Results 61 to 70 of about 951,869 (260)

Functional Whole Genome Screen of Nutrient-Starved Mycobacterium tuberculosis Identifies Genes Involved in Rifampin Tolerance

Microorganisms, 2023
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), poses a global health challenge and is responsible for over a million deaths each year.
William M. Matern, Harley T. Harris, Carina Danchik, Marissa McDonald, Gopi Patel, Aashish Srivastava, Thomas R. Ioerger, Joel S. Bader, Petros C. Karakousis   +8 more
doaj   +1 more source

A Long-Acting Thermoresponsive Injectable Formulation of Tin Protoporphyrin Sustains Antitubercular Efficacy in a Murine Infection Model

ACS Pharmacology & Translational Science, 2020
Tuberculosis is the leading cause of death from a single infectious agent, ranking above the human immunodeficiency virus (HIV). Effective treatment using antibiotics is achievable, but poor patient compliance constitutes a major challenge impeding ...
Oluwatoyin A. Adeleke, Logan Fisher, Ian N. Moore, G. Nardone, A. Sher   +4 more
semanticscholar   +1 more source

The Synergistic Effects of the Glutathione Precursor, NAC and First-Line Antibiotics in the Granulomatous Response Against Mycobacterium tuberculosis

Frontiers in Immunology, 2018
Mycobacterium tuberculosis (M. tb), the causative bacterial agent responsible for tuberculosis (TB) continues to afflict millions of people worldwide. Although the human immune system plays a critical role in containing M.
Garrett Teskey, Ruoqiong Cao, Ruoqiong Cao, Hicret Islamoglu, Albert Medina, Chaya Prasad, Ramaa Prasad, Airani Sathananthan, Marcel Fraix, Selvakumar Subbian, Li Zhong, Li Zhong, Li Zhong, Vishwanath Venketaraman, Vishwanath Venketaraman   +14 more
doaj   +1 more source

Review for QSAR studies and drug design of selected heterocyclic nucleus of antitubercular drugs

World Journal of Biology Pharmacy and Health Sciences
This review article explores the pressing issue of drug-resistant strains of Mycobacterium tuberculosis, which have emerged due to the widespread and uncontrolled use of antibiotics in clinical settings over several decades. In response to this challenge,
R. R. Jiyo, V. Rajan, M. H. Sankerji
semanticscholar   +1 more source

Cell-penetrating peptide conjugates of indole-3-acetic acid-based DNA primase/Gyrase inhibitors as potent antitubercular agents against planktonic and biofilm culture of Mycobacterium smegmatis

bioRxiv, 2020
Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium that caused 1.5 million fatalities globally in 2018. New strains of Mtb resistant to all known classes of antibiotics pose a global healthcare problem.
R. P. Dewangan, Meenakshi Singh, Stefan Ilic, Benjamin Tam, B. Akabayov   +4 more
semanticscholar   +1 more source

Nucleophilic substitution of a phthalimidyl group with morpholine in an N1‐methyl‐1,2,3‐triazole: crystallographic evidence for migration of the methylene bridge

Acta Crystallographica Section C, EarlyView.
X‐ray crystallography revealed that the reaction of 2‐{[4‐(4‐bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide with morpholine led to substitution of the phthalimide group, including migration of the substituent from N1 to N2 on the 1,2,3‐triazole ring.2‐{[4‐(4‐Bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide, C17H11BrN4O, was synthesized by ...
Paul R. Palme, Richard Goddard, Markus Leutzsch, Adrian Richter, Peter Imming, Rüdiger W. Seidel   +5 more
wiley   +1 more source

Synthesis, Characterization, Theoretical Treatment and Antitubercular activity Evaluation of (E)-N’- (2,5-dimethoxylbenzylidene)nicotinohydrazide and some of its Transition Metal Complexes against Mycobacterium tuberculosis, H37Rv [PDF]

, 2016
(E)-N’-(2,5-dimethoxylbenzylidene)nicotinohydrazide) (HL) was synthesized by condensing nicotinic acid hydrazide and 2,5-dimethoxylbenzaldehyde with ONO coordination pattern.
Adekoya, J. A.
core   +1 more source

Total Synthesis and Structural Reassignment of the Antitubercular Natural Product Evybactin

Chemistry
The escalating threat posed by antibiotic resistance is a global concern and underscores the need for new antibiotics. In this context, the recent discovery of evybactin, a nonribosomal depsipeptide antibiotic that selectively and potently inhibits the ...
Vladyslav Lysenko, Sangkeun Son, Monique E. Theriault, Cornelis J Slingerland, Glenn Hauk, Laurence Cleenewerk, Alexander Speer, James M. Berger, Kim Lewis, N. Martin   +9 more
semanticscholar   +1 more source

Ionophoric effects of the antitubercular drug bedaquiline

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Antibiotics generally target one of five essential cellular functions in bacteria, but many of these targets are now compromised through rapidly spreading antibiotic resistance.
Kiel Hards, D. G. McMillan, L. Schurig-Briccio, R. Gennis, H. Lill, D. Bald, G. Cook   +6 more
semanticscholar   +1 more source

Synthesis, Biological Evaluation, and Theoretical Study of Indenoquinolinylphosphine Oxide Derivatives as Topoisomerase 1 Inhibitors and Antiproliferative Agents

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
The topoisomerase I inhibition and antiproliferative activities of phosphorated indenoquinoline derivatives were investigated. The target hybrid quinoline and tetrahydroquinoline compounds were synthesized via a two‐step Povarov‐type cycloaddition.
Alba Rodriguez, Elena Formoso, Birgitta R. Knudsen, Cinzia Tesauro, Maria Fuertes, Concepcion Alonso   +5 more
wiley   +1 more source