Results 201 to 210 of about 38,829 (239)
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Australian and New Zealand Journal of Medicine, 1991
This review has focused on some recent developments which have begun to define the immunologic specificity of aPL antibodies. These studies have revealed that these immunoglobulins are more complex than has been realised to date and, more importantly, they offer new approaches to investigate how the prothrombotic diathesis associated with aPL ...
H P, McNeil, S A, Krilis
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This review has focused on some recent developments which have begun to define the immunologic specificity of aPL antibodies. These studies have revealed that these immunoglobulins are more complex than has been realised to date and, more importantly, they offer new approaches to investigate how the prothrombotic diathesis associated with aPL ...
H P, McNeil, S A, Krilis
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The antiphospholipid antibodies
Haematologia, 2001Antiphospholipid antibodies (APLAs) are a group of autoantibodies directed against certain phospholipids, or their protein cofactors. Assay of APLAs is important because their interaction with anionic phospholipid-protein cofactors can generate a syndrome of hypercoagulability associated with a wide variety of thromboembolic events.
Cristina, Tanaseanu +3 more
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Annals of Neurology, 1989
AbstractLupus anticoagulants and anticardiolipin antibodies, known collectively as antiphospholipid antibodies, are becoming established as markers for increased risk of thrombosis, including ischemic cerebrovascular disease. In this brief review, we highlight evidence for an against a pathogenetic role of these antibodies in ischemic brain disease and
S R, Levine, K M, Welch
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AbstractLupus anticoagulants and anticardiolipin antibodies, known collectively as antiphospholipid antibodies, are becoming established as markers for increased risk of thrombosis, including ischemic cerebrovascular disease. In this brief review, we highlight evidence for an against a pathogenetic role of these antibodies in ischemic brain disease and
S R, Levine, K M, Welch
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Antiphospholipid antibodies and the antiphospholipid syndrome
Springer Seminars in Immunopathology, 1994The study of aPL antibodies and the APS has appealed to large numbers of investigators over the last decade. This accounts, in part, for the great degree of apparently contradictory data being published. What seems certain is that these antibodies are associated with thrombosis and recurrent pregnancy loss, and animal data suggest a direct role in ...
E N, Harris, S S, Pierangeli
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Antiphospholipid antibodies and antiphospholipid syndrome
Current Opinion in Rheumatology, 1995More than a decade has gone by since the detailed clinical description of antiphospholipid syndrome (APS). Thrombosis, the main complication of the syndrome, can affect vessels of all sizes; the consistent histopathologic lesion is a bland thrombus without inflammation.
M A, Khamashta, G R, Hughes
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Antiphospholipid Antibodies and Reproduction: The Antiphospholipid Antibody Syndrome
American Journal of Reproductive Immunology, 1999In women who have a diagnosis of APS (both clinical and laboratory criteria) the chance for successful pregnancy is reduced. In these cases, treatment appears to be a clear option, particularly in the case of prior thromboembolic events. The current preference of treatment for women with RPL and aPL antibodies is subcutaneous heparin and aspirin.
W H, Kutteh, N S, Rote, R, Silver
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ANTIPHOSPHOLIPID ANTIBODIES AND THE ENDOTHELIUM
Rheumatic Disease Clinics of North America, 2001The interaction between aPL (particularly anti-beta 2GPI antibodies) and endothelium does represent a potential pathogenetic mechanism for the thrombotic manifestations of the syndrome. The autoantibody-mediated EC activation probably plays a role in sustaining the appearance of a proadhesive, proinflammatory, and procoagulant phenotype.
P. L. Meroni +4 more
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Antiphospholipid antibodies and the antiphospholipid antibody syndrome
Journal of the American Academy of Dermatology, 1997The antiphospholipid antibody syndrome is a multiple-system disorder characterized by persistently elevated antiphospholipid antibodies and/or arterial or venous thrombosis, thrombocytopenia, or recurrent spontaneous abortion. Anticardiolipin antibodies and the lupus anticoagulant are different classes of antiphospholipid antibodies associated with ...
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Antiphospholipid antibody and antiphospholipid antibody syndrome
Current Opinion in Rheumatology, 1991New details have been added to the description of the antiphospholipid antibody syndrome. These include quantitation of risk of stroke; delineation of an associated acute occlusive vasculopathy syndrome, including its pathology; increased awareness of the association of adrenal insufficiency with antiphospholipid antibody; new demonstration of ...
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Antiphospholipid syndrome, antiphospholipid antibodies, and atherosclerosis
Current Atherosclerosis Reports, 2001The antiphospholipid syndrome is characterized by arterial and venous thrombosis, as well as pregnancy morbidity, in the presence of elevated levels of antiphospholipid antibodies. These autoantibodies have procoagulant activity, as they affect platelets, humoral coagulation factors, and endothelial cells.
Y, Sherer, Y, Shoenfeld
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