Results 71 to 80 of about 951,869 (260)

Tuberculosis of Frontal Bone—A Rare Entity: Case Report and Review of Literature

Indian Journal of Medical and Paediatric Oncology
Tuberculosis of the frontal bone is a rare entity, most commonly occurring in childhood. In situations of painless scalp swelling coupled with or without a discharging sinus that has not responded to antibiotics, a strong index of suspicion must be ...
Jeba Nazneen, Vasundhara Patil, Ujjwal Agarwal, Aashna Karbhari, Gauri Bornak, Pranjal Rai, Abhishek Mahajan   +6 more
doaj   +1 more source

Luteolin as a potential host-directed immunotherapy adjunct to isoniazid treatment of tuberculosis.

PLoS Pathogens, 2021
Tuberculosis (TB) remains a major health problem throughout the world with one third of the population latently infected and ~1.74 million deaths annually.
Dhiraj Kumar Singh, Sultan Tousif, Ashima Bhaskar, Annu Devi, Kriti Negi, Barnani Moitra, Anand Ranganathan, Ved Prakash Dwivedi, Gobardhan Das   +8 more
doaj   +1 more source

Exploring novel antitubercular agents: Innovative design of 2,3-diaryl-quinoxalines targeting DprE1 for effective tuberculosis treatment

Open Chemistry
The rising instances of drug resistance in Mycobacterium tuberculosis strains pose a significant global health challenge. Conventional tuberculosis (TB) treatments, which typically involve multiple antibiotics, face hurdles like drug resistance, reduced ...
Kirti Sharma, Atul Sharma, Mohit Sanduja, Vikas Jogpal, A. Mishra, G. Kumar, Tarun Virmani, Omar M. Noman, Abdulsalam Alhalmi   +8 more
semanticscholar   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles

Pharmaceuticals
Tuberculosis (TB) is notorious as the leading cause of death worldwide due to a single infectious entity and its causative agent, Mycobacterium tuberculosis (Mtb), has been able to evolve resistance to all existing drugs in the treatment arsenal ...
Helena I. Boshoff, Neha Malhotra, Clifton E. Barry, Sangmi Oh   +3 more
doaj   +1 more source

GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876

Microbiology Spectrum, 2023
ABSTRACT The Mycobacterium tuberculosis ( Mtb ) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target and discovered the novel diaminopyrimidine
Priya Ragunathan, Pearly Shuyi Ng, Samsher Singh, Wee Han Poh, Dennis Litty, Nitin Pal Kalia, Simon Larsson, Amaravadhi Harikishore, Scott A. Rice, Philip W. Ingham, Volker Müller, Garrett Moraski, Marvin J. Miller, Thomas Dick, Kevin Pethe, Gerhard Grüber   +15 more
openaire   +4 more sources

Cutaneous tuberculosis (scrofuloderma) in a five year-old boy: Case report [PDF]

, 2009
Cutaneous tuberculosis (CTB) is a rare form of extrapulmonary TB in our region. The incidence of CTB seems to be increasing in some countries. CTB continues to be one of the most elusive and difficult diagnoses to make for dermatologists practicing in ...
Dehghan, M., Kazeminezhad, V., Najafi, L.   +2 more
core  

Conservative management of tubercular intestinal obstruction with antitubercular drugs and steroid

Journal of Medical Science And clinical Research
Objective: Tubercular intestinal obstruction is a challenging condition often necessitating surgical intervention. This case study aims to evaluate the effectiveness of conservative management, including antitubercular therapy, short-course steroids, and
Dr Jayesh Kalbhande
semanticscholar   +1 more source

Genetic stability of Mycobacterium smegmatis under the stress of first-line antitubercular agents

bioRxiv
The sustained success of Mycobacterium tuberculosis as a pathogen arises from its ability to persist within macrophages for extended periods and its limited responsiveness to antibiotics. Furthermore, the high incidence of resistance to the few available
Dániel Molnár, É. Surányi, Tamás Trombitás, Dóra Füzesi, Rita Hírmondó, Judit Tóth   +5 more
semanticscholar   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source