Results 221 to 230 of about 56,276 (247)

Monoclonal antibodies against human chondrocytes

In Vitro Cellular & Developmental Biology - Animal, 1996
Cell-specific antigens are mainly found in cells or membrane surfaces rather than in the surrounding matrix. However, until now it was not possible to produce antibodies specific for cellular structures of chondrocytes. In 1989, Lance (Immunol. Lett.
Bujia, J., Sittinger, M., Sudhoff, Holger, Fisseler-Eckhoff, A., Burmester, G. R., Kastenbauer, E., Hammer, C.   +6 more
openaire   +3 more sources

Humanization of Monoclonal Antibodies

1994
Antibodies of predefined specificity have many potential uses in human therapy and diagnosis, and hybridoma technology (Koehler and Milstein 1975) has made possible the generation of virtually limitless amounts of such antibodies. Unfortunately, hybridoma proteins are more easily obtained from nonhuman, usually rodent, sources and the use of those ...
G. E. Mark, E. A. Padlan
openaire   +2 more sources

Monoclonal antibodies and therapy of human cancers

Biotechnology Advances, 2000
This survey is an overview of the applications of murine, humanized and recombinant monoclonal antibodies for in vivo diagnostic and therapeutic applications. Monoclonal antibodies (mAb) have been applied to the diagnosis and therapy of an array of human diseases.
FUNARO, Ada, HORENSTEIN A. L, SANTORO P, CINTI C, GREGORINI A, MALAVASI, Fabio   +5 more
openaire   +5 more sources

An inhibitory monoclonal antibody to human acetylcholinesterases

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1987
The monoclonal antibody AE-2 raised against acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) from human erythrocytes is shown to inhibit the enzyme activity. The reaction of the antibody with a structural epitope is investigated further. The epitope resides on monomeric, dimeric and tetrameric species of the enzyme.
Sorensen, K, Brodbeck, U, Rasmussen, A G, Norgaard-Pedersen, B   +3 more
openaire   +4 more sources

A Human Monoclonal Antibody to rh^G

Vox Sanguinis, 1986
Abstract. Hybridomas secreting a human monoclonal IgG1 antibody against a variant of the rhG antigen were produced from B lymphocytes of an Rh‐negative donor with serum antibodies to D and C antigens. The antibody reacts by indirect hemagglutination with nearly all C‐ or D‐positive cells, confirming the strong association in the expression of G with D
Susan Perkins, F. Carl Grumet, Linda Winn, Steven K. H. Foung, Judy Blunt   +4 more
openaire   +3 more sources

Humanization and Simultaneous Optimization of Monoclonal Antibody

2013
Antibody humanization is an essential technology for reducing the potential risk of immunogenicity associated with animal-derived antibodies and has been applied to a majority of the therapeutic antibodies on the market. For developing an antibody molecule as a pharmaceutical at the current biotechnology level, however, other properties also have to be
Hiroyuki Tsunoda, Tomoyuki Igawa, Kunihiro Hattori, Taichi Kuramochi   +3 more
openaire   +4 more sources

Human monoclonal macroglobulins with antibody activity

Seminars in Oncology, 2003
Assays for specific antigen-binding activity were performed on sera from 172 patients with monoclonal macroglobulinemia defined by immunofixation electrophoresis. The sera were collected between 1970 and 2002. Mean IgM level was 1,409 mg/dL with a range from 70 to 6,800.
Alan Pestronk, Marvin J. Stone, Janet L. Reynolds, Alex W. Tong, Yolonda G. McElroy, Joseph T. Newman   +5 more
openaire   +3 more sources

A Monoclonal Antibody for Immunopurification of Human Renin

Clinical Science, 1981
1. A mouse hybridoma secreting an antibody directed against human renin was obtained by fusion of spleen cells with NS 1 myeloma cells. This monoclonal antibody recognizes human and monkey renins but neither hog nor mouse renins nor the acid proteinase cathepsin D. 2. Monoclonal antibody was coupled to Sepharose 4 B.
Bernard Pau, F X Galen, C. Devaux, Pierre Corvol, Joël Ménard, Florent Soubrier, D Simon   +6 more
openaire   +3 more sources

Human Hybridomas and Monoclonal Antibodies

1985
In this review I will cover, from a cell biologist’s perspective, the biology of cell fusion and how the information derived from the field may be applicable to the production of human monoclonal antibodies. I will describe the development of the hybridoma technology, the advantages and disadvantages of making and using monoclonal antibodies, the ...
Edgar G. Engleman, Steven K. H. Foung, James W. Larrick, Andrew Raubitschek   +3 more
openaire   +4 more sources

Human Monoclonal Antibodies: Recent Achievements

Hospital Practice, 1994
The latest developments include an anti-HIV antibody that has 1,000 times the affinity of natural antibody and that neutralizes primary clinical isolates, and an anti-RSV antibody that reduces viral titers in mice by 12,000-fold within 24 hours.
C F Barbas rd, Dennis R. Burton
openaire   +3 more sources