Results 61 to 70 of about 842,782 (192)

Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment [PDF]

, 2013
BACKGROUND: New alternatives for the treatment of Tuberculosis (TB) are urgently needed and medicinal plants represent a potential option. Chamaedora tepejilote and Lantana hispida are medicinal plants from Mexico and their hexanic extracts have shown ...
Adelina Jiménez-Arellanes, Brenda Marquina, Dulce Mata-Espinosa, Javier Torres, Jorge Cornejo-Garrido, Julieta Luna-Herrera, Mariana Meckes-Fischer, María Eugenia Castro-Mussot, Rogelio Hernández-Pando, Sonia López-García   +9 more
core   +1 more source

Genetic stability of Mycobacterium smegmatis under the stress of first-line antitubercular agents

bioRxiv
The sustained success of Mycobacterium tuberculosis as a pathogen arises from its ability to persist within macrophages for extended periods and its limited responsiveness to antibiotics. Furthermore, the high incidence of resistance to the few available
Dániel Molnár, É. Surányi, Tamás Trombitás, Dóra Füzesi, Rita Hírmondó, Judit Tóth   +5 more
semanticscholar   +1 more source

In Vitro Susceptibility of Mycobacterium abscessus and Mycobacterium fortuitum Isolates to 30 Antibiotics

BioMed Research International, 2018
Objective Nontuberculous mycobacteria (NTM) cause various diseases in humans and animals. Recently, the prevalence of NTM-related disease has been on the rise, becoming an emerging public health problem.
Yaojie Shen, Xuyang Wang, Jialin Jin, Jing Wu, Xuelian Zhang, Jiazhen Chen, Wenhong Zhang   +6 more
semanticscholar   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Assessment of Mycobacterium Tuberculosis Sensitive Antibiotics from the Isolation of LJ Media

Indian Journal of Public Health Research & Development, 2020
Pulmonary tuberculosis (PTB) is the major public health air borne disease of India. Socio-economic burden of this disease is also high due to its morbidity and mortality. Patients become resistant to antitubercular antibiotics due to not selecting proper
Zafar Nowshad Wani, Pushpa Yadav, G. Jaiswal, M. Malakar   +3 more
semanticscholar   +1 more source

The Synergistic Effects of the Glutathione Precursor, NAC and First-Line Antibiotics in the Granulomatous Response Against Mycobacterium tuberculosis

Frontiers in Immunology, 2018
Mycobacterium tuberculosis (M. tb), the causative bacterial agent responsible for tuberculosis (TB) continues to afflict millions of people worldwide. Although the human immune system plays a critical role in containing M.
Garrett Teskey, Ruoqiong Cao, Ruoqiong Cao, Hicret Islamoglu, Albert Medina, Chaya Prasad, Ramaa Prasad, Airani Sathananthan, Marcel Fraix, Selvakumar Subbian, Li Zhong, Li Zhong, Li Zhong, Vishwanath Venketaraman, Vishwanath Venketaraman   +14 more
doaj   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Luteolin as a potential host-directed immunotherapy adjunct to isoniazid treatment of tuberculosis.

PLoS Pathogens, 2021
Tuberculosis (TB) remains a major health problem throughout the world with one third of the population latently infected and ~1.74 million deaths annually.
Dhiraj Kumar Singh, Sultan Tousif, Ashima Bhaskar, Annu Devi, Kriti Negi, Barnani Moitra, Anand Ranganathan, Ved Prakash Dwivedi, Gobardhan Das   +8 more
doaj   +1 more source

Tuberculosis of Frontal Bone—A Rare Entity: Case Report and Review of Literature

Indian Journal of Medical and Paediatric Oncology
Tuberculosis of the frontal bone is a rare entity, most commonly occurring in childhood. In situations of painless scalp swelling coupled with or without a discharging sinus that has not responded to antibiotics, a strong index of suspicion must be ...
Jeba Nazneen, Vasundhara Patil, Ujjwal Agarwal, Aashna Karbhari, Gauri Bornak, Pranjal Rai, Abhishek Mahajan   +6 more
doaj   +1 more source

Synthesis, Characterization, and Bioactivity of Quinoxaline Thiazolotriazoles

Journal of Heterocyclic Chemistry, EarlyView.
Quinoxaline thiazolotriazole target molecules with antibacterial, antitubercular and antidiabetic activity. ABSTRACT A total of 10 quinoxaline thiazolo[2,3‐c][1,2,4]triazole hybrid molecules were synthesized in a four‐step synthetic protocol. Six of these compounds are reported here for the first time.
Silungile Mhlongo, Sibusiso Senzani, Shahidul Islam, Kolawole Olofinsan, Moganavelli Singh, Nirasha Nundkumar, Sithabile Mokoena, Rajshekhar Karpoormath, Neil A. Koorbanally   +8 more
wiley   +1 more source