrales, Rosa Milagros Corrales, S Cantaloube, TD Bugg, V Rao, VK Sambandamurthy, Y Rombouts   +44 more
core   +9 more sources

Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]

, 2017
Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D., Buttini, Francesca, Cavaco, Joana S., Grenha, Ana, Guerreiro, Filipa, Pontes, Jorge Filipe, Rodrigues, Susana, Rosa Da Costa, Ana   +7 more
core   +1 more source