Results 201 to 210 of about 85,259 (288)

Cytokine biomarkers and their relationship to symptoms and quality of life in people with HIV‐associated Kaposi sarcoma

HIV Medicine, EarlyView.
Abstract Introduction Quality of life (QOL) is an essential component of care in people with HIV‐associated Kaposi sarcoma (HIV‐KS). Kaposi sarcoma herpes virus (KSHV) promotes cytokine expression and a dysfunctional inflammatory environment, contributing to KS pathogenesis and progression.
Fahmida Shaik, Thomas Smith Uldrick, Mikateko Mazinu, Nomonde Gwebushe, Anisa Mosam   +4 more
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, and Immunogenicity of CM313 in Healthy Participants: An Open-Label/Double-Blind, Randomized, Placebo-Controlled Phase 1 Trial. [PDF]

Clin Transl Sci
Yu S, Wu J, Zhao J, He J, Yan H, Zhang X, Yang Y, Song H, Hou Q, Guo B, Qiu Y, Chen B, Xue Y, Zhang J.   +13 more
europepmc   +1 more source

The Influence of Psychological Stress and Stress‐Related Disorders in the Treatment Outcome of Periodontitis: A Systematic Review and Meta‐Analysis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background and Objective In humans 16 years and above with periodontitis (Population), how do psychological stress and stress‐related disorders (PSRD; Exposure) compared to those without PSRD (Comparison) affect clinical attachment level (CAL) upon periodontitis treatment (Outcome), as observed in experimental studies or descriptive pre–post ...
Erik Klepsland Mauland, Sudan Prasad Neupane   +1 more
wiley   +1 more source

An Effective Prophylactic and Therapeutic Protection Against Botulinum Type A Intoxication in Mice and Rabbits Using a Humanized Monoclonal Antibody. [PDF]

Toxins (Basel)
Yu CH, Song YJ, Song DH, Joe HE, Kim CH, Yun H, Kim NY, Sim E, Jeong ST, Hur GH.   +9 more
europepmc   +1 more source

Efficacy and safety of biologics for hidradenitis suppurativa: A network meta‐analysis of phase III trials

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Data from 2731 patients with hidradenitis suppurativa (HS) treated with biologics for 12–16 weeks in phase III randomized controlled trials (RCT) were included in a network meta‐analysis (NMA). Adalimumab showed the highest efficacy in achieving a clinical HS response 50 (HiSCR50) and the lowest incidence of adverse events (AE).
Laura Calabrese, Alessandra Cartocci, Pietro Rubegni, Lars E. French, Benjamin Kendziora   +4 more
wiley   +1 more source

Reduction of extracellular vimentin in blood provides protection against SARS-CoV-2 infection. [PDF]

Virulence
Kim HM, Wang M, Zhai C, Kim S, Park J, Hong ST.   +5 more
europepmc   +1 more source

Developing downstream processes for the purification of recombinant proteins and small molecules from Nicotiana benthamiana biomass

Plant Biotechnology Journal, EarlyView.
Summary Nicotiana benthamiana (Australian tobacco) has become a major host for plant‐based recombinant protein production, especially using transient expression. Once a candidate protein has been designed and produced in a suitable variety (e.g. facilitated humanized glycosylation) under reproducible conditions (e.g.
J. F. Buyel
wiley   +1 more source

Successful targeting of multidrug-resistant tumors with bispecific antibodies. [PDF]

MAbs
Briante R, Zhai Q, Mohanty S, Zhang P, O'Connor A, Misker H, Wang W, Tan C, Abuhay M, Morgan J, Theolis R, Ponath P, Arathoon R.   +12 more
europepmc   +1 more source

Monoclonal antibodies to human IgM

Medical Journal of Indonesia, 1999
Agustin Indrawati, Fera Ibrabim, Mardiastuti Mardiastuti, Agus Sjahrurachman, Betty Ernawati   +4 more
openaire   +3 more sources

CRISPR/Cas9‐Mediated Knockouts of the ALG3 and GNTI in N. benthamiana and Their Application to Pharmaceutical Production

Plant Biotechnology Journal, EarlyView.
ABSTRACT N‐Glycosylation critically influences the efficacy, safety and pharmacokinetic properties of biopharmaceuticals. Plant expression platforms offer multiple advantages for the production of N‐glycosylated proteins, but their use is impeded by the presence of plant‐specific N‐glycan epitopes, which raise concerns of possible immunogenicity to ...
Dolgormaa Bataa, Hiroyuki Kajiura, Reimi Lai Sang Sawada‐Choi, Yukino Yamashita, Takeshi Ishimizu, Ryo Misaki, Atsushi Takeda, Kazuhito Fujiyama   +7 more
wiley   +1 more source