Results 71 to 80 of about 10,695 (225)

VanA Mediated Glycopeptide Resistant Enterococcus faecium (GRE) Infection in an Elderly Patient with Chronic Kidney Disease – A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2018
A 66-year-old male patient who is a known case of chronic kidney disease was admitted to the hospital with complaint of seizures. He was uremic and showed signs of encephalopathy.
Martin Jane Esther, PK Rath, R Gopalakrishnan   +2 more
doaj   +1 more source

Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis [PDF]

, 2013
SummaryBiotin biosynthesis is essential for survival and persistence of Mycobacterium tuberculosis (Mtb) in vivo. The aminotransferase BioA, which catalyzes the antepenultimate step in the biotin pathway, has been established as a promising target due to
Park, Sae Woong, Casalena, Dominick E., Wilson, Daniel J., Dai, Ran, Nag, Partha P., Liu, Feng, Boyce, Jim P., Bittker, Joshua A., Schreiber, Stuart L., Finzel, Barry C., Schnappinger, Dirk, Aldrich, Courtney C.   +11 more
core   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, Volume 15, Issue 2, 14 January 2026.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source

Inhalable antitubercular therapy mediated by locust bean gum microparticles [PDF]

, 2016
Tuberculosis remains a major global health problem and alternative therapeutic approaches are needed. Considering the high prevalence of lung tuberculosis (80% of cases), the pulmonary delivery of antitubercular drugs in a carrier system capable of ...
Alves, Ana, Cavaco, Joana, Costa, Ana M. Rosa da, Grenha, Ana, Guerreiro, Filipa, Lourenço, J. P.   +5 more
core   +2 more sources

Antimicrobial resistance from a One Health perspective in Zambia: a systematic review

Antimicrobial Resistance and Infection Control, 2023
Background Antimicrobial resistance (AMR) is widely acknowledged as a global health problem, yet its extent is not well evaluated, especially in low-middle income countries.
Avis A. Nowbuth, Akwi W. Asombang, Nkengeh N. Tazinkeng, Opeoluwa Y. Makinde, Lincoln R. Sheets   +4 more
doaj   +1 more source

DESM: portal for microbial knowledge exploration systems [PDF]

, 2015
Microorganisms produce an enormous variety of chemical compounds. It is of general interest for mi-crobiology and biotechnology researchers to have means to explore information about molecular and genetic basis of functioning of different microor-ganisms
Adil Salhi, Aleksandar Radovanovic, Ameerah Bokhari, Andre Antunes, Benoit Marchand, Bouma, Feras F. Lafi, Ghofran Othum, Intikhab Allam, John A. C. Archer, Katsuhiko Mineta, Magbubah Essack, Marta Filipa Simoes, Olaa A. Motwalli, Robert Hoehndorf, Salim Bougouffa, Sasaya, Soha Al Amoudi, Takashi Gojobori, Tariq Malas, Vladimir B. Bajic, Wayne, Xin Gao   +22 more
core   +1 more source

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

ChemistryOpen, Volume 15, Issue 1, January 2026.
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten, Raushan Koizhaiganova, Dilnaz Bissenbay, Bagila Tursynova, Zhanar Zhaxibayeva, Valentina Yu   +5 more
wiley   +1 more source

Drug-Induced Musculoskeletal Syndromes and Soft-Tissue Rheumatism

Indian Journal of Rheumatology, 2019
Drug-induced musculoskeletal syndromes represent a broad clinical spectrum, ranging from asymptomatic biological abnormalities to severe organ-threatening manifestations. Many drugs have been implicated in inducing rheumatological adverse events.
Rudra Prosad Goswami, Parasar Ghosh
doaj   +1 more source

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source