Results 171 to 180 of about 5,065,448 (337)

Anti-VEGF Antibody Protects against Alveolar Exudate Leakage Caused by Vascular Hyperpermeability, Resulting in Mitigation of Pneumonitis Induced by Immunotherapy

, 2021
Toshiki Iwai, Masamichi Sugimoto, Hina Patel, Keigo Yorozu, Mitsue Kurasawa, Osamu Kondoh   +5 more
openalex   +2 more sources

Antibody repertoire and autoimmunity [PDF]

, 2023
Chrysanthi Skevaki, Duane R. Wesemann
openalex   +1 more source

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Nature, 2021
Tyler N. Starr, N. Czudnochowski, Zhuoming Liu, F. Zatta, Young-Jun Park, A. Addetia, D. Pinto, M. Beltramello, P. Hernandez, Allison J. Greaney, R. Marzi, W. Glass, Ivy Zhang, A. Dingens, John E. Bowen, M. A. Tortorici, A. Walls, Jason A. Wojcechowskyj, A. De Marco, Laura E. Rosen, Jiayi Zhou, Martin Montiel-Ruiz, Hannah Kaiser, J. Dillen, H. Tucker, J. Bassi, C. Silacci-Fregni, M. P. Housley, J. di Iulio, Gloria Lombardo, Maria L. Agostini, Nicole Sprugasci, K. Culap, S. Jaconi, M. Meury, Exequiel Dellota Jr, R. Abdelnabi, S. Foo, E. Cameroni, S. Stumpf, T. Croll, J. Nix, C. Havenar-Daughton, L. Piccoli, F. Benigni, J. Neyts, A. Telenti, Florian A. Lempp, M. Pizzuto, J. Chodera, C. Hebner, H. Virgin, S. Whelan, D. Veesler, D. Corti, J. Bloom, G. Snell   +56 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Grp94-specific monoclonal antibody to counteract BRAF inhibitor resistance in BRAFV600E melanoma [PDF]

, 2015
Francesco Sabbatino, Elvira Favoino, Yun Wang, X Wang, Vincenzo Villani, Li Cai, Li Yang, Soldano Ferrone, C.R. Ferrone   +8 more
openalex   +1 more source

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics [PDF]

, 2021
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba T. Macias, Yasmina Abdiche, William Harriman, Philip A. Leighton   +7 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Evaluation of Influenza Virus A/H3N2 and B Vaccines on the Basis of Cross-Reactivity of Postvaccination Human Serum Antibodies against Influenza Viruses A/H3N2 and B Isolated in MDCK Cells and Embryonated Hen Eggs [PDF]

, 2012
Noriko Kishida, Seiichiro Fujisaki, Masaru Yokoyama, Hironori Sato, Reiko Saito, Hideyuki Ikematsu, Hong Xu, Emi Takashita, Masato Tashiro, Shinichi Takao, Takuya Yano, Tomoko Suga, Chiharu Kawakami, Miwako Yamamoto, Keiko Kajiyama, Hiroyuki Saito, S Shimada, Sumi Watanabe, Satomi Aoki, Katsuya Taira, Miyako Kon, Jih‐Hui Lin, Takato Odagiri   +22 more
openalex   +1 more source