Results 291 to 300 of about 3,695,210 (335)
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Current Opinion in Chemical Biology, 1998
Following the end of the first decade in catalytic antibody research, recent efforts are reflecting a more introspective view of the field. Notably, X-ray crystal structure analyses of antibody catalysts are permitting an increased understanding of the evolution and modus operandi of these remarkable biocatalysts. Additionally, the breadth and scope of
P, Wentworth, K D, Janda
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Following the end of the first decade in catalytic antibody research, recent efforts are reflecting a more introspective view of the field. Notably, X-ray crystal structure analyses of antibody catalysts are permitting an increased understanding of the evolution and modus operandi of these remarkable biocatalysts. Additionally, the breadth and scope of
P, Wentworth, K D, Janda
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Antiacetylcholinesterase antibodies: Enzyme antibodies interaction
Pharmacological Research Communications, 1981Summary Erythrocyte acetylcholinesterase activity of rabbits was significantly increased over control levels by immunization with acetylcholinesterase from the electric organ of the electric eel. The increase of enzyme activity and that of anti-acetylcholinesterase antibodies had the same time course, reaching a maximum level on the 35th day.
D, Pedretti +3 more
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Phage antibodies: will new ‘coliclonal’ antibodies replace monoclonal antibodies?
Trends in Biotechnology, 1992Antibodies can now be rapidly isolated from large and diverse recombinant libraries by displaying functional antibody fragments on the surface of bacteriophage particles and directly selecting with antigen. This method has been used to isolate antibodies, including human antibodies, with and without immunization, and to improve the affinity and ...
D J, Chiswell, J, McCafferty
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International Reviews of Immunology, 1993
One of the major advantages of genetic engineering is the ability to produce novel, hybrid antibodies. Hybrid antibodies can be assembled using fragments from different antibodies with the objective of assembling novel combinations of antibody-related effector functions.
S U, Shin, A, Wright, S L, Morrison
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One of the major advantages of genetic engineering is the ability to produce novel, hybrid antibodies. Hybrid antibodies can be assembled using fragments from different antibodies with the objective of assembling novel combinations of antibody-related effector functions.
S U, Shin, A, Wright, S L, Morrison
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Journal of Infectious Diseases, 1981
Serologic reagents have played an important role in the diagnosis, treatment, and epidemiology of infectious diseases. A new technology has been developed for generating homogeneous antibodies that can be produced in large amounts and are available indefinitely. This technique promises to increase the reliability and sensitivity of immunoassays and may
M D, Scharff, S, Roberts, P, Thammana
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Serologic reagents have played an important role in the diagnosis, treatment, and epidemiology of infectious diseases. A new technology has been developed for generating homogeneous antibodies that can be produced in large amounts and are available indefinitely. This technique promises to increase the reliability and sensitivity of immunoassays and may
M D, Scharff, S, Roberts, P, Thammana
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Science, 1986
Monoclonal antibodies elicited to haptens that are analogs of the transition state for hydrolysis of carboxylic esters behaved as enzymic catalysts with the appropriate substrates. These substrates are distinguished by the structural congruence of both hydrolysis products with haptenic fragments.
A, Tramontano, K D, Janda, R A, Lerner
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Monoclonal antibodies elicited to haptens that are analogs of the transition state for hydrolysis of carboxylic esters behaved as enzymic catalysts with the appropriate substrates. These substrates are distinguished by the structural congruence of both hydrolysis products with haptenic fragments.
A, Tramontano, K D, Janda, R A, Lerner
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