Results 71 to 80 of about 842,782 (192)

Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis [PDF]

, 2013
SummaryBiotin biosynthesis is essential for survival and persistence of Mycobacterium tuberculosis (Mtb) in vivo. The aminotransferase BioA, which catalyzes the antepenultimate step in the biotin pathway, has been established as a promising target due to
Park, Sae Woong, Casalena, Dominick E., Wilson, Daniel J., Dai, Ran, Nag, Partha P., Liu, Feng, Boyce, Jim P., Bittker, Joshua A., Schreiber, Stuart L., Finzel, Barry C., Schnappinger, Dirk, Aldrich, Courtney C.   +11 more
core   +1 more source

The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles

Pharmaceuticals
Tuberculosis (TB) is notorious as the leading cause of death worldwide due to a single infectious entity and its causative agent, Mycobacterium tuberculosis (Mtb), has been able to evolve resistance to all existing drugs in the treatment arsenal ...
Helena I. Boshoff, Neha Malhotra, Clifton E. Barry, Sangmi Oh   +3 more
doaj   +1 more source

In‐Silico Exploration of the StreptomeDB Database for Potential Irreversible DprE1 Inhibitors toward Antitubercular Treatment

ChemistryOpen, EarlyView.
StreptomeDB‐derived nitro compounds are screened against Mycobacterium tuberculosis decaprenylphosphoryl‐D‐riboseoxidase (DprE1) . Covalent docking, molecular dynamics simulations, and molecularmechanics/generalized Born surface area analyses identify hydroxythaxtomin and lajollamycin B as potent DprE1 inhibitors, surpassing the reference PBTZ169 in ...
Doaa G. M. Mahmoud, Gamal A. H. Mekhemer, Mohamed‐Elamir F. Hegazy, Jabir H. Al‐Fahemi, Mahmoud A. A. Ibrahim   +4 more
wiley   +1 more source

Cutaneous tuberculosis (scrofuloderma) in a five year-old boy: Case report [PDF]

, 2009
Cutaneous tuberculosis (CTB) is a rare form of extrapulmonary TB in our region. The incidence of CTB seems to be increasing in some countries. CTB continues to be one of the most elusive and difficult diagnoses to make for dermatologists practicing in ...
Dehghan, M., Kazeminezhad, V., Najafi, L.   +2 more
core  

Inhalable antitubercular therapy mediated by locust bean gum microparticles [PDF]

, 2016
Tuberculosis remains a major global health problem and alternative therapeutic approaches are needed. Considering the high prevalence of lung tuberculosis (80% of cases), the pulmonary delivery of antitubercular drugs in a carrier system capable of ...
Alves, Ana, Cavaco, Joana, Costa, Ana M. Rosa da, Grenha, Ana, Guerreiro, Filipa, Lourenço, J. P.   +5 more
core   +2 more sources

Advancing Tuberculosis Chemotherapy: Targeted Nanomedicines for the Mycobacterium TB Granuloma

Small, EarlyView.
This graphical abstract illustrates nanosystems used for targeted drug delivery into tuberculosis granulomas. It shows how targeting is influenced by size, pH, redox sensitivity, and surface charge. Various nanoparticles are incorporated with drugs to enhance penetration, stability, and release.
Shreya Ranjith Singh, Maya Mellisa Makatini, Thashree Marimuthu, Yahya Essop Choonara   +3 more
wiley   +1 more source

Antimicrobial Resistance in Zambia: A Systematic Review

International Journal of Infectious Diseases, 2022
Purpose: Antimicrobial resistance (AMR) is widely acknowledged as a global health problem, yet its extent is not well evaluated, especially in low-middle income countries (LMICs). The SARS-COV-2 pandemic demonstrates the link between humans, animals, and
A. Nowbuth, A. Asombang, N. Tazikeng, O. Makinde, L. Sheets   +4 more
doaj   +1 more source

Extrapolation of lung pharmacokinetics of bedaquiline across species using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, Volume 91, Issue 11, Page 3167-3178, November 2025.
Aims Bedaquiline (BDQ) is a first‐in‐class diarylquinoline (DARQ) and a potent anti‐tuberculosis drug, vital in combating multi‐drug resistant tuberculosis (TB). Understanding its lung pharmacokinetics (PK) across species is crucial for effective clinical translation.
Evangelos Karakitsios, Oscar Della Pasqua, Aristides Dokoumetzidis   +2 more
wiley   +1 more source

Exploration of the chemistry and biological properties of pyrimidine as a privileged pharmacophore in therapeutics [PDF]

, 2015
The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin B1.
Ajani, Olayinka O.
core   +4 more sources

(E)-N'-(2, 4-dihydroxybenzylidene)nicotinohydrazide and its Metal Complexes: Synthesis, Characterisation and Antitubercular Activity [PDF]

, 2016
Nicotinic acid hydrazide and 2,4-dihydoxylbenzaldehyde were condensed at 20 °C to form an acylhydrazone (H3L1) with ONO coordination pattern. The structure of the acylhydrazone was elucidated by using CHN analyzer, ESI mass spectrometry, IR, 1H NMR, 13C ...
Adekoya, J. A.
core