Results 31 to 40 of about 736,142 (286)

Anticancer Drug Discovery [PDF]

open access: yesJNCI Journal of the National Cancer Institute, 1991
The National Cancer Institute's (NCI's) human tumor cell line panel for screening potential new anticancer drugs is now operational (/). Its implementation and the demonstration of its feasibility represent a technical and organizational tour de force.
openaire   +2 more sources

Identification of an Immune Gene Signature Based on Tumor Microenvironment Characteristics in Colon Adenocarcinoma

open access: yesCell Transplantation, 2021
Tumor microenvironment (TME) changes are related to the occurrence and development of colon adenocarcinoma (COAD). This study aimed to analyze the characteristics of the immune microenvironment in CC, as well as the microenvironment’s relationship with ...
Ying Chen, Jia Zhao
doaj   +1 more source

ΔIK17 Antigen: A Possible Early Marker of Cancer Development

open access: yesThe International Journal of Biological Markers, 1996
ΔIK17 is a 44 kD molecule located on the surface of T, B and NK cells in normal peripheral blood mononuclear cells (PBMC) (1). The portion of PBMC expressing ΔIK17 was determined in 52 patients with benign breast diseases, 182 patients with breast ...
S. Perez   +7 more
doaj   +1 more source

The influence of acupuncture TENS currents on the proliferation of cancer cells tested in vitro

open access: yesRehabilitacja Medyczna, 2019
Introduction: Transcutaneous Electrical Nerve Stimulation (TENS) is a very popular, non-pharmacological antianalgetic method. Nonetheless, knowledge on using this method is very limited in the treatment of patients with cancer anamnesis.
Marzena Pełczyńska   +3 more
doaj   +1 more source

Development of an interfering peptide M1-20 with potent anti-cancer effects by targeting FOXM1

open access: yesCell Death and Disease, 2023
Disrupting protein–protein interactions (PPIs) has emerged as a promising strategy for cancer drug development. Interfering peptides disrupting PPIs can be rationally designed based on the structures of natural sequences mediating these interactions ...
Huitong Bu   +8 more
doaj   +1 more source

Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]

open access: yes, 2017
An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant ...
Chmielowski, Bartosz   +15 more
core   +2 more sources

The recurrent laryngeal nerve and extralaryngeal branches in relation to the inferior thyroid artery, Berry’s ligament, tracheal groove, and Zuckerkandl tubercle: an experience of 60 thyroidectomies [PDF]

open access: yesFolia Medica
Aim: The aim of this study was to examine the anatomical variations of the inferior laryngeal nerve compared with its extralaryngeal branches, the inferior thyroid artery, Berry’s ligament, the tracheal groove, and the tubercle of Zuckerkandl, as ...
Zoi Nitsa   +3 more
doaj   +3 more sources

On-Label or Off-Label? Overcoming Regulatory and Financial Barriers to Bring Repurposed Medicines to Cancer Patients

open access: yesFrontiers in Pharmacology, 2020
Repurposing of medicines has gained a lot of interest from the research community in recent years as it could offer safe, timely, and affordable new treatment options for cancer patients with high unmet needs.
Ciska Verbaanderd   +5 more
doaj   +1 more source

Cn-AMP2 from green coconut water is an anionic anticancer peptide [PDF]

open access: yes, 2014
Globally, death due to cancers is likely to rise to over 20 million by 2030,which has created an urgent need for novel approaches to anticancer therapies such as the development of host defence peptides.
Al-Benna   +56 more
core   +1 more source

Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition

open access: yesExperimental and Molecular Medicine, 2019
Cancer: How a plant metabolite analog suppresses tumor growth A synthetic analog of a chemical found in fruit suppresses tumor growth by targeting an RNA-binding protein (hnRNPA2B1) and preventing the production of a pro-cancer regulatory factor.
Nak-Kyun Soung   +21 more
doaj   +1 more source

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