Results 21 to 30 of about 842,782 (192)

Synthesis of 2-(6-substituted quinolin-4-yl)-1-(4-aryl-1H-1,2,3-triazol-1-yl) propan-2-ol as potential antifungal and antitubercular agents

European Journal of Medicinal Chemistry Reports, 2023
The intense pressure of resistance to antibiotics leads the whole world's health security to drastic conditions due to Mycobacterial and fungal infections.
Abhijit Shinde, Prashant P. Thakare, Yogesh Nandurkar, Manish Bhoye, Abhijit Chavan, Pravin C. Mhaske   +5 more
doaj   +1 more source

A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics

PLoS Biology, 2022
The Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) presents here a data compendium of 12,289 Mycobacterium tuberculosis global clinical isolates, all of which have undergone whole-genome sequencing and have ...
D. Crook, T. Peto, S. Hoosdally, A. L. G. Cruz, A., S. Walker, T. Walker, P. Fowler, Z. Iqbal, D. Cirillo, A. Brankin, Kerri M. Malone, Martin Hunt, Jeff Knaggs, N. Mistry, Camilla Rodrigues, David A. J. Moore, N. Ismail, S. Niemann, A. Roohi, B. Letcher, P. Rancoita, E. Borroni, Clara Grazian   +23 more
semanticscholar   +1 more source

Miliary TB Without Microbiological Confirmation in a Post-Menopausal Female: A Case From a High-Burden Region. [PDF]

Clin Case Rep
ABSTRACT Miliary tuberculosis (TB) presents significant diagnostic challenges in resource‐limited, high‐burden regions when microbiological confirmation is unattainable. We describe a 65‐year‐old post‐menopausal Nepalese woman with prolonged fever, anemia, and constitutional symptoms.
Miya JA, Bhandari S, Adhikari P.
europepmc   +2 more sources

The challenge of managing extensively drug-resistant tuberculosis at a referral hospital in the state of São Paulo, Brazil: a report of three cases [PDF]

Jornal Brasileiro de Pneumologia, 2015
Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test results,
Marcos Abdo Arbex, Hélio Ribeiro de Siqueira, Lia D'Ambrosio, Giovanni Battista Migliori   +3 more
doaj   +3 more sources

Inhalable spray-dried chondroitin sulphate microparticles: effect of different solvents on particle properties and drug activity [PDF]

, 2020
Spray-drying stands as one of the most used techniques to produce inhalable microparticles, but several parameters from both the process and the used materials affect the properties of the resulting microparticles.
Buttini, Francesca, da Costa, Ana M Rosa, Faleiro, Maria Leonor, Flórez Fernández, Noelia, Grenha, Ana, Rodrigues, Susana, Torres, María Dolores   +6 more
core   +1 more source

Complexes of antitubercular antibiotics with cellulose sulfate acetate

Proceedings of the National Academy of Sciences of Belarus Chemical Series, 2020
Water-insoluble complexes of antituberculosis antibiotics (AB) kanamycin (CNMC), amikacin (AMCC) and capreomycin (CPRMC), traditionally used parenterally, with cellulose acetate sulphate in the form of sodium salt (Na-SAC) were obtained.
T. Savitskaya, K. A. Shakhno, D. Grinshpan, O. Ivashkevich   +3 more
semanticscholar   +1 more source

Antitubercular, Cytotoxicity, and Computational Target Validation of Dihydroquinazolinone Derivatives

Antibiotics, 2022
A series of 2,3-dihydroquinazolin-4(1H)-one derivatives (3a–3m) was screened for in vitro whole-cell antitubercular activity against the tubercular strain H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains.
Katharigatta N. Venugopala, N. Al-Shar’i, Lina A. Dahabiyeh, W. Hourani, P. Deb, M. Pillay, Bashaer Abu-Irmaileh, Yasser K. Bustanji, Sandeep Chandrashekharappa, C. Tratrat, M. Attimarad, Anroop B Nair, N. Sreeharsha, P. Shinu, M. Haroun, Mahmoud Kandeel, A. Balgoname, Rashmi Venugopala, M. A. Morsy   +18 more
semanticscholar   +1 more source

A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates

eLife, 2022
Tuberculosis is a respiratory disease that is treatable with antibiotics. An increasing prevalence of resistance means that to ensure a good treatment outcome it is desirable to test the susceptibility of each infection to different antibiotics ...
P. Fowler, Carla Wright, Helen Spiers, T. Zhu, E. Baeten, Sarah W Hoosdally, A. G. Gibertoni Cruz, A. Roohi, S. Kouchaki, T. Walker, T. Peto, Grant Miller, C. Lintott, D. Clifton, D. Crook, A. Walker   +15 more
semanticscholar   +1 more source

An Unusual Case of Renal Infection with Mycobacterium senegalense [PDF]

Journal of Clinical and Diagnostic Research, 2023
Mycobacterium senegalense is a Non Tuberculous Mycobacteria (NTM) belonging to rapid growers Mycobacterium fortuitum group. Authors describe a unique case of Mycobacterium senegalense infection in a 62-year-old diabetic male with bilateral pyelonephritis
Jennifer Maria Selvakani, Priyadarshini Shanmugam, R Alice Peace Selvabai, Vigneshwaaran Jayasekaran   +3 more
doaj   +1 more source

Multifunctional nanocarriers for lung drug delivery [PDF]

, 2020
Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical ...
Grenha, Ana, Pontes, Jorge Filipe
core   +2 more sources