Results 21 to 30 of about 751,456 (299)

Affinity of anti-spike antibodies in SARS-CoV-2 patient plasma and its effect on COVID-19 antibody assays

open access: yesEBioMedicine, 2022
Summary: Background: Measuring anti-spike protein antibodies in human plasma or serum is commonly used to determine prior exposure to SARS-CoV-2 infection and to assess the anti-viral protection capacity.
Patrick J. Macdonald   +6 more
doaj   +1 more source

Enhancement of the neutralization ability resulting from a single amino acid change in the light chain of a chimeric antibody against SARS-CoV-2

open access: yesShanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To screen the human-mouse chimeric antibodies that neutralize the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and analyse the key amino acid site changes in their light chain.Methods·Antibody heavy chain gene-humanized mice ...
YIN Zi   +5 more
doaj   +1 more source

Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]

open access: yes, 2020
Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
core   +2 more sources

IgG Fc Affinity Ligands and Their Applications in Antibody-Involved Drug Delivery: A Brief Review

open access: yesPharmaceutics, 2023
Antibodies are not only an important class of biotherapeutic drugs, but also are targeting moieties for achieving active targeting drug delivery. Meanwhile, the rapidly increasing application of antibodies and Fc-fusion proteins has inspired the emerging
Chang Yang   +5 more
doaj   +1 more source

Effects of antibodies against tubulin on the movement of reactivated sea urchin sperm flagella [PDF]

open access: yes, 1980
Antibodies binding to sea urchin flagellar outer-doublet tubulin have been isolated from rabbit sera by tubulin-affinity chromatography employing electrophoretically purified tubulin as the immobilized substrate.
Asai, David J., Brokaw, Charles J.
core   +1 more source

Endogenous mammalian lectin localized extracellularly in lung elastic fibers. [PDF]

open access: yes, 1984
An affinity-purified antibody preparation raised against a beta-galactoside-binding lectin from bovine lung was used to localize a similar lectin in rat lung by immunofluorescence and by electron microscopy after on-grid staining visualized with ...
Barondes, SH   +2 more
core   +3 more sources

Structure Based Affinity Maturation and Characterizing of SARS-CoV Antibody CR3022 against SARS-CoV-2 by Computational and Experimental Approaches

open access: yesViruses, 2022
The COVID-19 epidemic is raging around the world. Neutralizing antibodies are powerful tools for the prevention and treatment of SARS-CoV-2 infection. Antibody CR3022, a SARS-CoV neutralizing antibody, was found to cross-react with SARS-CoV-2, but its ...
Wei Yu   +15 more
doaj   +1 more source

The use of self-assembled receptor layers in immunosensors [PDF]

open access: yes, 1994
We demonstrate that a self-assembled monolayer consisting of an alkylthiol coupled synthetic peptide adsorbed to a gold substrate results in a sensitive receptor surface for specific recognition of protein molecules. The affinity constant of this binding
Drijfhout, J.W.   +3 more
core   +3 more sources

Antibody Fragments and Their Purification by Protein L Affinity Chromatography

open access: yesAntibodies, 2015
Antibodies and related proteins comprise one of the largest and fastest-growing classes of protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however, many new entities are antibody fragments.
Gustav Rodrigo   +2 more
doaj   +1 more source

Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts

open access: yesCells, 2020
Germinal centers (GCs) are specialized compartments within the secondary lymphoid organs where B cells proliferate, differentiate, and mutate their antibody genes in response to the presence of foreign antigens.
Aurélien Pélissier   +6 more
doaj   +1 more source

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