Results 211 to 220 of about 174,708 (252)
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Assessment of Antibody-Dependent Cellular Cytotoxicity by Flow Cytometry
Cold Spring Harbor Protocols, 2018A useful feature of therapeutic antibodies is the ability to kill the cells to which they bind. Antibodies are capable of mediating cell killing in a variety of ways. Apoptosis, complement-mediated mechanisms, and antibody-dependent cellular cytotoxicity (ADCC) are all effects that can be assayed to characterize lead antibody candidates.
Thomas D, Duensing, Susan R, Watson
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Decreased Antibody-Dependent Cellular Cytotoxicity in Preleukemic Syndromes
Acta Haematologica, 2009In a previous report we showed decreased antibody-dependent cellular cytotoxicity (ADCC) activity of both leukemic and non-leukemic cells in human acute leukemia. In our present study, ADCC against tumor target cells was evaluated in 13 patients with preleukemic syndromes.
A, Janowska-Wieczorek +2 more
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Antibody-dependent cellular cytotoxicity in multiple sclerosis
Journal of the Neurological Sciences, 1980The blood serum of patients with multiple sclerosis (MS) was capable of recruiting autologous as well as normal mononuclear leucocytes in specific antibody-dependent cellular cytotoxicity (ADCC) of rat glial tumor CCL 107/C6 cells. The gliotoxic ADCC activity of MS patients was significantly higher than that of normal persons and patients with other ...
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Interspecies Variability in Antibody-Dependent Cellular Cytotoxicity (ADCC)
The Journal of Immunology, 1974Abstract Lymphoid effector cells and antisera from several species were evaluated in allogeneic or xenogeneic test systems for their ability to mediate the cytolysis of radiochromium-labeled target cells, antibody-dependent cellular cytotoxicity (ADCC).
J, Zighelboim, R P, Gale
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Antibody-Dependent Cellular Cytotoxicity in Patients on Chronic Hemodialysis
American Journal of Nephrology, 2013<b><i>Background:</i></b> Antibody (Ab)-dependent cellular cytotoxicity (ADCC) is considered to be a relevant mechanism of action of Ab-based tumor therapies. However, knowledge about ADCC capacity of dialysis patients (DP) is limited.
Till, Koch +9 more
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Development of a kinetic antibody-dependent cellular cytotoxicity assay
Journal of Immunological Methods, 2019Antibody-dependent cellular cytotoxicity (ADCC) is an important mechanism of action (MOA) of monoclonal antibody (mAb) therapeutics. Target cells opsonized with therapeutic antibody bind and activate FcγR-bearing immune effector cells, resulting in target cell lysis.
Lynn Kamen +4 more
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The effect of β-endorphin on natural cytotoxicity and antibody dependent cellular cytotoxicity
Life Sciences, 1984The ability of the central nervous system to modulate immune responsiveness has received increasing attention. A potential mechanism that would allow the central nervous system to alter the immune system is the release of neuroendocrine and neurotransmitter polypeptides into the peripheral circulation with subsequent modulation of immunocyte function ...
C J, Froelich, A D, Bankhurst
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Inhibition of Antibody-Dependent Cellular Cytotoxicity and Natural Cytotoxicity by Retinoic Acid
International Archives of Allergy and Applied Immunology, 2009The present study has shown that in vitro antibody-dependent cellular cytotoxicity and natural cytotoxicity of human blood lymphocytes are inhibited by retinoic acid (5·10-4M). The inhibition of cytotoxicity is due to a specific effect on the effector lymphocytes and not to an effect on the target cells. The reduction of killing is most pronounced with
O, Eremin, J, Ashby, J, Rhodes
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Antibody dependent cellular cytotoxicity: Cytotoxicity mediated by non T-lymphocytes
Clinical Immunology and Immunopathology, 1974Abstract The cytotoxic capacity of human lymphocytes in antibody dependent cellular cytotoxicity (ADCC) is mediated by non T-lymphocytes. Evidence is presented that purified peripheral blood T-lymphocytes as well as human thymus cells are inefective in ADCC. By contrast, lymphocytes bearing a receptor for immunoglobulin (Ig) effectively mediated this
J, Zighelboim +5 more
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In Vitro and in Vivo Investigations on Antibody-Dependent Cellular Cytotoxicity
1978It is now well established that target cell destruction can be mediated through the interaction of antibody with normal lymphoid cells as well as through the classic T-cell immunity mechanism (Cerottini and Brunner, 1974). This phenomenon, recently reviewed by Perlmann, Perlmann, and Wigzell (1972), was first described by Moller in 1965 and has ...
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