Results 201 to 210 of about 183,067 (255)
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Antibody-dependent cellular cytotoxicity in asthmatics
Journal of Allergy and Clinical Immunology, 1977Using a 51Cr-labeled, antibody-coated chicken red blood cell assay system, mononuclear cell and granulocyte preparations from infectious asthmatics, noinfectious asthmatics, and normal controls were tested for antibody-dependent cellular cytotoxicity (ADCC) capacity.
D K, Flaherty +5 more
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A mathematical model of antibody-dependent cellular cytotoxicity (ADCC) [PDF]
Journal of Theoretical Biology, 2018 Immunotherapies exploit the immune system to target and kill cancer cells, while sparing healthy tissue. Antibody therapies, an important class of immunotherapies, involve the binding to specific antigens on the surface of the tumour cells of antibodies that activate natural killer (NK) cells to kill the tumour cells.
David Gavaghan, Helen Byrne
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Antibody-dependent cellular cytotoxicity and influenza virus
Current Opinion in Virology, 2017Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can ...
Vanderven, Hillary A. +3 more
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The role of apoptosis in antibody-dependent cellular cytotoxicity
Cancer Immunology Immunotherapy, 1993Apoptosis in three lymphoma cell lines has been studied following cytotoxicity induced in vitro by normal human blood lymphocytes utilizing either natural killer (NK) or antibody-dependent cellular cytotoxic (ADCC) mechanisms. Guinea-pig L2C leukaemic lymphocytes, but not the human cell lines Daudi and Jurkat, revealed a degree of time- and temperature-
S J, Curnow +2 more
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Antibody‐dependent cellular cytotoxicity in HIV infections
The FASEB Journal, 1996ADCC is an important immune effector mechanism against tumor and virus‐infected cells that can be destroyed by the combined action of specific antibodies of IgG isotype against cell surface‐associated antigens and effector cells, predominantly of the NK phenotype. ADCC has been shown to function in vivo in several systems.
A, Ahmad, J, Menezes
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Polymorphonuclear Leukocytes in Antibody-Dependent Cellular Cytotoxicity
The Journal of Immunology, 1975Abstract Human polymorphonuclear leukocytes (PMN) lyse antibody-coated target cells in an immunologically specific fashion—antibody-dependent cellular cytotoxicity (ADCC). PMN-mediated cytolysis is independent of complement, de novo protein synthesis, and DNA replication.
R P, Gale, J, Zighelboim
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Assessment of Antibody-Dependent Cellular Cytotoxicity by Flow Cytometry
Cold Spring Harbor Protocols, 2018A useful feature of therapeutic antibodies is the ability to kill the cells to which they bind. Antibodies are capable of mediating cell killing in a variety of ways. Apoptosis, complement-mediated mechanisms, and antibody-dependent cellular cytotoxicity (ADCC) are all effects that can be assayed to characterize lead antibody candidates.
Thomas D, Duensing, Susan R, Watson
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Decreased Antibody-Dependent Cellular Cytotoxicity in Preleukemic Syndromes
Acta Haematologica, 2009In a previous report we showed decreased antibody-dependent cellular cytotoxicity (ADCC) activity of both leukemic and non-leukemic cells in human acute leukemia. In our present study, ADCC against tumor target cells was evaluated in 13 patients with preleukemic syndromes.
A, Janowska-Wieczorek +2 more
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Antibody-dependent cellular cytotoxicity in bullous diseases
Journal of the American Academy of Dermatology, 1982Antibody-dependent cellular cytotoxicity (ADCC) was studied in six patients with pemphigus vulgaris, six patients with bullous pemphigoid, and thirteen controls. All patients had extensive, severe disease. The target cell used was a human lymphoblastoid cell line (LA 237) coated with either heterologous (rabbit R3) or homologous (anti-HLA-A5) antiserum.
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Monocyte antibody-dependent cellular cytotoxicity in cancer patients
Cancer Immunology, Immunotherapy, 1984Antibody-dependent cellular cytotoxicity (ADCC) mediated by peripheral blood monocytes was determined in 120 patients who had gastrointestinal tract (GIT), lung and breast cancer, melanoma, or Hodgkin's and non-Hodgkin's lymphoma. Results were expressed in terms of maximum cytotoxicity and cytotoxicity at E:T = 1:10 and were compared with the results ...
N J, De Young, P G, Gill
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