Results 61 to 70 of about 10,695 (225)

Comprehensive Analysis of Structure Activity Relationships in Quinoxaline Derivatives Covering Antimicrobial Applications

ChemistrySelect, Volume 11, Issue 14, 13 April 2026.
ABSTRACT Antimicrobial resistance (AMR) has emerged as one of the most critical global health challenges, undermining the clinical efficacy of existing antibiotics and threatening modern therapeutic strategies. The ongoing misuse and overuse of antimicrobial agents have accelerated the evolution of resistant bacterial strains and parasites ...
Subham Kumar Vishwakarma, Fernando Rogério Pavan, Cesar Augusto Roque‐Borda   +2 more
wiley   +1 more source

Nucleophilic substitution of a phthalimidyl group with morpholine in an N1‐methyl‐1,2,3‐triazole: crystallographic evidence for migration of the methylene bridge

Acta Crystallographica Section C, Volume 82, Issue 4, Page 144-150, April 2026.
X‐ray crystallography revealed that the reaction of 2‐{[4‐(4‐bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide with morpholine led to substitution of the phthalimide group, including migration of the substituent from N1 to N2 on the 1,2,3‐triazole ring.2‐{[4‐(4‐Bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide, C17H11BrN4O, was synthesized by ...
Paul R. Palme, Richard Goddard, Markus Leutzsch, Adrian Richter, Peter Imming, Rüdiger W. Seidel   +5 more
wiley   +1 more source

Synthesis, Biological Evaluation, and Theoretical Study of Indenoquinolinylphosphine Oxide Derivatives as Topoisomerase 1 Inhibitors and Antiproliferative Agents

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
The topoisomerase I inhibition and antiproliferative activities of phosphorated indenoquinoline derivatives were investigated. The target hybrid quinoline and tetrahydroquinoline compounds were synthesized via a two‐step Povarov‐type cycloaddition.
Alba Rodriguez, Elena Formoso, Birgitta R. Knudsen, Cinzia Tesauro, Maria Fuertes, Concepcion Alonso   +5 more
wiley   +1 more source

Inhaled microparticles of antitubercular antibiotic for in vitro and in vivo alveolar macrophage targeting and activation of phagocytosis [PDF]

The Journal of Antibiotics, 2014
Tuberculosis (TB) is a chronic infectious disease with increasing incidence of drug resistance. Oral treatment for TB and multidrug resistance-TB can have serious side effects. The causative agent of TB, Mycobacterium tuberculosis, resides in alveolar macrophages (AMs).
Rajesh, Parikh, Sonali, Dalwadi, Pooja, Aboti, Leena, Patel   +3 more
openaire   +2 more sources

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis [PDF]

, 2017
The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol
Brothers, Robert C, Dowd, Cynthia S, Edwards, Rachel L, Hruz, Paul W, Kraft, Thomas E, Maron, Maxim I, Odom John, Audrey R, Tsang, Patricia S, Wang, Xu, Williamson, Kim C, Ziniel, Peter D   +10 more
core   +2 more sources

Quinoline: A versatile bioactive scaffold and its molecular hybridization

Results in Chemistry
Quinolines have become essential to many drugs, including broad-spectrum antibiotics, antivirus, antitubercular, and antimalarial agents. Owing to their importance in medicinal and pharmaceutic industries, several studies have been conducted to ...
Ibrahim A. Bala, Ohoud F. Al Sharif, Abdullah M. Asiri, Reda M. El-Shishtawy   +3 more
doaj   +1 more source

Inadvertent provocative oral ondansetron use leading to toxic epidermal necrolysis in an HIV-infected patient

Indian Journal of Dermatology, 2012
Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction to drugs, characterized by extensive detachment of epidermis and mucous membranes with a mortality of 30-40%.
Punit P Saraogi, Chitra S Nayak, Rickson R Pereira, Rachita S Dhurat   +3 more
doaj   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Exploring the structural aspects of alanine racemase enzyme for antitubercular drug discovery – a computational approach

Journal of Applied Pharmaceutical Research
Background: Tuberculosis (TB) is a communicable disease that is a significant cause of ill health and one of the leading causes of death worldwide. The current antibiotics have been pivotal in managing TB to a greater extent.
Unni Jayaram, Parthan Anilkumar, Fathima Rifana Yousuf, Graceson Jose   +3 more
doaj   +1 more source