Results 41 to 50 of about 6,983 (163)

GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876

Microbiology Spectrum, 2023
ABSTRACT The Mycobacterium tuberculosis ( Mtb ) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target and discovered the novel diaminopyrimidine
Priya Ragunathan, Pearly Shuyi Ng, Samsher Singh, Wee Han Poh, Dennis Litty, Nitin Pal Kalia, Simon Larsson, Amaravadhi Harikishore, Scott A. Rice, Philip W. Ingham, Volker Müller, Garrett Moraski, Marvin J. Miller, Thomas Dick, Kevin Pethe, Gerhard Grüber   +15 more
openaire   +4 more sources

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

ChemistryOpen, Volume 15, Issue 1, January 2026.
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten, Raushan Koizhaiganova, Dilnaz Bissenbay, Bagila Tursynova, Zhanar Zhaxibayeva, Valentina Yu   +5 more
wiley   +1 more source

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source

Inhaled microparticles of antitubercular antibiotic for in vitro and in vivo alveolar macrophage targeting and activation of phagocytosis [PDF]

The Journal of Antibiotics, 2014
Tuberculosis (TB) is a chronic infectious disease with increasing incidence of drug resistance. Oral treatment for TB and multidrug resistance-TB can have serious side effects. The causative agent of TB, Mycobacterium tuberculosis, resides in alveolar macrophages (AMs).
Rajesh, Parikh, Sonali, Dalwadi, Pooja, Aboti, Leena, Patel   +3 more
openaire   +2 more sources

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Antibacterial and Antibiofilm Activity of 8‐Hydroxyquinoline Derivatives Against Mycobacterium and Staphylococcus Species

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Synthesis of 8‐hydroxyquinoline derivatives (QD 1‐12) from different analogues of 8‐hydroxyquinoline (HQ 1‐4). The derivatives and parent compounds were evaluated for antibacterial and antibiofilm activity against Mycobacterium tuberculosis, Mycobacterium smegmatis, methicillin‐resistant Staphylococcus aureus and methicillin‐sensitive Staphylococcus ...
Namrita Lall, Anna‐Mari Kok, Carel B. Oosthuizen, Surjeet Verma, François Chassagne, Phuc H. Vo, Khanh‐Van Ho, Chung‐Ho Lin, Cassandra L. Quave, Danielle Twilley   +9 more
wiley   +1 more source

Exploring the structural aspects of alanine racemase enzyme for antitubercular drug discovery – a computational approach

Journal of Applied Pharmaceutical Research
Background: Tuberculosis (TB) is a communicable disease that is a significant cause of ill health and one of the leading causes of death worldwide. The current antibiotics have been pivotal in managing TB to a greater extent.
Unni Jayaram, Parthan Anilkumar, Fathima Rifana Yousuf, Graceson Jose   +3 more
doaj   +1 more source

Inadvertent provocative oral ondansetron use leading to toxic epidermal necrolysis in an HIV-infected patient

Indian Journal of Dermatology, 2012
Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction to drugs, characterized by extensive detachment of epidermis and mucous membranes with a mortality of 30-40%.
Punit P Saraogi, Chitra S Nayak, Rickson R Pereira, Rachita S Dhurat   +3 more
doaj   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Quinoline: A versatile bioactive scaffold and its molecular hybridization

Results in Chemistry
Quinolines have become essential to many drugs, including broad-spectrum antibiotics, antivirus, antitubercular, and antimalarial agents. Owing to their importance in medicinal and pharmaceutic industries, several studies have been conducted to ...
Ibrahim A. Bala, Ohoud F. Al Sharif, Abdullah M. Asiri, Reda M. El-Shishtawy   +3 more
doaj   +1 more source